Recurrent pancreatic cancer

The international consensus guidelines for intraductal papillary mucinous neoplasm of the pancreas (IPMN) presented clinical features as indications for surgery. Whereas surveillance for recurrence, including de novo lesions, is essential, optimal surveillance protocols have not been established.

10p visusanwojcicki 28-06-2022 8 1   Download

Prognosis for patients recurred rapidly after resection of pancreatic ductal adenocarcinoma (PDAC) was extremely poor. We proposed the concept of postoperative hyper-progression disease (PO-HPD) to define recurrence within 2months after surgery, explored the role of surgery for postoperative HPD patients and determined the predictive preoperative risk factors and genomic features of PO-HPD.

14p visusanwojcicki 28-06-2022 7 1   Download

Cancer stem cells (CSCs) are implicated in carcinogenesis, cancer progression, and recurrence. Several biomarkers have been described for pancreatic ductal adenocarcinoma (PDAC) CSCs; however, their function and mechanism remain unclear.

19p vimahuateng 26-11-2021 6 0   Download

Paclitaxel (Taxol) is a microtubule-stabilizing drug used to treat several solid tumors, including ovarian, breast, non-small cell lung, and pancreatic cancers. The current treatment of ovarian cancer is chemotherapy using paclitaxel in combination with carboplatin as a frontline agent, and paclitaxel is also used in salvage treatment as a second line drug with a dose intensive regimen following recurrence.

13p vimahuateng 26-11-2021 8 0   Download

Pancreatic cancer has highly aggressive features, such as local recurrence that leads to significantly high morbidity and mortality and recurrence after successful tumour resection. Intraoperative radiation therapy (IORT), which delivers targeted radiation to a tumour bed, is known to reduce local recurrence by directly killing tumour cells and modifying the tumour microenvironment.

12p vimahuateng 26-11-2021 9 0   Download

Herein, we investigate the relationship between pancreatic stem cell markers (PCSC markers), CD44, and epithelial-specific antigen (ESA), tumor stroma, and the impact on recurrence outcomes in pancreatic ductal adenocarcinoma (PDAC) patients.

11p vianrose2711 27-04-2021 8 1   Download

Although postoperative adjuvant chemoradiotherapies prevent recurrence for some patients with ampullary cancer, the recurrence rate is as high as 29 % in patients with stage I cancer. In an effort to identify predictors of recurrence in patients with ampullary adenocarcinoma, we investigated the clinical value of assessing standard and variant forms of CD44.

10p vimoscow2711 29-08-2020 7 1   Download

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies today with an urgent need for novel therapeutic strategies. Biomarker analysis helps to better understand tumor biology and might emerge as a tool to develop personalized therapies.

9p vimale2711 21-08-2020 9 0   Download

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers with high metastatic potential. Clinical observations suggest that there is disease heterogeneity among patients with different sites of distant metastases, yielding distinct clinical outcomes.

8p vimanila2711 29-06-2020 8 0   Download

Label-retaining cancer cells (LRCC) have been proposed as a model of slowly cycling cancer stem cells (CSC) which mediate resistance to chemotherapy, tumor recurrence, and metastasis. The molecular mechanisms of chemoresistance in LRCC remain to-date incompletely understood.

15p vimanila2711 29-06-2020 6 1   Download

Pancreatic cancer is a highly malignant tumor with a poor prognosis. Chemotherapy such as gemcitabine is still an important treatment. Gemcitabine (Gem) may prolong survival time and delay the development of recurrent disease after complete resection of pancreatic cancer.

8p vimanila2711 25-06-2020 5 0   Download

Oesophageal cancer has a high metastatic potential and poor prognosis, with a significant risk of recurrence after radical resection. However, resected pancreatic metastasis from oesophageal cancer is rare.

5p viputrajaya2711 22-06-2020 5 0   Download

Invasive pancreatic neoplasms have a high propensity for recurrence even after curative resection. Recently, patients who underwent pancreatectomy have an opportunity of undergoing secondary pancreatic resection, so-called “repeat pancreatectomy” to achieve curative operation and prolong their survival.

9p vikuala271 13-06-2020 7 1   Download

Immune checkpoint inhibitors (ICIs) have achieved unprecedented success in cancer treatment over the past decade. The application of ICIs hasled to the discovery of various types of immune-related adverse events (irAEs).

5p vikuala271 13-06-2020 12 1   Download

Only a few patients with pancreatic ductal adenocarcinoma (PDAC) recurring after curative resection and peri-operative (neoadjuvant and adjuvant) therapy are included in clinical trials of metastatic PDAC.

9p vikuala271 13-06-2020 10 0   Download

Over many years, the petrochemical industry has built up an effective infra- structure for processing and distributing hydrocarbon-based products. Due to reliance on imported crude oil, much of the U.S. infrastructure is geographically located around the coastline (Fig. 9). Thus, many current processing facilities are not well situated for the collection of large volumes of plant-derived material. Where plant materials are processed in lumber mills, oil crushers, or corn wet mills, these are situated adjacent to areas of supply.

20p loixinloi 08-05-2013 62 4   Download

When someone arrives at a web site, you have a limited amount of attention available. How much time that equates to is unknown. It depends on the competition, visitor's expectations, and how badly they need what your site offers. And when you only have a limited amount of attention, there is a limit to the number of signals you can convey. So aim to make every signal relevant, significant, and helpful . The more efficiently you can communicate what you have to get across, the more likely you are to keep your visitor's attention, and the greater your success.

6p seketnoi 29-04-2013 110 7   Download

According to financial aid officials at 2-year and less-than-2-year schools we visited, prior to the Direct Loan Program, some FFELP lenders refused to lend to students at their schools because some of their graduates did not repay their loans on time. In contrast, financial aid officials at public and private 4-year schools we visited said that they did not have any problems finding lenders to serve their students, and FFELP lenders actively marketed their products to them and their students....

105p dacotaikhoan 26-04-2013 32 2   Download

So long as there is no international government; so long as there is anarchy between states; so long can there be no permanent local, municipal, domestic law in one state either. Just as there are frontieres sans medicins, so politics has few real frontiers. Many non- governmental organisations are financed by other countries’ governments for governmental purposes, not all of them benign. Things fall apart. Unannounced, and confused with the ordinary, war will fly in a window on a lazy September day. From confusion to fusion: the next nine-eleven will be nuclear, of course.

11p hoangphiyeah1tv 18-04-2013 43 4   Download

The algorithms for all the relational operators are written as if they were to be run on a single processor. As shown in Figure 3, the input to an Operator Process is a stream of tuples and the output is a stream of tuples that is demultiplexed through a structure we term a split table. Once the process begins execution, it continuously reads tuples from its input stream, operates on each tuple, and uses a split table to route the resulting tuple to the process indicated in the split table. 4 When the process detects the end of its input stream, it first closes the output...

165p nhacsihuytuan 13-04-2013 35 2   Download