Regenerative medical application

Ebook "Regenerative medicine and cell therapy" discusses cutting-edge science in the field of regenerative biomedicine and its therapeutic applications to various medical disorders. The chapters are written by renowned scientists in the specific fields. This will be a useful book for basic and clinical scientists, especially young investigators and stem cell biology students who are newly entering the world of stem cells research.

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Ebook "Regenerative biology of the eye" is a comprehensive look at the current knowledge on stem cell application for vision loss, showcasing different types of stem cells (adult, embryonic, iPSCs) for diseases of the front and the back of the eye. It also highlights data obtained in various models from fish to human, as well as from the bionic eye project for vision regeneration.

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Ebook "Mesenchymal stromal cells: Biology and clinical applications" have also been subject to controversy and increasing scrutiny as new mechanisms of action are reported and ever-expanding therapeutic applications pursued. In this book, leading authorities from all over the world, who are actively involved in this field, provide state-of-the-art knowledge of the basic biology, translational requirements and latest clinical experience with MSCs.

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Human corneal endothelial cells have two major functions: barrier function mediated by proteins such as ZO-1 and pump function mediated by Na-K-ATPase which help to maintain visual function. However, human corneal endothelial cells are notorious for their limited proliferative capability in vivo and are therefore prone to corneal endothelial dysfunction that eventually may lead to blindness.

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Tissue Engineering is the first medical therapy where engineered tissues could potentially become fully integrated within the patient, thus offering a permanent cure for many diseases not curable today. The National Science Foundation (NSF) defined Tissue Engineering in 1988 as the “application of the principles and methods of engineering and life sciences toward fundamental understanding of structure-function relationships in normal and pathological mammalian tissues and the development of biological substitutes to restore, maintain or improve tissue function (Shalak and Fox, 1988).

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Organ damage and the resultant inflammatory responses initiate a series of repair processes, including stem cell proliferation, migration, and differentiation, often in combination with angiogenesis and remodeling of the extracellular matrix. Endogenous stem cells in tissues such as liver and skin have a remarkable ability to regenerate the organs, whereas heart and brain have a much more limited capability for self-repair. Under rare circumstances, circulating stem cells may contribute to regenerative responses by migrating into a tissue and differentiating into organ-specific cell types.

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