RNA polymerase III
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The human genome is hierarchically organized into local and long-range structures that help shape cell-type-specific transcription patterns. Transfer RNA (tRNA) genes (tDNAs), which are transcribed by RNA polymerase III (RNAPIII) and encode RNA molecules responsible for translation, are dispersed throughout the genome and, in many cases, linearly organized into genomic clusters with other tDNAs.
18p vialfrednobel 29-01-2022 6 0 Download
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Single-guide RNA (sgRNA) is one of the two key components of the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 genome-editing system. The current commonly used sgRNA structure has a shortened duplex compared with the native bacterial CRISPR RNA (crRNA)–transactivating crRNA (tracrRNA) duplex and contains a continuous sequence of thymines, which is the pause signal for RNA polymerase III and thus could potentially reduce transcription efficiency.
10p viaristotle 29-01-2022 12 0 Download
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The relationship between transcription and the 3D chromatin structure is debated. Multiple studies have shown that transcription affects global Cohesin binding and 3D genome structures. However, several other studies have indicated that inhibited transcription does not alter chromatin conformations.
28p viarchimedes 26-01-2022 11 0 Download
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BRF2 is a transcription factor required for synthesis of a small group of non-coding RNAs by RNA polymerase III. Overexpression of BRF2 can transform human mammary epithelial cells. In both breast and lung cancers, the BRF2 gene is amplified and overexpressed and may serve as an oncogenic driver.
11p vimoscow2711 29-08-2020 6 0 Download
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PLATZ proteins are a novel class of plant-specific zinc-dependent DNA-binding proteins that are classified as transcription factors (TFs). However, their common biochemical features and functions are poorly understood.
12p vishikamaru2711 29-04-2020 12 0 Download
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Type III Interferons also known as Interferon lambdas (IFNs/IFNLs) constitute a recently described IFN with antiviral activities by signaling through a unique receptor complex composed of IFNs receptor 1 (IFNR1) and interleukin-10 receptor 2 (IL10R2). It also found to have more of immune modulatory activities in addition to antiviral activities. In the present study, the construct pcDNA-bovine IFNλ3 was administered intramuscularly to mice. The mice were sacrificed on 7th and 14th day to collect the different organs/tissues.
5p caygaocaolon3 09-03-2020 10 1 Download
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3 được mở rộng bởi DNA pol III. 6. Nhân rộng trên các sợi tụt hậu là không liên tục bởi vì polymerase chỉ có thể sao chép các khu vực sợi đơn có sẵn tại ngã ba và chỉ trong 5 '3' hướng. a. Một mồi RNA ngắn là lần đầu tiên được tổng hợp gần nhất kết thúc 3 của ngã ba bởi primase, mà thực sự là một DNA hướng RNA polymerase
24p kimku12 26-10-2011 59 2 Download
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Atypical clinical presentation of a subset of patients with anti-RNA polymerase III - nonscleroderma cases associated with dominant RNA polymerase I reactivity and nucleolar staining...
7p thulanh16 22-10-2011 62 4 Download