Safety analysis
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Patients with rheumatologic preexisting autoimmune disease (PAD) have not been enrolled in clinical trials of immune checkpoint inhibitors (ICIs). Therefore, the risks and benefits of ICI therapy in such patients are unclear. Herein, we investigated the safety and efficacy of ICIs in rheumatologic PAD patients through a meta-analysis.
14p vishanshan 27-06-2024 3 1 Download
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In recent years, breast cancer (BC) incidence and mortality have been the highest in females. Menopause-like syndrome (MLS), arising from hypoestrogenism caused by endocrine therapy, signifcantly afects the quality of life for females. Traditional Chinese Medicine (TCM) has advantages in ameliorating MLS, but the efficacy of TCM in patients with BC has not been systematically evaluated.
19p vishanshan 27-06-2024 1 1 Download
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Part 2 of ebook "Proceedings of the 21st International symposium on advancement of construction management and real estate" provides readers with contents including: examining critical factors affecting knowledge transfer in public-private partnership (PPP) projects; explication of challenges with acceptance of marketing functions in the management of construction business enterprise; factors influencing safety training transfer on construction sites; factors influencing the construction time and cost overrun in projects; feasibility analysis of using construction and demolition waste in se...
789p mothoiphong 28-06-2024 1 1 Download
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Part 1 of ebook "Reinforced concrete designer's handbook (Tenth edition)" provides readers with contents including: introduction; safety factors, loads and pressures; structural analysis; materials and stresses; resistance of structural members; structures and foundations; electronic computational aids: an introduction; partial safety factors; loads; pressures due to retained materials; cantilevers and beams of one span; continuous beams; influence lines for continuous beams;...
217p mothoiphong 28-06-2024 1 1 Download
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Part 1 of ebook "Reynolds’s reinforced concrete designers handbook (Eleventh edition)" provides readers with contents including: general information; design criteria, safety factors and loads; structural analysis; design of structural members; buildings, bridges and containment structures; loads, materials and structures; pressures due to retained materials; cantilevers and single-span beams;...
249p mothoiphong 28-06-2024 1 1 Download
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Medical narcotics must be administered under medical supervision because of their potential for misuse and abuse, leading to more dangerous and addictive substances. The control of medical narcotics requires close monitoring to ensure that they remain safe and effective. This study proposes a methodology that can effectively identify the overprescription of medical narcotics in hospitals and patients.
12p vishanshan 27-06-2024 3 1 Download
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Among the various methods used, administrative data collected for claims and billing purposes, such as diagnosis codes and present-on-admission (POA) indicators, can easily be employed to assess patient safety status. However, it is crucial that administrative data be accurate to generate valid estimates of adverse event (AE) occurrence.
7p vishanshan 27-06-2024 1 1 Download
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Immunotherapy or apatinib alone has been used as third-line adjuvant therapy for advanced or metastatic gastric/gastroesophageal junction (G/GEJ) tumors, but the efficacy of combining them with each other for the treatment of patients with advanced or metastatic G/GEJ is unknown; therefore, we further evaluated the efficacy and safety of immunotherapy combined with apatinib in patients with advanced or metastatic G/GEJ.
18p vishanshan 27-06-2024 1 1 Download
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Several studies have been conducted with the 1.0 version of the Hospital Survey on Patient Safety Culture (HSOPSC) in Norway and globally. This study aims to 1) assess the psychometrics of the Norwegian version (N-HSOPSC 2.0), and 2) assess the criterion validity of the N-HSOPSC 2.0, adding two more outcomes, namely ‘pleasure of work’ and‘turnover intention’
10p vishanshan 27-06-2024 2 1 Download
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The addition of pertuzumab (P) to trastuzumab (H) and standard chemotherapy (CT) as neoadjuvant treatment (NaT) for patients with HER2+breast cancer (BC), has shown to increase the pathological complete response (pCR) rate, without main safety concerns. The aim of NeoPowER trial is to evaluate safety and efficacy of P+H+CT in a real–world population.
18p vikoch 27-06-2024 1 1 Download
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It is unclear whether hepatectomy, which ranges in invasiveness from partial to major hepatectomy, is safe and feasible for older adult patients. Therefore, we compared its postoperative complications and long-term outcomes between younger and older adult patients.
13p vikoch 27-06-2024 1 1 Download
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Poly (ADP- ribose) polymerase inhibitors (PARPi) has been increasingly adopted for metastatic castration-resistance prostate cancer (mCRPC) patients with homologous recombination repair deficiency (HRD). However, it is unclear which PARPi is optimal in mCRPC patients with HRD in 2nd -line setting.
10p vikoch 27-06-2024 1 1 Download
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The benefit of adding Zolbetuximab to the treatment in patients with Claudin-18 isoform 2 (CLDN18.2)- positive, human epidermal growth factor receptor 2-negative, locally advanced unresectable or metastatic gastric or gastro-oesophageal junction adenocarcinoma (GC/GEJ) is not yet fully elucidated.
11p vikoch 27-06-2024 1 1 Download
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To compare the efficacy, safety and effects on quality of life of different ALK-inhibitors for global and Asian patients with advanced ALK-positive non-small-cell lung cancer (NSCLC).
15p vikoch 27-06-2024 1 1 Download
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In this meta-analysis, we conducted a comparative analysis of the safety and efficacy of hypofractionated and conventional fractionated radiotherapy in individuals who had undergone surgery for breast cancer.
18p vikoch 27-06-2024 1 1 Download
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Recent advances in the management of pancreatic neuroendocrine tumors (pNETs) highlight the potential benefits of temozolomide, an alkylating agent, for these patients. In this meta-analysis, we aimed to assess the outcome of temozolomide, alone or in combination with other anticancer medications in patients with advanced pNET.
15p vikoch 27-06-2024 1 1 Download
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The efficacy and safety of subxiphoid thoracoscopic thymectomy (SVATS) for early thymoma are unknown. The purposes of this meta-analysis were to evaluate the effectiveness and safety of SVATS for early thymoma, to compare it with unilateral intercostal approach video thoracoscopic surgery (IVATS) thymectomy, and to investigate the clinical efficacy of modified subxiphoid thoracoscopic thymectomy (MSVATS) for early anterior mediastinal thymoma.
13p vikoch 27-06-2024 3 1 Download
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The research aims to propose solutions for mergers between Vietnamese securities companies to improve the financial capacity of securities companies currently operating on the Vietnam Stock Exchange - VNX (HNX, HoSE and Upcom exchanges). Through research samples collected from 27 Vietnamese securities companies in the period from 2014 to 2021, secondary data are audited financial statements and financial safety reports. By using the quantitative research method of principal component analysis PCA (Principal Component Analysis) and K-means (cluster) analysis on SPSS 20 software.
8p leminhvu111 07-06-2024 1 0 Download
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Ebook Food spoilage microorganisms: Ecology and control focuses on the occurrence, outbreak, consequences, control, and evaluation of spoilage microorganisms in food, providing the necessary basic knowledge of food spoilage ecology and control so as to ensure food safety, especially in developing countries where food hygiene in storage requires special care.
204p vimeyers 29-05-2024 2 2 Download
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This is the general subject of Software Quality Engineering, which is organized into three major topics: Software testing as a primary means to ensure software quality; Other alternatives for quality assurance (QA), including defect prevention, process improvement, inspection, formal verification, fault tolerance, safety assurance, and damage control; Measurement and analysis to close the feedback loop for quality assessment and quantifiable improvement.
441p zizaybay1103 29-05-2024 1 1 Download