Senescence

Clear cell renal cell carcinoma (ccRCC) is the prevailing histological subtype of renal cell carcinoma and has unique metabolic reprogramming during its occurrence and development. Cell senescence is one of the newly identified tumor characteristics. However, there is a dearth of methodical and all-encompassing investigations regarding the correlation between the broad-ranging alterations in metabolic processes associated with aging and ccRCC.

23p vishanshan 27-06-2024 2 1   Download

Ebook "p53 Protocols (Second edition)" expert researchers in the field detail many of the methods that address the challenging questions of the p53 field. These methods include the identification of the target genes and binding partners of gain of function p53 mutants, methods to determine stress response, autophagy or senescence induced by p53, cell cycle analysis, analysis of different phases of DNA replication modified by p53, and generation of pluripotent stem cells.

251p dongmelo 27-05-2024 3 2   Download

Breast cancer is the most common malignancy globally, and is considered a major cause of cancer-related death. Tremendous effort is exerted to identify an optimal anticancer drug with limited side effects. The quinoline derivative RIMHS-Qi-23 had a wide-spectrum antiproliferative activity against various types of cancer cells.

12p vialfrednobel 23-12-2023 3 3   Download

Cervical cancer is currently estimated to be the fourth most common cancer among women worldwide and the leading cause of cancer-related deaths in some of the world’s poorest countries. C/EBPβ has tumor suppressor effects because it is necessary for oncogene-induced senescence. However, C/EBPβ also has an oncogenic role.

13p vischultz 20-10-2023 2 1   Download

Recent studies have shown that the high incidence and low cure rate of hepatocellular carcinoma (HCC) have not improved signifcantly. Surgery and liver transplantation are the mainstays of prolonging the survival of HCC patients. However, the surgical resection rate of HCC patients is very low, and even after radical surgical resection, the recurrence rate at 5 years postoperatively remains high and the prognosis is very poor, so more treatment options are urgently needed.

16p visharma 20-10-2023 3 2   Download

Part 2 book "Principles of animal cell culture" includes content: Gene expression and application of animal cell culture for its studies, organ culture, transfection, cell fusion, selectable marker and antibiotic resistance, hybridoma and monoclonal antibodies, transplantation of cultured cell, differentiation of cells, transgenesis and transgenic animals, apoptosis, necrosis, senescence and quiescence, embryo transfer technology.

158p oursky05 20-09-2023 2 2   Download

Part 2 book "Vertebrate skeletal histology and paleohistology" includes content: Cyclical growth and skeletochronology, nonmammalian synapsids, diversity of bone microstructure in mammals, aging and senescence processes in the skeleton, basic principles and methodologies in measuring bone biomechanics, bone microanatomy and lifestyle in tetrapods.... and other contentes.

401p oursky05 20-09-2023 2 1   Download

Bài viết Khảo sát khả năng của phycocyanin trong bảo vệ da in vitro và in vivo tiến hành đánh giá khả năng của PC trong việc bảo vệ tế bào nguyên bào sợi khỏi tác nhân gây oxi hóa mạnh H2O2 và bảo vệ da khỏi tác hại của tia UV. Kết quả nghiên cứu sẽ là bước đệm để phát triển sản phẩm từ tảo trong lĩnh vực thẩm mỹ.

10p vinebula 02-06-2023 8 3   Download

Melatonin (MT) is considered as a plant growth regulator, has extensive functions and plays a prominent role in ripening and fruit senescence. However, there has been no report regarding the influence of melatonin on biochemical changes of avocado fruit (Persea americana Mill.) during ripening.

10p vicaptainmarvel 21-04-2023 4 2   Download

This study aimed to assess the effects of simulated microgravity (SMG) on senescent human fibroblasts (HFs). The HFs were treated with 150 µM H2O2 in a culture medium for 90 minutes for senescent induction. The senescent HFs were induced SMG for 72 hours by a Gravity simulator, while the control group was treated in the same CO2 incubator.

8p vicaptainmarvel 21-04-2023 5 2   Download

The NAM-B1 gene in wheat has for almost three decades been extensively studied and utilized in breeding programs because of its significant impact on grain protein and mineral content and pleiotropic effects on senescence rate and grain size.

10p vinarcissa 21-03-2023 3 1   Download

The commercialization of mushrooms is critical because they have a short shelf life. For this reason, we investigated the effect of agar-agar and egg white protein on weight loss, polyphenol oxidase and catalase, protein content, total phenolics, total antioxidant capacity, respiration rate, ethylene production and storability of button mushrooms. Our findings suggested that the treatment of edible coating delayed remarkably senescence and maintained the quality of button mushroom.

9p lyhuyenthu 31-01-2023 4 2   Download

WRKY transcription factors (TFs) participate in various physiological processes of plants. Although WRKY genes have been well studied in model plants, knowledge of the functional roles of these genes is still extremely limited in cotton.

14p vihagrid 30-01-2023 7 3   Download

Oxidative stress is closely associated with the initiation and progression of aging. Considerable interest centers in the potential application of natural polysaccharides in oxidative stress alleviation and senescence delay.

11p viginny 30-12-2022 10 3   Download

Functional characterization of non-coding elements in the human genome is a major genomic challenge and the maturation of genome-editing technologies is revolutionizing our ability to achieve this task. Oncogene-induced senescence, a cellular state of irreversible proliferation arrest that is enforced following excessive oncogenic activity, is a major barrier against cancer transformation.

13p vigalileogalilei 27-02-2022 10 1   Download

Histone modification H4K20me3 and its methyltransferase SUV420H2 have been implicated in suppression of tumorigenesis. The underlying mechanism is unclear, although H4K20me3 abundance increases during cellular senescence, a stable proliferation arrest and tumor suppressor process, triggered by diverse molecular cues, including activated oncogenes.

20p viaristotle 29-01-2022 5 0   Download

Cellular senescence is a permanent state of replicative arrest defined by a specific pattern of gene expression. The epigenome in senescent cells is sculptured in order to sustain the new transcriptional requirements, particularly at enhancers and super-enhancers.

25p viarchimedes 26-01-2022 12 0   Download

Cellular senescence, a permanent state of replicative arrest in otherwise proliferating cells, is a hallmark of aging and has been linked to aging-related diseases. Many genes play a role in cellular senescence, yet a comprehensive understanding of its pathways is still lacking.

22p viarchimedes 26-01-2022 9 1   Download

Post transcriptional gene regulation in wheat cultivars caused by boron (B) toxicity has not been reported to date. In this study, two wheat cultivars Bolal-2973 (B-tolerant) and Atay-85 (B-sensitive) were compared with regard to the transcriptional regulation of miR319, miR172 and miR398 and their plausible target genes in order to address differences in their performances under high B levels. The expression levels of Cu/ZnSOD gene were found to be greater in Atay exposed to toxic B compared to Bolal, as verified by stable expression level of miR398.

23p hanthienngao 30-11-2021 12 1   Download

Ethylene is an important phytohormone that regulates several aspects of plant development including those crucial for drought tolerance. The main aim of the present work was to investigate variability in ethylene sensitivity of mungbeans to seed germination, waterlogging, and leaf senescence, and the underlying transcriptional regulation of ethylene biosynthetic/responsive genes. Significant variation was observed for silver-nitrate–mediated germination inhibition and flooding stress tolerance among the mungbean genotypes.

12p tudichquannguyet 29-11-2021 8 1   Download