Related compounds

This history of antimicrobials is marked with impressive discoveries, the majority of which have their origin in natural products. However in this work, the antimicrobial activity of β- nitrostyrenes and related compounds of synthetic origin is reviewed and investigated with a particular focus on the influence of fluorine functionality. Various fluorinated β-methyl-β-nitrostyrene compounds were prepared, their minimum inhibition concentration in cultures of Gram positive, Gram negative and a fungus and their lipophilicity was determined.

133p runthenight05 01-03-2023 5 3   Download

This thesis documents a research program in which Australian grown Danshen extracts and related bioactive compounds have been demonstrated to be effective in scavenging free radicals, namely ROS generation, in a cell free system and NADPH oxidase derived superoxide (O2-) generation in vascular tissue (rat aorta). Danshen extracts, both aqueous and ethanol, and their active compounds (Tanshinone IIA, Salvianolic Acid B and Danshensu) demonstrated anti-oxidant activity however findings exhibited stronger activity in a cell free system than in the aortic vascular tissue.

138p runthenight07 01-03-2023 9 3   Download

Master's thesis of Science "Investigation into the modulation of circadian clock proteins by dietary compounds and small molecules" is structured as follows: Chapter 1 Introduction; Chapter 2 Identification of novel bioactive compounds from Olea europaea by evaluation of chemical compounds in the OliveNetTM library: in silico bioactivity and molecular modelling, and in vitro validation of hERG activity; Chapter 3 Modulation of circadian core clock proteins by dietary compounds; Chapter 4 Molecular mechanisms of action of selected olive phenolics against epigenetic modifiers and the structur...

235p runthenight04 02-02-2023 3 2   Download

This paper demonstrates that for a CNN it is vice-versa, in which concatenation is better for CDR classification. To this end, we develop a CNN based model with multiple input concatenated for CDR classification. Experimental results on the benchmark dataset demonstrate its outperformance over other recent state-of-the-art CDR classification models.

6p tamynhan6 14-09-2020 16 4   Download

Tetravalent chemistry: Inorganic. This chapter gives an overview on the chemistry of tetravalent lanthanide compounds, especially those of tetravalent cerium. Following a brief Introduction it covers the tetrahalides, dioxides and other lanthanides(IV) salts. Coordination compounds of cerium in the oxidation state +4 include halogeno complexes and complexes of oxo acids, β-diketonates and related Schiff-base complexes as well as porphyrinates and related complexes.

13p duchlpr 01-05-2018 23 0   Download

Hydrotalcite-type (HT) materials based on ZnAlO and MgAlO have been prepared and investigated by various physico-chemical method: IR, XRD, BET... It was found that the HT structure depended on the nature and the atom ratio of the metals. The adsorption ability of the materials was tested with the reactive dyes Red 3BA as a model compound. The results indicated that the materials with the HT structure and atom ratio of Me2+ /Me3+ = 3 : 1 calcinated at < 500o C have the highest dyes removal. That could be related with the chemical characterization.

5p uocvong04 24-09-2015 79 5   Download

Template reactions play a very important role in the formation of many natural macro- heterocyclic compounds that have biological activities such as porphyrine, metalloenzyme etc. and become one type of the most important reactions in bioinorganic Chemistry and other relating fields.

5p uocvong03 24-09-2015 49 2   Download

Uridine-5¢-diphospho-1-a-D-glucose (UDP-Glc) is a common substrate used by glucosyltransferases, including certain bacterial toxins such as Toxins A and B from Clostridium difficile. Fluorescent analogs of UDP-Glc have been prepared for use in our studies of the clostridial toxins. These compounds are related to the methylanthraniloylATP compounds commonly used to probe the chemistry of ATP-dependent enzymes. The reaction of excess methylisatoic anhydride with UDP-Glc in aqueous solution yields primarily the 2¢ and 3¢ isomers of methylanthraniloyl-UDPGlc (MUG).

8p research12 01-06-2013 43 4   Download

A search has been initiated for lead inhibitors of the non-structural protein 3 (NS3)-associated NTPase/helicase activities of hepatitis C virus,the related West Nile virus, Japanese encephalitis virus and the human mitochondrial Suv3 enzyme. Random screening of a broad range of unre-lated low-molecular mass compounds,employing both RNA and DNA substrates, revealed that 4,5,6,7-tetra-bromobenzotriazole (TBBT) hitherto known as a potent highly selective inhibitor of protein kinase 2,is a good inhibitor of the helicase,but not NTPase,activity of hepa-titis C virus NTPase/helicase. ...

9p fptmusic 16-04-2013 41 4   Download

Lipopolysaccharide (LPS) from the outer membrane of Gram-negative bac-teria belongs to the most potent activators of the mammalian immune sys-tem. Its lipid moiety, lipid A, the ‘endotoxic principle’ of LPS, carries two negatively charged phosphate groups and six acyl chain residues in a defined asymmetric distribution (corresponding to synthetic compound 506). Tetraacyl lipid A (precursor IVa or synthetic 406), which lacks the two hydroxylated acyl chains, is agonistically completely inactive, but is a strong antagonist to bioactive LPS when administered to the cells before LPS addition. .

14p awards 05-04-2013 28 2   Download

Reliable detection and identification of pathogens in complex biological samples, in the presence of contaminating DNA from a variety of sources, is an important and challenging diagnostic problem for the development of field tests. The problem is compounded by the difficulty of finding a single, unique genomic sequence that is present simultaneously in all genomes of a species of closely related pathogens and absent in the genomes of the host or the organisms that contribute to the sample background. ...

11p dell39 27-03-2013 35 4   Download

Phthiocerol dimycocerosates and related compounds are important mole-cules in the biology of Mycobacterium tuberculosis, playing a key role in the permeability barrier and in pathogenicity. Both phthiocerol dimyco-cerosates, the major compounds, and phthiodiolone dimycocerosates, the minor constituents, are found in the cell envelope ofM. tuberculosis, but their specific roles in the biology of the tubercle bacillus have not been established yet.

13p galaxyss3 19-03-2013 43 4   Download

Although plant non-specific lipid transfer proteins (ns-LTPs) are character-ized by their ability to bind and transfer a broad range of hydrophobic ligands in vitro, their biological functions in vivo remain unclear. Recently, it has been proposed that ns-LTPs may play a key role in plant defense mechanisms, particularly during the induction of systemic acquired resis-tance,

12p vinaphone15 28-02-2013 38 3   Download

Elucidating the origin of substrate and coenzyme specificity has been the focus of much work relating to enzyme engineering. Many enzymes exhibit tight specificity for particular substrates despite a close structural relation-ship to other nonreactive compounds.

10p vinaphone15 25-02-2013 37 3   Download

The charged quaternary ammonium compounds – methyl, ethyl and benzyl viologens – generate reactive oxygen species in photosynthetic cells. Three independent methyl viologen-resistant spontaneous mutants of Synechocys-tis sp. PCC 6803 were identified, in which the conserved R115 residue of the Slr1174 protein was replaced with G115, L115 and C115. The Slr1174 protein of the DUF990 family is related to the permease subunit of an ABC-2-type transporter and its R115 mutation was found to be solely responsible for the observed methyl viologen resistance. ...

11p vinaphone15 25-02-2013 30 2   Download

Phthiocerol and phthiodiolone dimycocerosates (DIMs) and phenolic gly-colipids (PGLs) are complex lipids located at the cell surface ofMycobacte-rium tuberculosis that play a key role in the pathogenicity of tuberculosis. Most of the genes involved in the biosynthesis of these compounds are clustered on a region of the M. tuberculosischromosome, the so-called DIM + PGL locus.

11p mobifone23 21-01-2013 48 4   Download

Explore dioxins and dioxin-like compounds. • Summarize the structural similarities of cogeners of dioxins and furans. • Understand Toxicity Equivalency Factors (TEF) and Toxicity Equivalents (TEQ) for dioxins and related compounds. • Summarize the known processes and toxicological endpoints of dioxin exposure.

11p nguyenvanquan037 07-01-2011 70 9   Download

Inhibition of Protein Synthesis Most of the antibacterial agents that inhibit protein synthesis interact with the bacterial ribosome. The difference between the composition of bacterial and mammalian ribosomes gives these compounds their selectivity. Aminoglycosides Aminoglycosides (gentamicin, kanamycin, tobramycin, streptomycin, neomycin, and amikacin) are a group of structurally related compounds containing three linked hexose sugars. They exert a bactericidal effect by binding irreversibly to the 30S subunit of the bacterial ribosome and blocking initiation of protein synthesis.

5p colgate_colgate 21-12-2010 75 3   Download

Introduction: The chemical warfare agents well known count only about 30 kinds of compounds, such as sarin, soman, tabun, VX, mustard gas, lewisite and others. When unknown toxic substances should be analyzed upon the occurrence of chemical terrorism, much more kinds of poisons and related compounds become the objects of analysis. In the Chemical Weapons Convention (CWC)a, 120 thousand compoundsb, including typical chemical warfare agents, their related compounds, precursors and decomposition products, are being listed to be controlled.

22p bigbaby87 01-09-2010 111 17   Download