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Random walk with restart
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Identifying relatedness among diseases could help deepen understanding for the underlying pathogenic mechanisms of diseases, and facilitate drug repositioning projects. A number of methods for computing disease similarity had been developed; however, none of them were designed to utilize information of the entire protein interaction network, using instead only those interactions involving disease causing genes.
13p
vioklahoma2711
19-11-2020
15
2
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MicroRNAs (miRNAs) have been shown to play an important role in pathological initiation, progression and maintenance. Because identification in the laboratory of disease-related miRNAs is not straightforward, numerous network-based methods have been developed to predict novel miRNAs in silico.
13p
viconnecticut2711
29-10-2020
9
2
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Netpredictor is an R package for prediction of missing links in any given unipartite or bipartite network. The package provides utilities to compute missing links in a bipartite and well as unipartite networks using Random Walk with Restart and Network inference algorithm and a combination of both.
10p
viconnecticut2711
28-10-2020
12
0
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In recent years, lncRNAs (long-non-coding RNAs) have been proved to be closely related to the occurrence and development of many serious diseases that are seriously harmful to human health. However, most of the lncRNA-disease associations have not been found yet due to high costs and time complexity of traditional bio-experiments.
13p
vicolorado2711
23-10-2020
19
0
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The misregulation of microRNA (miRNA) has been shown to cause diseases. Recently, we have proposed a computational method based on a random walk framework on a miRNA-target gene network to predict disease-associated miRNAs.
13p
vicolorado2711
22-10-2020
5
0
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Finding underlying molecular mechanisms of diseases is one of the important issues in biomedical research. In which, prediction of novel disease-associated genes is mostly focused. Many methods have been proposed based on biological networks and shown effectively for the problem.
9p
vititan2711
13-08-2019
11
1
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