Rapid early response

Leukemia is one of the most common types of cancer among children around the world. Acute lymphoblastic leukemia (ALL) accounts for approximately 75% of all cases of childhood leukemia. Acute lymphoblastic leukemia (ALL) remains the most common malignancy in children.

5p vinatisu 29-08-2024 2 1   Download

The hepatocyte growth factor-regulated tyrosine kinase substrate Hrs is an early endosomal protein that is thought to play a regulatory role in the trafficking of growth factor/ receptor complexes through early endosomes. Stimulation of cells with epidermal growth factor (EGF) rapidly leads to phosphorylation of Hrs, raising the question whether the receptor tyrosine kinase phosphorylates Hrs directly. Here, we present evidence that a downstream kinase, rather than the active receptor kinase is responsible. ...

7p research12 23-04-2013 36 2   Download

Tristetraprolin is a zinc-finger-containing RNA-binding protein. Tristetra-prolin binds to AU-rich elements of target mRNAs such as proto-onco-genes, cytokines and growth factors, and then induces mRNA rapid degradation. It was observed as an immediate-early gene that was induced in response to several kinds of stimulus, such as insulin and other growth factors and stimulators of innate immunity such as lipopolysaccharides.

12p galaxyss3 21-03-2013 36 5   Download