Recurrent pancreatic cancer

Only a few patients with pancreatic ductal adenocarcinoma (PDAC) recurring after curative resection and peri-operative (neoadjuvant and adjuvant) therapy are included in clinical trials of metastatic PDAC.

9p vikuala271 13-06-2020 3 0   Download

Pancreatic cancer is a highly malignant tumor with a poor prognosis. Chemotherapy such as gemcitabine is still an important treatment. Gemcitabine (Gem) may prolong survival time and delay the development of recurrent disease after complete resection of pancreatic cancer.

8p vimanila2711 25-06-2020 3 0   Download

Label-retaining cancer cells (LRCC) have been proposed as a model of slowly cycling cancer stem cells (CSC) which mediate resistance to chemotherapy, tumor recurrence, and metastasis. The molecular mechanisms of chemoresistance in LRCC remain to-date incompletely understood.

15p vimanila2711 29-06-2020 2 0   Download

Neither randomized clinical trials nor meta- analysis are available and evidence is based on a number of retrospective studies with multivariate for mortality risk factors or data from national cancer registries (Gilliland et al., 1997; Hundahl et al., 1998). Unfortunately, very remarkable differences in patient’s selection, staging systems, and clinical management affect the available studies. In particular, radioiodine treatment is not routinely carried out in a standard manner and outcome results of different studies are thus not comparable (Sciuto et al., 2009).

180p wqwqwqwqwq 20-07-2012 71 5   Download

Even incremental contributions to realizing improved health outcomes will deliver substantial social and economic benefits. When the funding request of $100 million for Canadian child health genomics research is compared to the short and long term benefits, it clearly delivers significant returns on investment. However, it must not be forgotten that it is fundamentally the lives of children that are at issue.

5p connhobinh 10-12-2012 42 0   Download

Invasive pancreatic neoplasms have a high propensity for recurrence even after curative resection. Recently, patients who underwent pancreatectomy have an opportunity of undergoing secondary pancreatic resection, so-called “repeat pancreatectomy” to achieve curative operation and prolong their survival.

9p vikuala271 13-06-2020 1 0   Download

Immune checkpoint inhibitors (ICIs) have achieved unprecedented success in cancer treatment over the past decade. The application of ICIs hasled to the discovery of various types of immune-related adverse events (irAEs).

5p vikuala271 13-06-2020 3 0   Download

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers with high metastatic potential. Clinical observations suggest that there is disease heterogeneity among patients with different sites of distant metastases, yielding distinct clinical outcomes.

8p vimanila2711 29-06-2020 3 0   Download

This process of cohort succession is thus increasing the average literacy rate of the population 60 and older over time. In addition, Phnom Penh elderly represent a larger share of the SEC sample than of the national population of elderly and, as indicated above, since the literacy level of Phnom Penh elderly is above the national average, this also has the effect of raising the average literacy level compared to nationally representative census results. However when tabulations of SEC are limited to persons 66 and older to correspond to the cohorts who were 60 and older in 1998, the...

78p ut_hai_can 26-12-2012 72 17   Download

Herein, we describe a novel method that addresses the above-mentioned problems, namely, a semi-intact cell assay coupled with green fluorescence protein (GFP)-visualization techniques. By using the semi-intact cell system, we can observe the morphological changes that occur in “preexisting” organelles during mitosis more easily, and, at the same time, can investigate the effects of exogenously added antibodies, drugs, and recombinant proteins on the process.

330p yeutinh98 22-09-2012 39 7   Download

When someone arrives at a web site, you have a limited amount of attention available. How much time that equates to is unknown. It depends on the competition, visitor's expectations, and how badly they need what your site offers. And when you only have a limited amount of attention, there is a limit to the number of signals you can convey. So aim to make every signal relevant, significant, and helpful . The more efficiently you can communicate what you have to get across, the more likely you are to keep your visitor's attention, and the greater your success.

6p seketnoi 29-04-2013 80 7   Download

Admission to veterinary programmes around the globe is a highly competitive process, with candidates typically required to attain top grades in science-based subjects to qualify for entry. Owing to the large number of applicants to veterinary schools, interviews often form part of the selection process. Although curricula will vary from provider to provider, veterinary programmes are extremely intensive courses of study and typically include pre- clinical, para-clinical and clinical components.

256p wqwqwqwqwq 23-07-2012 41 5   Download

In much of the developing world, health systems at the local level are fundamentally failing to sustain and improve the lives of women. In many cases women are the last to receive adequate health care and are dying because of it. Women are dying because they do not have access to emergency obstetric care when they require it. Women are at risk because their nation, province or village has not placed sufficient priority on ensuring that they are protected from the threat of contracting HIV/AIDS.

12p connicquy 20-12-2012 39 5   Download

This paper provides an overview of the main program of Bank diagnostic work in the field of private sector financial reporting: the Reports on the Observance of Standards and Codes (ROSC) accounting and auditing assessment. It summarizes some of the main findings of the 38 assessments that have been carried out to date, with specific reference to the challenges to the successful implementation of international accounting and auditing standards.

10p taisaovanchuavo 26-01-2013 55 5   Download

The most radical example is beyond a doubt the apparently heretical confrontation of John Ford’s The Searchers (1956) with Clyfford Still’s large abstract paintings.

5p khanhchilam 01-04-2013 48 5   Download

I tiptoed through the sitting room, headed for my room and my soft and wondrous bed. I was nearly to my door when someone hissed at me from the sofa, making me jump so high I nearly fell over. I whirled and found my sister sitting there. Cora was two years younger than me, and, unlike me, she was brilliant at school, a right square. She brought home test papers covered in checkmarks and smiley-faces, and her teachers often asked her to work with thick students to help them get their grades up. I had shown her how to use my edit-suite when she was only...

57p hongphuocidol 03-04-2013 28 5   Download

The tendinous chords, as functional extensions of the papillary muscles, perform the dual function of maintaining valvular competence by preventing leaflet prolapse and maintaining ventricular geometry by providing cross-ventricular support. The chords originate from the apical portions of the papillary muscles or directly from the posterior ventricular wall. They insert either into the free edge of the leaflets or on their ventricular surface. Chords have been characterized a number of ways.

256p wawawawawa 27-07-2012 62 4   Download

Arts-related real estate markets have paradoxical entry barriers and advantages. There are barriers inherent in the uncertainty of demand, zoning issues and the costs of retrofitting old systems. At the same time, entry barriers are lowered because the space demand is flexible and often requires minimal high-end fixtures and adaptations. Art-making, performance, craft production and exhibition spaces attract users who want to adapt and re-create space in flexible ways.

0p quaivattim 01-12-2012 45 4   Download

The study provides information on key reproductive and sexual health indicators in young women and men age 15-24 in 38 developing countries. The data come from Demographic and Health Surveys (DHS) and AIDS Indicator Surveys (AIS) conducted between 2001 and 2005. Indicators are selected for the following key areas: background characteristics; adolescent pregnancy; contraception; sexual activity; and HIV/AIDS-related knowledge, attitudes, and behaviors. Additional analysis examines the association of various individual and household characteristics with the key indicators.

107p thankinhphanliet 21-12-2012 53 4   Download

To help ensure accurate measurements, Region 9 recommends that these guidelines be followed whenever VOCs in soil or other solid matrices are sampled and analyzed. These guidelines address methods for: (1) handling of samples as intact soil cores; (2) preserving samples; (3) storing samples in hermetically sealed containers; and (4) minimizing analyte losses due to direct volatilization (both in the field and the laboratory) and biodegradation.

6p cao_can 02-01-2013 40 4   Download