Regulatory genes
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This paper addresses the problem of estimating the time series of a gene expression using nonlinear Bayesian filtering algorithms. The response of gene regulatory networks (GRNs) to functional requirements in the cell and environmental conditions evolves over time. Dynamic biological processes such as cancer progression and treatment recovery depend on the collected genetic profiles. These processes are behind genetic interactions that rewire over the course of time.
19p tovann 23-07-2024 0 0 Download
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Part 2 book "Microinjection methods and applications" includes content: Germline transformation of caenorhabditis elegans by injection, quantitative microinjection of mouse oocytes and eggs, microinjection of follicle enclosed mouse oocytes, functional studies of regulatory genes in the sea urchin embryo, exploring the cytoskeleton during intracytoplasmic sperm injection in humans,... and other contents.
107p dianmotminh05 23-07-2024 2 0 Download
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Part 2 book "Next generation microarray bioinformatics - Methods and protocols" includes content: Modeling gene regulation networks using ordinary differential equations; nonhomogeneous dynamic bayesian networks in systems biology, inference of regulatory networks from microarray data with, and the bioconductor package qpgraph; effective non linear methods for inferring genetic regulation from time series microarray gene expression data;... and other contents.
219p dianmotminh04 16-07-2024 2 1 Download
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Gastric cancer (GC) is one of the most prevalent malignant tumors worldwide and is associated with high morbidity and mortality rates. However, the specific biomarkers used to predict the postoperative prognosis of patients with gastric cancer remain unknown. Recent research has shown that the tumor microenvironment (TME) has an increasingly positive effect on anti-tumor activity. This study aims to build signatures to study the effect of certain genes on gastric cancer.
17p vishanshan 27-06-2024 2 2 Download
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Resveratrol has demonstrated its ability to regulate BRCA1 gene expression in breast cancer cells, and previous studies have established the binding of MBD proteins to BRCA1 gene promoter regions. The aimed to evaluate the impact of MBD proteins on the regulation of BRCA1, BRCA2, and p16 genes and their consequential effects on breast cancer cells.
18p vishanshan 27-06-2024 3 2 Download
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Hepatocellular carcinoma (HCC) has a high mortality rate, and the mechanisms underlying tumor development and progression remain unclear. However, inactivated tumor suppressor genes might play key roles. DNA methylation is a critical regulatory mechanism for inactivating tumor suppressor genes in HCC.
19p vishanshan 27-06-2024 3 1 Download
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This study aims to identify functionally relevant lncRNAs impacting OS proliferation and lipid metabolism and seeks to shed light on the upstream regulatory mechanisms governing lipogenic enzyme activity. Based on comprehensive bioinformatic analysis and the establishment of a risk model, we identified seven lncRNAs signifcantly associated with clinical characteristics and lipid metabolism-related genes in patients with OS.
15p vikoch 27-06-2024 2 1 Download
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Ebook "Modeling in systems biology: The petri net approach" aims to meet a challenge that previously has been largely avoided by the Petri net community. The community used to be content with the demonstration that Petri nets were able to simulate quite a large number of partial systems when their homogeneity permitted a rather restricted application of the Petri net methodology. The proof of principle used to say that Petri net models can simulate otherwise established theoretical descriptions.
378p ladongphongthanh1008 22-04-2024 4 2 Download
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Ebook "Frontiers in computational and systems biology" consists of 19 chapters and covers a wide spectrum of topics. Described applications of an RNA structure sampling algorithm to the rational design of short interfering RNAs for gene silencing by RNA interference and to target identification for microRNAs that play important roles in posttranscriptional gene regulation.
411p ladongphongthanh1008 22-04-2024 6 2 Download
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Ebook "Mitochondrial oxidative phosphorylation: Nuclear-encoded genes, enzyme regulation, and pathophysiology" focuses on new developments in mitochondrial morphology, biogenesis, and evolution, as well as in structure and regulatory functions of the enzyme complexes of OxPhos by experts in their fi elds. Particular emphasis is given to the oxygen consuming enzyme of the respiratory chain, cytochrome c oxidase, representing a controlling step of OxPhos.
378p tracanhphuonghoa1007 22-04-2024 4 2 Download
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Genome–phenome studies have identified thousands of variants that are statistically associated with disease or traits; however, their functional roles are largely unclear. A comprehensive investigation of regulatory mechanisms and the gene regulatory networks between phenome-wide association study (PheWAS) and genomewide association study (GWAS) is needed to identify novel regulatory variants contributing to risk for human diseases.
15p vibransone 28-03-2024 4 3 Download
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Only a small fraction of patients respond to the drug prescribed to treat their disease, which means that most are at risk of unnecessary exposure to side effects through ineffective drugs. This inter-individual variation in drug response is driven by differences in gene interactions caused by each patient’s genetic background, environmental exposures, and the proportions of specific cell types involved in disease.
15p vibransone 28-03-2024 4 2 Download
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Genomic structural variants (SVs) can affect many genes and regulatory elements. Therefore, the molecular mechanisms driving the phenotypes of patients carrying de novo SVs are frequently unknown.
15p vibransone 28-03-2024 5 2 Download
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In cancer, normal epigenetic patterns are disturbed and contribute to gene expression changes, disease onset, and progression. The cancer epigenome is composed of the epigenetic patterns present in the tumor-initiating cell at the time of transformation, and the tumor-specific epigenetic alterations that are acquired during tumor initiation and progression.
19p vibransone 28-03-2024 4 2 Download
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We present an assay to experimentally test the regulatory effects of genetic variants within transcripts using CRISPR/ Cas9 followed by targeted sequencing. We applied the assay to 32 premature stop-gained variants across the genome and in two Mendelian disease genes, 33 putative causal variants of eQTLs, and 62 control variants in HEK293T cells, replicating a subset of variants in HeLa cells.
10p vibransone 28-03-2024 7 2 Download
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Tight regulatory loops orchestrate commitment to B cell fate within bone marrow. Genetic lesions in this gene regulatory network underlie the emergence of the most common childhood cancer, acute lymphoblastic leukemia (ALL). The initial genetic hits, including the common translocation that fuses ETV6 and RUNX1 genes, lead to arrested cell differentiation.
25p vibransone 28-03-2024 6 1 Download
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Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes (T2D). However, the underlying biological mechanisms for many of these associations remain unknown. GWAS signals close to the glucokinase regulatory protein gene (GCKR) have been reported for lipid and glucose metabolism traits and the risk of T2D.
14p vioraclene 31-03-2024 5 3 Download
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The identification of functional non-coding mutations is a key challenge in the field of genomics. Here we introduce μ-cisTarget to filter, annotate and prioritize cis-regulatory mutations based on their putative effect on the underlying “personal” gene regulatory network.
13p vioraclene 31-03-2024 4 2 Download
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Alterations in genetic and epigenetic landscapes are known to contribute to the development of different types of cancer. However, the mechanistic links between transcription factors and the epigenome which coordinate the deregulation of gene networks during cell transformation are largely unknown.
16p vioraclene 31-03-2024 2 2 Download
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The liver X receptors (LXRs, NR1H2 and NR1H3) and peroxisome proliferator-activated receptor gamma (PPARG, NR1C3) nuclear receptor transcription factors (TFs) are master regulators of energy homeostasis. Intriguingly, recent studies suggest that these metabolic regulators also impact tumor cell proliferation.
16p vioraclene 31-03-2024 5 2 Download