Results of drug use

This study revealed that the major contributing descriptors of 2D QSAR studies are DeltaEpsilonB and DeltaPsiA and 3D QSAR model proves the steric as well as electrostatic effects determine the binding affinity for the drug development. The results of the current computational studies are useful for further designing novel chemical entities of anti-microbial agent.

19p dianmotminh02 03-05-2024 5 2   Download

Penile cancer is a rare disease in demand for new therapeutic options. Frequently used combination chemotherapy with 5 fluorouracil (5-FU) and cisplatin (CDDP) in patients with metastatic penile cancer mostly results in the development of acquired drug resistance.

14p vileonardodavinci 23-12-2023 3 2   Download

Tanacetum parthenium (feverfew) is a member of the daisy family; it is used to prevent and treat migraine and rheumatoid arthritis. It has a long history of use as a traditional and folk medicine in Chinese, Greek, Indian and Arabic medicine, having been used for hundreds of years. The term feverfew comes from the Latin word febrifugia and means fever reducer.

4p viintuit 26-09-2023 1 0   Download

The study was carried out by retrospective descriptive method with the list of drugs used at the hospital in 2021 including 237 drugs. Results: Class A drugs accounted for 20.25% of the total number of drugs, accounting for 80% of the use value; class B drugs accounted for 21.52% in quantity and 14.94% in use value; class C drugs accounted for 58.23% in quantity and 5.06% in use value. In class A, the class of traditional medicine preparations accounts for 18.75% in quantity and 21.56% in use value.

9p nhanchienthien 25-07-2023 5 2   Download

Part 1 of ebook "Antimicrobial therapy in veterinary medicine (Fifth edition)" presents the following content: general principles of antimicrobial therapy; classes of antimicrobial agents; antimicrobial susceptibility testing methods and interpretation of results; principles of antimicrobial drug selection and use; other beta-lactam antibiotics - beta-lactamase inhibitors, carbapenems, and monobactams;...

358p dieptieuung 14-07-2023 2 1   Download

Antibiotics administered incorrectly may result in detrimental consequences, such as prolonging treatment duration, causing adverse effects, or even increasing mortality. The research aimed to examine the characteristics of the antibiotics list utilized at PDHC in 2019.

7p viwarmachine 03-07-2023 3 2   Download

To estimate the national cost of ADEs resulting from inappropriate medication-related alert overrides in the U.S. inpatient setting. Materials and Methods: We used three different regression models (Basic, Model 1, Model 2) with model inputs taken from the medical literature. A random sample of 40 990 adult inpatients at the Brigham and Women’s Hospital (BWH) in Boston with a total of 1 639 294 medication orders was taken.

6p visteverogers 24-06-2023 3 2   Download

Estimate the expenditure of computer-related worktime resulting from the use of clinical decision support systems (CDSS) to prevent adverse drug reactions (ADR) among patients undergoing chronic pain therapy and compare the employed check systems with respect to performance and practicability.

9p viisaacnewton 25-04-2022 17 2   Download

Ketamine is a commonly used clinical anesthetic and a popular recreational drug. However, with the exception of studies about the nervous system, studies about the effect of early ketamine exposure on embryos are rare. Xenopus laevis is a commonly used vertebrate model for assessing teratogenicity.

8p viisaacnewton 25-04-2022 5 1   Download

The use of potentially inappropriate medication (PIM) in population of older adults may result in adverse drug events (ADE) already after short term exposure, especially when it is prescribed to patients with chronic kidney disease (CKD). In order to limit ADE in the treatment of older adults PIM lists have been constructed as a source of information for healthcare professionals.

11p viisaacnewton 25-04-2022 13 5   Download

Benzodiazepines (BZDs) and Z-drugs have high potential for developing frequent adverse drug events in older adults (e.g., psychomotor sedation, drug-related dementia, deliria, drug dependence, etc.). Knowledge of the prevalence and patterns of the use of BZDs/Z-drugs in vulnerable older patients is important in order to prevent and reduce the burden caused by their drug-related complications.

16p viisaacnewton 25-04-2022 12 4   Download

Intravascular fluid shifts, mechanical ventilation and inhalational anesthetic drugs may contribute to intraoperative lung injury. This prospective observational study measured the changes in respiratory impedance resulting from inhalational anesthesia and mechanical ventilation in adults undergoing transurethral resection of bladder tumors.

8p viottohahn 30-03-2022 11 1   Download

Modafinil is a drug used in the treatment of narcolepsy, approved by the FDA in 1998. In previous studies, modafinil was easily synthesized through three stages, in the Bunte salt medium, the overall yield of 74,56 %. The quality of the modafinil was evaluated following USP 41. The results have shown that the synthesized modafinil satisfied quality requirements in pharmacopoeia.

6p vikissinger 03-03-2022 11 1   Download

In humans, the drug metabolizing enzyme CYP2D6 is highly polymorphic resulting in substantial differences in the metabolism of drugs including anti-arrhythmics, neuroleptics, and opioids. The objective of this study was to phenotype a population of 100 horses from five different breeds and assess differences in the metabolic activity of the equine CYP2D6 homolog using codeine as a probe drug.

11p vidarwin 23-02-2022 10 1   Download

In the study, antibacterial film synthesis was aimed using sol-gel technique from POSS structure with various functional groups. For this purpose, antibacterial properties have been acquired by metronidazole to the films to be synthesized. The films obtained were coated on glass surface samples by dip coating method. Antibacterial activities of surface coated glass samples were observed in E.coli and S. aureus bacteria. Metronidazole release studies in the film samples were followed by UV spectrophotometer. It was observed that drug release reached 68.90% at the end of the 24th h.

12p langthannam 29-12-2021 14 0   Download

This combination of paclitaxel and curcumin gave a higher efficiency of both drugs in cytotoxicity, induced apoptosis, and effect on cell cycles of KPL4 cell line in comparison with the use of paclitaxel or curcumin alone or even a normal mixture of these two compounds. Furthermore, PTX-Cur/PLA-TPGS nanoparticles exhibited a powerful ability in preventing MCF7 spheroids growth. Interestingly, curcumin also functioned as both a drug and a label. Based on the autofluorescence of curcumin, the absorption of PTX-Cur/PLA-TPGS nanoparticles into MCF7 spheroids could be followed and calculated.

10p guitaracoustic02 08-12-2021 11 1   Download

Novel 1-substituted 3-(p-isopropylphenyl)-5-phenylformazans (3a–g) were synthesized and characterized by elemental analysis, 1H NMR, and FT-IR techniques and UV-visible spectroscopy. Antiproliferative activities of 3a–g against HeLa and C6 cells were determined using the BrdU cell proliferation ELISA assay. 5-Florouracil was used as the positive control. The effects of substituents (–H, –CH3, and –I) and their positions (ortho, meta, and para) on the antiproliferative activities were evaluated.

9p tudichquannguyet 29-11-2021 8 1   Download

In this research, a new series of (E) -3-(4-substitutedphenyl)-1-(4’-morpholinophenyl)prop-2-en-1-one derivatives 1–7 was synthesized, aiming to develop effective antiproliferative agents. The antiproliferative activities of compounds 1–7 were examined against HeLa and C6 cell lines at eight different concentrations using the BrdU ELISA assay. The activity results were compared with reference anticancer drug 5-fluorouracil (5-FU). Compound 1 had almost the same antiproliferative activity as 5-FU.

19p tudichquannguyet 29-11-2021 6 0   Download

The significant development in the construction of microscale cell culture platforms and the interest in bioanalytical analysis have recently resulted in the emergence of a new concept of ‘organ-on-a-chip’ systems. Organon-a-chip is a new three-dimensional (3D) in vitro microfabricated unit that contains a multichannel microfluidic cell culture. Even if many informative and useful data are obtained from animal models and in vitro assays, they are still limited for extrapolation to human systems during drug design and development.

24p tudichquannguyet 29-11-2021 6 1   Download

Liquid–liquid extraction of Au(III) from aqueous sodium malonate medium using 2-octylaminopyridine (2-OAP) as an extractant in xylene was achieved. The current work explored the influence of several experimental parameters such as pH, weak acid concentration, extractant concentration, equilibrium time, stripping agents, and aqueous:organic volume ratio on the extraction of Au(III). The experimental results showed that the Au(III) was quantitatively extracted to about 99.5% by 0.05 M 2-OAP in 0.05 M malonate at 5.0 pH.

22p tudichquannguyet 29-11-2021 5 2   Download