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Real world evidence
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In this study, we conducted a systematic literature review (SLR) to qualitatively summarize the effectiveness and safety of treatment regimens in the real-world setting after 1 L treatment with CDK4/6i in patients with HR+/HER2- LABC/mBC.
12p
vishanshan
27-06-2024
2
1
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Patients with metastatic gastric cancer (mGC) have poor prognosis. This real-world study aimed to describe treatment regimens and survival of mGC patients. In addition, HER2-positive mGC patients actively treated with targeted therapy were identified, and relevant outcomes were described.
9p
vishanshan
27-06-2024
1
1
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Patients from non-small cell lung cancer (NSCLC) controlled clinical trials do not always reflect realworld heterogeneous patient populations. We designed a study to describe the real-world patient characteristics and treatment patterns of first-line treatment in patients in the US with NSCLC.
14p
vishanshan
27-06-2024
2
1
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With geographical impedance becoming the major barrier preventing patients from getting timely healthcare service, this study incorporated health seeking behavior in estimating spatial accessibility of relative scarce LDCT resource in China, thus to provide real-world evidence for future government investment and policy making.
11p
vishanshan
27-06-2024
1
1
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This study aimed to investigate the efficacy of third-line chemotherapy re-use by the comparison with that of anti-angiogenic monotherapy, and further find the population more suitable for third-line chemotherapy.
13p
vishanshan
27-06-2024
1
1
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In chronic lymphocytic leukaemia (CLL), comorbidities assessed by the CLL comorbidity index (CLL-CI) have been associated with outcomes in Western cohorts. We conducted a retrospective analysis of an unselected Middle Eastern cohort of newly diagnosed CLL patients seen at the Kuwait Cancer Control Center (n=300).
7p
vishanshan
27-06-2024
2
1
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Ebook Incident response & computer forensics (2nd Ed) - Part 1 includes contents: Chapter 1 real-world incidents, chapter 2 introduction to the incident response process, chapter 3 preparing for incident response, chapter 4 after detection of an incident, chapter 5 live data collection from Windows systems, chapter 6 live data collection from Unix systems, chapter 7 forensic duplication, chapter 8 collecting network-based evidence, chapter 9 evidence handling.
246p
longtimenosee05
31-03-2024
1
0
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The American College of Medical Genetics and Genomics (ACMG)/Association for Molecular Pathology (AMP) guidelines recommend using variant enrichment among cases as "strong" evidence for pathogenicity per the PS4 criterion. However, quantitative support for PS4 thresholds from real-world Mendelian case–control cohorts is lacking.
14p
vicwell
29-02-2024
3
2
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A multicenter real-world evidence study in the Swiss treatment landscape of chronic myeloid leukemia
The real-world experience of Swiss chronic myeloid leukemia (CML) patients treated with tyrosine kinase inhibitors (TKIs) is largely unknown, in particular with regard to achievement of response per European Leukemia Net (ELN) criteria and adherence to ELN recommendations.
13p
vileonardodavinci
23-12-2023
5
2
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There is limited real-world evidence that describes patients with newly diagnosed multiple myeloma (NDMM) treated with the bortezomib, lenalidomide, and dexamethasone (VRd) triplet regimen. We evaluated patient characteristics and treatment outcomes among nontransplanted NDMM patients who received VRd as their first line of therapy (LOT) in US oncology practice settings.
9p
vialfrednobel
23-12-2023
9
5
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Ebook "Why managers and companies take risks" uses risk in its dictionary meaning as the probabiHty of an unde sirable outcome, and has two research questions: when managers make de cisions, what leads them to choose a risky alternative? and: what deter mines whether the decision proves correct? Answers to these questions form a model of decision making that explains the process and results of managers' risk-taking in the real world.
351p
loivantrinh
29-10-2023
7
2
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The landscape of non-small cell lung cancer (NSCLC) therapy is rapidly changing. This analysis aimed to understand patient characteristics, diagnosis and treatment patterns in patients with metastatic NSCLC (mNSCLC) without EGFR and ALK mutations across fve European countries.
20p
vioracle
29-09-2023
4
3
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With growing availability of digital health data and technology, health-related studies are increasingly augmented or implemented using real world data (RWD). Recent federal initiatives promote the use of RWD to make clinical assertions that influence regulatory decision-making.
6p
visteverogers
24-06-2023
2
2
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We aim to develop a hybrid model for earlier and more accurate predictions for the number of infected cases in pandemics by (1) using patients’ claims data from different counties and states that capture local disease status and medical resource utilization; (2) utilizing demographic similarity and geographical proximity between locations; and (3) integrating pandemic transmission dynamics into a deep learning model.
11p
vighostrider
25-05-2023
7
2
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Glycemic control is an important component of critical care. We present a data-driven method for predicting intensive care unit (ICU) patient response to glycemic control protocols while accounting for patient heterogeneity and variations in care.
9p
vighostrider
25-05-2023
5
2
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The study sought to conduct an informatics analysis on the National Evaluation System for Health Technology Coordinating Center test case of cardiac ablation catheters and to demonstrate the role of informatics approaches in the feasibility assessment of capturing real-world data using unique device identifiers (UDIs) that are fit for purpose for label extensions for 2 cardiac ablation catheters from the electronic health records and other health information technology systems in a multicenter evaluation.
10p
vighostrider
25-05-2023
5
3
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Advances in standardization of observational healthcare data have enabled methodological breakthroughs, rapid global collaboration, and generation of real-world evidence to improve patient outcomes. Standardizations in data structure, such as use of common data models, need to be coupled with standardized approaches for data quality assessment.
7p
vighostrider
25-05-2023
2
2
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We identified challenges and solutions to using electronic health record (EHR) systems for the design and conduct of pragmatic research. We are hopeful our collection of specific EHR challenges and research needs will drive health system leaders, policymakers, and EHR designers to support these suggestions to improve our national capacity for generating real-world evidence.
15p
vighostrider
25-05-2023
4
2
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This study sought both to support evidence-based patient identity policy development by illustrating an approach for formally evaluating operational matching methods, and also to characterize the performance of both referential and probabilistic patient matching algorithms using real-world demographic data.
7p
vighostrider
25-05-2023
3
2
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The US Food and Drug Administration (FDA) created the Sentinel System in response to a requirement in the FDA Amendments Act of 2007 that the agency establish a system for monitoring risks associated with drug and biologic products using data from disparate sources. The Sentinel System has completed hundreds of analyses, including many that have directly informed regulatory decisions.
10p
vighostrider
25-05-2023
2
2
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