Secondary cancers

Cervical cancer is the fourth most common cancer in women, with an estimated 342,000 deaths worldwide in 2020. Current standard of care in the UK for locally advanced cervical cancer is concurrent chemoradiotherapy with weekly cisplatin, yet 5-year overall survival rates are only 65% with a distant relapse rate of 50%.

10p vishanshan 27-06-2024 1 1   Download

The aim of this study is to investigate if initiation of beta-blocker therapy reduces the prevalence and severity of intrusive thoughts (co-primary endpoints) and the prevalence of anxiety, depressed mood, and low quality of life (secondary endpoints) in cancer survivors.

8p vishanshan 27-06-2024 1 1   Download

Tumor genomic profiling (TGP) identifies targets for precision cancer treatments, but also secondary hereditary risks. Oncologists are poorly trained to communicate the results of TGP, especially among patients with lower health literacy, poorer genetics knowledge, and higher mistrust.

11p vishanshan 27-06-2024 1 1   Download

Multiple studies have indicated that patients with high body mass index (BMI) may have favourable survival outcomes following treatment with an immune checkpoint inhibitor (ICI). However, this evidence is limited by several factors, notably the minimal evidence from randomised controlled trials (RCTs), the use of categorised BMI with inconsistent cut point definitions, and minimal investigation of contemporary combination ICI therapy.

8p vishanshan 27-06-2024 1 1   Download

Existing knowledge on healthcare use and costs in the last months of life is often limited to one patient group (i.e., cancer patients) and one level of healthcare (i.e., secondary care). Consequently, decision-makers lack knowledge in order to make informed decisions about the allocation of healthcare resources for all patients.

13p vishanshan 27-06-2024 1 1   Download

To compare the diagnostic performance of the Node-RADS scoring system and lymph node (LN) size in preoperative LN assessment for rectal cancer (RC), and to investigate whether the selection of size as the primary criterion whereas morphology as the secondary criterion for LNs can be considered the preferred method for clinical assessment.

13p vikoch 27-06-2024 1 1   Download

To assess the long-term association between organised colorectal cancer (CRC) screening strategies and CRC-relate mortality. Methods We systematically reviewed studies on organised CRC screening through PubMed, Ovid Medline, Embase and Cochrane from the inception.

8p vikoch 27-06-2024 3 1   Download

Phytochemical study of Knema pachycarpa leaves led to the isolation of ten compounds. Their chemical structures were determined as (7''R, 8''R)-hydnocarpin D, (7''R, 8''R)-hydnocarpin, sinaicitin, (-)-globulol, β-caryolanol, phytol, biochanin A, chrysoeriol, tanoside II and astragalin using NMR and MS spectral data. Among the isolates, (7''R, 8''R)-hydnocarpin showed good cytotoxic activity against KB, HepG-2, Lu and MCF-7 cancer cell lines with IC50 values from 13.99±0.62 ug/mL to 30.65±1.44 ug/mL.

6p dianmotminh02 03-05-2024 1 1   Download

Prior research has established that the prevalence of pathogenic/likely pathogenic (P/LP) variants across all of the American College of Medical Genetics (ACMG) Secondary Findings (SF) genes is approximately 0.8–5%. We investigated the prevalence of P/LP variants in the 24 ACMG SF v2.0 cancer genes in a family-based cancer research cohort (n = 1173) and in cancer-free ethnicity-matched controls (n = 982).

9p vibransone 28-03-2024 3 2   Download

The development of secondary resistance (SR) in metastatic colorectal cancer (mCRC) treated with anti-epidermal growth factor receptor (anti-EGFR) antibodies is not fully understood at the molecular level. Here we tested in vivo selection of anti-EGFR SR tumors in CRC patient-derived xenograft (PDX) models as a strategy for a molecular dissection of SR mechanisms.

25p vibransone 28-03-2024 3 2   Download

Advances in the treatment of biliary tract cancer have been made possible through gains in genomic and epigenetic tumor understanding. The use of fibroblast growth factor receptor inhibitor has enabled significant clinical improvement in a specific group of patients with intrahepatic cholangiocarcinoma, some of whom with very durable responses.

7p vitiki 30-01-2024 7 2   Download

Cerebral arterial air embolism is often associated with an invasive iatrogenic etiology and a high rate of convulsive seizures. There are only a few descriptions of electroencephalogram findings in convulsive seizures due to cerebral arterial air embolism of noniatrogenic etiology.

6p vitiki 30-01-2024 3 2   Download

Hypoproliferative anemia is a frequently encountered adverse event in cancer patients receiving immune checkpoint inhibitors (ICI). Secondary pure red cell aplasia (PRCA) is a rare but recognized immune-related adverse event. With the burgeoning use of ICIs, the association of secondary PRCA with an underlying lymphoproliferative disorder is often overlooked.

5p vitiki 30-01-2024 3 2   Download

Acrometastasis is an uncommon finding in non-small cell lung cancer and is usually a sign of multi-metastatic disease. Few case reports have suggested solitary digital metastasis as the single secondary lesion of oligo-metastatic non-small cell lung cancer.

4p vitiki 30-01-2024 3 2   Download

Several novel of polymethoxyquercetin Mannich base derivatives (2-7) were synthesized through O-methylation and based on Mannich reaction with various secondary amines and formaldehyde, starting from abundant and inexpensive natural sources quercetin.

8p vimarillynhewson 02-01-2024 1 1   Download

Part 3 book "Veterinary immunology" includes content: Organ graft rejection and pregnancy; cancer immunology and immunotherapy; autoimmunity; organ specific autoimmune diseases; immune mediated inflammatory diseases; primary immunodeficiencies; secondary immunological defects; drugs and other agents that affect the immune system; immunodiagnostic techniques; evolution of the immune system.

625p muasambanhan03 02-01-2024 3 2   Download

The aim of the study is to investigate the clinical features and surgical outcomes of ureteral reconstruction during primary, interval and secondary cytoreductive surgery for ovarian cancer.

9p vileonardodavinci 23-12-2023 2 2   Download

Nutritional support, including nutritional counseling and oral nutritional supplements (ONS), has been recommended as a first-line strategy in patients with non-small cell lung cancer (NSCLC). Evidence on the efficacy of immunonutrition during immunotherapy in these patients is positive, but still limited some secondary endpoints, such as treatment toxicity and tolerance.

10p vileonardodavinci 23-12-2023 4 2   Download

This study aimed to understand and compare cancer incidence and risk in three patient groups: recipients of solid organ transplant (SOT) or hematopoietic stem cell transplant (HSCT); diagnosis of primary or secondary immunodeficiency disorder (PID/SID); and recipients of tumor necrosis factor inhibitor (TNF-i) therapy.

9p vileonardodavinci 23-12-2023 4 2   Download

The objective of this study was to investigate the tolerance of capecitabine, an example of oral chemotherapy, among older adults with cancer and explore factors associated with capecitabine-related side effects and treatment changes, to enhance supportive care.

14p vialfrednobel 23-12-2023 5 4   Download