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Ring close metathesis
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We have developed a simple synthetic methodology for bis-spirocycles and spiroindole derivatives starting with a commercially available 6-bromo-2-tetralone. Here, we have used Fischer indolization, ring-closing metathesis, and Suzuki–Miyaura cross-coupling as key steps to assemble a variety of spirocyclic frameworks. The methodology developed here is simple and it may be useful to prepare various spirocycles containing indole moiety.
9p
langthannam
29-12-2021
6
0
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The one-pot synthesis of novel 1,4-disubstituted 1,2,3-triazoles from isoquinoline-substituted homopropargyl alcohol backbone is described (42%–88% yields). A ring closing metathesis reaction and an intramolecular Pauson–Khand reaction of enyne system derived from a homopropargyl alcohol backbone to afford the corresponding isoquinolinesubstituted dihydropyran and cyclopentenone-pyran, respectively, are also described (54% and 78% yields).
12p
langthannam
29-12-2021
9
0
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The MS analysis of these alkene substrates helps us understand their structures. In this paper, the analysis is focused on not only on molecular weights but also on primary fragmentations based on effects such as resonance and ortho effects to obtain more data for these kinds of compounds.
6p
tamynhan5
10-12-2020
6
1
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