Second best base call

Deep-sequencing allows for an in-depth characterization of sequence variation in complex populations. However, technology associated errors may impede a powerful assessment of low-frequency mutations. Fortunately, base calls are complemented with quality scores which are derived from a quadruplet of intensities, one channel for each nucleotide type for Illumina sequencing.

11p vikentucky2711 26-11-2020 11 1   Download

The search space of Phrase-Based Statistical Machine Translation (PBSMT) systems can be represented under the form of a directed acyclic graph (lattice). The quality of this search space can thus be evaluated by computing the best achievable hypothesis in the lattice, the so-called oracle hypothesis. For common SMT metrics, this problem is however NP-hard and can only be solved using heuristics.

10p bunthai_1 06-05-2013 60 4   Download