Responsible for increasing

The incidence of hypervirulent epidemic Clostridium difficile has increased around the world and now in Australia. Assays that are capable of rapidly identifying these strains would enable earlier diagnosis and timely infection control response. The aims of the first part of the study were to validate and develop a molecular technique for the rapid diagnosis of toxigenic C.

134p runthenight07 01-03-2023 9 3   Download

Adopting a triangulated approach, this thesis consists of three separate but related qualitative studies, the collective objectives of which are to (i) gauge current levels of concern of Australian public universities with rapid intensification of the higher education sector globally; (ii) evaluate strategies developed by universities in response to increasing competition; and (iii) develop a conceptual framework to guide competitive behaviour of universities.

291p runthenight04 02-02-2023 9 1   Download

Whilst the level of CQ and the factors that influence CQ have been investigated among business students, it has not been applied to the academics responsible for their education. In the context of CQ, there is a lack of knowledge regarding the capacity or preparedness of university academics to deal with the increasing phenomenon of multiculturalism in the classroom. This research addressed this gap through an examination of the level of CQ exhibited by Australian accounting academics.

305p runthenight04 02-02-2023 6 3   Download

Enterprise Resource Planning (ERP) system is one of the most popular forms of IT for businesses at present. Deriving from efforts to rationalize lead times and possession stock costs, the 80’s manufacturing resource planning (MRP II) is developed into ERP system considered as the standard that integrates business processes throughout the organization, which in turn enhances operational efficiency (Akkermans, Bogerd, Yücesan, & Van Wassenhove, 2003; Davenport, 1998). Callaway (1999) states that the ERP system promises to achieve benefits in both tangible (e.g.

270p kequaidan6 15-07-2020 19 2   Download

Deproteinated cheese whey was used for biomass production of probiotic strain Lactobacillus helveticus MTCC 5463 in a biofermenter. Optimization of growth parameters such as temperature, pH and time of incubation as well as nutrient supplementation of cheese whey was carried out using response surface methodology (RSM). Cheese whey supplemented with 0.95% yeast extract and 0.95% proteose peptone, inoculated with 6% (v/v) active culture of L. helveticus MTCC 5463 and fermented for 24 h at optimized temperature of 40ºC and pH 6.25 yielded 3.25 g/L dry cell biomass and 14.

14p chauchaungayxua6 26-06-2020 26 3   Download

Regulators of G protein signaling (RGS) proteins modulate G protein-coupled receptor (GPCR) signaling networks by terminating signals produced by active Gα subunits. RGS17, a member of the RZ subfamily of RGS proteins, is typically only expressed in appreciable amounts in the human central nervous system, but previous works have shown that RGS17 expression is selectively upregulated in a number of malignancies, including lung, breast, prostate, and hepatocellular carcinoma.

10p caothientrangnguyen 09-05-2020 13 1   Download

Duodenase is a 29-kDa serine endopeptidase that displays selective trypsin- and chymotrypsin-like substrate specificity. This enzyme has been localized to epitheliocytes of Brunner’s glands, and as described here, to mast cells within the intestinal mucosa and lungworm-infected lung, implying an important additional role in inflammation and tissue remodelling. In primary cultures of pulmonary artery fibroblasts, duodenase induced a concentration-dependent increase in [3H]thymidine incorporation with a maximal effect observed at 30 nM.

10p research12 01-06-2013 53 3   Download

Obesity is a central feature of the metabolic syndrome and is associated with increased risk for insulin resistance and type II diabetes. Here, we investigated the contribution of human apoliprotein E3 and mouse apoli-protein E to the development of diet-induced obesity in response to western-type diet. Our data show that apolipoprotein E contributes to the development of obesity and other related metabolic disorders, and that human apolipoprotein E3 is more potent than mouse apolipoprotein E in promoting obesity in response to western-type diet. ...

14p research12 29-04-2013 46 3   Download

Mistletoe extracts have immunomodulatory activity. We show that nontoxic concentrations ofViscumalbumextracts increase natural killer (NK) cell-mediated killing of tumor cells but spare nontarget cells from NK lysis. The com-pounds responsible for this bioactivity were isolated from mistletoe and characterized. They have low molecular mass and are thermostable and protease-resistant.

10p research12 29-04-2013 31 4   Download

Patients with diabetes mellitus suffer from an increased incidence of complications including cardiovascular disease and cataracts; the mechanisms responsible for this are not fully understood. One characteristic of such complications is an accumulation of advanced glycation end-products formed by the adduction of glucose or species derived from glucose, such as low-molecular mass aldehydes, to proteins.

11p fptmusic 16-04-2013 31 3   Download

The Goodpasture antigen-binding protein, GPBP, is a serine⁄threonine kinase whose relative expression increases in autoimmune processes. Tumor necrosis factor (TNF) is a pro-inflammatory cytokine implicated in auto-immune pathogenesis. Here we show that COL4A3BP, the gene encoding GPBP, maps head-to-head withPOLK, the gene encoding for DNA polymerase kappa (polj), and shares with it a 140-bp promoter containing a Sp1 site, a TATA-like element, and a nuclear factor kappa B (NFjB)-like site

15p fptmusic 12-04-2013 36 3   Download

Rat hearts were perfused for 1 h with 5 mMglucose with or without palmitate or oleate at concentrations characteristic of the fasting state. The inclusion of fatty acids resulted in increased activities of the a-1 or thea-2 isoforms of AMP-activated protein kinase (AMPK), increased phosphoryla-tion of acetyl-CoA carboxylase and a decrease in the tissue content of malonyl-CoA. Activation of AMPK was not accompanied by any changes in the tissue contents of ATP, ADP, AMP, phosphocreatine or creatine. ...

10p dell39 03-04-2013 38 3   Download

Adecrease in the level ofO-acetylatedsialicacidsobserved in colorectal carcinoma may lead to an increase in the expres-sion of sialyl Lewis X , a tumor-associated antigen, which is related toprogressionof colorectal cancer tometastasis. The underlyingmechanism for this reduction is, however, not fully understood. Two enzymes are thought to be primarily responsible for the turnover of O-acetyl ester groups on sialic acids; sialate-O-acetyltransferase (OAT) and sialate-O-acetylesterase (OAE).

10p dell39 03-04-2013 64 5   Download

Fluorescent probe rhodamine was appended to 5¢ OH-ribose of cobalamin (Cbl). The prepared conjugate, CBC, bound to the transporting proteins, intrinsic factor (IF) and transcobalamin (TC), responsible for the uptake of Cbl in an organism. Pronounced increase in fluorescence upon CBC attach-ment facilitated detailed kinetic analysis of Cbl binding.

12p inspiron33 23-03-2013 33 3   Download

Multisite protein phosphorylation is a common regulatory mechanism in cell signaling, and dramatically increases the possibilities for protein– protein interactions, conformational regulation, and phosphorylation path-ways. However, there is at present no comprehensive picture of how these factors shape the response of a protein’s phosphorylation state to changes in kinase and phosphatase activities.

16p galaxyss3 21-03-2013 41 4   Download

Lipopolysaccharide is a major constituent of the outer membrane of Gram-negative bacteria. It activates monocytes and macrophages to produce cytokines such as tumor necrosis factor-aand interleukins IL-1b and IL-6. These cytokines appear to be responsible for the neurotoxicity observed in peripheral nervous system inflammatory disease.

11p galaxyss3 07-03-2013 35 4   Download

Extracellular signal-regulated kinases (ERKs) have been shown to be acti-vated by opioids and functionally linked to addiction. Morphine-associated changes in ERK activity seem to be the characteristic features of opioid action. In this study, we observed a rapid and severe increase in ERK1⁄2 activity after a 5 min morphine treatment of HEK-MOR cells (transfected with the ratl-opioid receptor MOR1) expressing l-opioid receptor.

14p galaxyss3 07-03-2013 41 5   Download

The paper by S. Boronatet al. [1] contains errors on page 3331. The corrected sentence and corrected Figure 6 appear below: By contrast, the rainbow trout liver (RTL) cell line showed an EC50 for BNF of 6.1 ± 3.7 nm. These values increased to 53.4 ± 31.2 nmwhen the dose–response curve was performed in the presence of 200lmcarbaryl, indicating an antagonistic effect in these cells similar to the one observed for the yeast YCM-RYA system (Fig. 6; compare with Fig. 3).

1p media19 04-03-2013 29 1   Download

Increasing Quality and Equity in Education: The Case of Chile The actual and counterfactual distributions of school averages are nearly identical. If the counterfactual reflects a substantial increase in sorting on school effectiveness, it must be that effectiveness is responsible for a very small share of the across-school variation in SAT scores.

93p mualan_mualan 25-02-2013 49 7   Download

A common physiological response of organisms to environmental stresses is the increase in expression of heat shock proteins (Hsps). In insects, this process has been widely examined for heat stress, but the response to cold stress has been far less studied.

16p mobifone23 18-01-2013 30 4   Download