Recombination hotspots
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Rare intronic variants of TCF7L2 arising by selective sweeps in an indigenous population from Mexico
Genetic variations of the TCF7L2 gene are associated with the development of Type 2 diabetes (T2D). The associated mutations have demonstrated an adaptive role in some human populations, but no studies have determined the impact of evolutionary forces on genetic diversity in indigenous populations from Mexico.
15p vinarcissa 21-03-2023 1 1 Download
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Chromatin loops form a basic unit of interphase nuclear organization, with chromatin loop anchor points providing contacts between regulatory regions and promoters. However, the mutational landscape at these anchor points remains under-studied. Here, we describe the unusual patterns of somatic mutations and germline variation associated with loop anchor points and explore the underlying features influencing these patterns.
14p vigalileogalilei 27-02-2022 15 1 Download
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Recombination plays an important evolutionary role by breaking up haplotypes and shuffling genetic variation. This process impacts the ability of selection to eliminate deleterious mutations or increase the frequency of beneficial mutations in a population.
16p vijeeni2711 24-07-2021 14 0 Download
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Critical assessment of coalescent simulators in modeling recombination hotspots in genomic sequences
Coalescent simulation is pivotal for understanding population evolutionary models and demographic histories, as well as for developing novel analytical methods for genetic association studies for DNA sequence data. A plethora of coalescent simulators are developed, but selecting the most appropriate program remains challenging.
14p viwyoming2711 16-12-2020 9 0 Download
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As a fundamental genomic element, meiotic recombination hotspot plays important roles in life sciences. Thus uncovering its regulatory mechanisms has broad impact on biomedical research. Despite the recent identification of the zinc finger protein PRDM9 and its 13-mer binding motif as major regulators for meiotic recombination hotspots, other regulators remain to be discovered.
12p vikentucky2711 26-11-2020 7 0 Download
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: High recombination rates and hotspots in a Plasmodium falciparum genetic cross...
15p thulanh22 20-11-2011 46 3 Download
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Detecting sequence polymorphisms associated with meiotic recombination hotspots in the human genome...
15p thulanh22 20-11-2011 45 1 Download
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: PRDM9 points the zinc finger at meiotic recombination hotspots...
0p thulanh21 15-11-2011 30 1 Download
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Hotspots of homologous recombination in the human genome: not all homologous sequences are equal...
4p thulanh19 09-11-2011 53 1 Download