Septic cardiomyopathy

3,3′-Diindolylmethane (DIM) has been extensively studied as a potential therapeutic drug with free radical scavenging, antioxidant and anti-angiogenic effects. However, whether DIM has similar effects on cardiomyocytes remains unknown.

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Vieillard-Baron Annals of Intensive Care 2011, 1:6 http://www.annalsofintensivecare.com/content/1/1/6 REVIEW Open Access Septic cardiomyopathy Antoine Vieillard-Baron1,2 Abstract Depression of left ventricular (LV) intrinsic contractility is constant in patients with septic shock. Because most parameters of cardiac function are strongly dependent on afterload, especially in this context, the cardiac performance evaluated at the bedside reflects intrinsic contractility, but also the degree of vasoplegia.

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