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Rat aorta
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This thesis documents a research program in which Australian grown Danshen extracts and related bioactive compounds have been demonstrated to be effective in scavenging free radicals, namely ROS generation, in a cell free system and NADPH oxidase derived superoxide (O2-) generation in vascular tissue (rat aorta). Danshen extracts, both aqueous and ethanol, and their active compounds (Tanshinone IIA, Salvianolic Acid B and Danshensu) demonstrated anti-oxidant activity however findings exhibited stronger activity in a cell free system than in the aortic vascular tissue.
138p
runthenight07
01-03-2023
6
2
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Class II phosphoinositide 3-kinase α-isoform (PI3K-C2α) is involved in regulating KCl-induced vascular smooth muscle contraction. The current study was to investigate the effects of sevoflurane (SEVO) and isoflurane (ISO) on KCl-elicited PI3KC2α mediated vasoconstriction in rat aortic smooth muscle.
10p
viottohahn
30-03-2022
8
1
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The mechanism of volatile anesthetics on vascular smooth muscle (VSM) contraction in the setting of diabetes mellitus (DM) remains unclear. The current study was designed to determine the efects of sevofurane (SEVO) and isofurane (ISO) on phosphoinositide 3-kinase (PI3K) and Rho kinase (ROCK) mediated KCl-induced vasoconstriction in aged type 2 diabetic rats.
8p
vidietmarhopp
29-12-2021
13
0
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The sensitivity of the medulla spinalis to ischemia and reperfusion has been shown in previous in vitro and in vivo studies. However, less is known about the effects of carvacrol administration following ischemia and reperfusion. It was hypothesized that carvacrol might have protective effects on motor neuron functionunder ischemia- and reperfusion-induced oxidative stress.
6p
dolomite36
30-12-2021
5
0
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Vasodilators are important pharmacologic agents for managing and/or treating hypertension. Medicinal plants are considered as valuable source of bioactive compounds. We used a bioguided approach to isolate, identify, and investigate the possible vasodilation activities and mechanism(s) of the prepared methanol extract from aerial parts of Psiadia punctulata (MAPP), its bioactive fraction and active compounds.
7p
partimesinhvien
08-05-2020
12
0
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An area of ongoing controversy is the role adenosine to regulate vascular tone in conduit vessels that regulate compliance, and the role of nitric oxide (NO), potassium channels and receptor subtypes involved.
11p
vienzym2711
30-03-2020
10
2
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Lipid emulsions are widely used for the treatment of systemic toxicity that arises from local anesthetics. The goal of this in vitro study was to examine the cellular mechanism associated with the lipid emulsion-mediated attenuation of vasodilation induced by a toxic dose of bupivacaine in isolated endothelium-denuded rat aorta.
10p
vivalletta2711
11-01-2020
10
0
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The effect of geteratisin (3–200 micromol/L) and 6–O–benzoylgeteratisin (10–250 micromol/L) on the contractile activity of the rat aorta smooth muscle cells (SMC) was studied. Isometric tension forces were recorded using a force transducer FT–03 (Grass Instrument Co., USA). In the experiments it was revealed that vasorelaxant effect of heteratisine is mainly associated with the blockade of Ca2+L–channel, receptor–operated Ca2+ –channels (ROCC), and store–operated Ca2+–channels (SOCC).
7p
quenchua2
15-12-2019
8
0
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The goal of this in vitro study was to examine the effects of pre-acidification and pre-akalinization on the lipid emulsion-mediated reversal of toxic dose levobupivacaine-induced vasodilation in isolated rat aorta. Isolated aortic rings with and without the nitric oxide synthase inhibitor Nω-nitro-L-arginine methyl ester (L-NAME) were exposed to four types of Krebs solution (pH 7.0, 7.2, 7.4, and 7.6), followed by the addition of 60 mM potassium chloride.
9p
viwashington2711
04-12-2019
9
1
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The goal of this in vitro study was to examine the effect of the alpha-2 adrenoceptor agonist dexmedetomidine on phenylephrine (alpha-1 adrenoceptor agonist)-induced contraction in isolated rat aortae and to elucidate the associated cellular mechanisms, with a particular focus on alpha-1 adrenoceptor antagonism.
8p
vilusaka2711
19-11-2019
9
0
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Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Mechanism of UV light-induced photorelaxation in isolated rat aorta
6p
hoami_266
15-09-2011
42
2
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