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Serum metabolites
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Our findings demonstrate the presence of distinct metabolites in the serum of gastric cancer patients compared to healthy individuals. Lysophosphatidic acid, triglycerides, lysine, sphingosine1-phosphate, phosphatidylcholine, oxidized ceramide, and phosphatidylglycerol hold potential as biomarkers for evaluating postoperative efficacy and monitoring recurrence in gastric cancer patients.
12p
vishanshan
27-06-2024
1
1
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This study aims to identify key metabolites and metabolic pathways associated with the multistage progression of epithelial cancer and to explore their predictive value for gastroesophageal cancer (GEC) formation and for the early screening of esophageal squamous cell carcinoma (ESCC).
9p
vileonardodavinci
23-12-2023
7
3
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Tryptophan, an essential amino acid, and its metabolites are involved in many physiological processes including neuronal functions, immune system, and gut homeostasis. Alterations to tryptophan metabolism are associated with various pathologies such as neurologic, psychiatric disorders, inflammatory bowel diseases (IBD),
10p
vironald
15-12-2022
8
2
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Weaning of goat kids immediately after birth and feeding them on bovine or heat-treated caprine colostrum, referred to as snatching, is considered an effective control measure in some infectious diseases. The study was carried out in one-week-old goat kids to gain insight into the profile of lipid metabolites and to investigate the influence of snatching on kids’ metabolism.
9p
vigandhi
23-02-2022
8
1
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Gut microbial compositional and functional variation can affect health and production performance of farm animals. Analysing metabolites in biological samples provides information on the basic mechanisms that affect the well-being and production traits in farm animals.
13p
vidarwin
22-02-2022
16
1
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The gut microbiome is a complex and metabolically active community that directly influences host phenotypes. In this study, we profile gut microbiota using 16S rRNA gene sequencing in 531 well-phenotyped Finnish men from the Metabolic Syndrome In Men (METSIM) study.
14p
vialfrednobel
29-01-2022
17
0
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Four potential biomarkers were found in urine and serum samples to distinguish clear cell renal cell carcinoma (ccRCC) from controls, 4 for the ccRCC with and without metastases, and 6 metabolites to distinguish low and high stages or grades.
10p
lazzaro
30-12-2021
17
1
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Cardiac hypertrophy (CH), leading to cardiac failure is due to chronic metabolic alterations occurring during cellular stress. Besides the already known relationship between oxidative stress and CH, there are implications of reductive stress leading to CH. This study attempted to develop reductive stress-based CH rat model using n-acetyl-L-cysteine (NAC), a glutathione agonist that was compared with typical isoproterenol (ISO) induced CH model.
21p
thiencuuchu
27-11-2021
11
1
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Long-term smoking exposure will increase the risk of esophageal squamous cell carcinoma (ESCC), whereas the mechanism is still unclear. We conducted a cross-sectional study to explore whether serum metabolites mediate the occurrence of ESCC caused by cigarette smoking.
8p
vianrose2711
27-04-2021
8
2
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Recent reports indicate that oxidative stress induced by reactive oxygen species is associated with the pathobiology of neurodegenerative disorders that involve neuronal cell apoptosis. Here we conducted a crosssectional study to evaluate serum levels of oxidative stress in cervical compression myelopathy.
10p
vivermont2711
28-01-2021
10
3
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The prognosis of pancreatic cancer (PC) is one of the poorest among all cancers, due largely to the lack of methods for screening and early detection. New biomarkers for identifying high-risk or early-stage subjects could significantly impact PC mortality.
17p
vijennie2711
29-09-2020
18
1
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Tamoxifen has dramatically reduced the recurrence and mortality rate of estrogen receptor positive breast cancer. However, the efficacy of tamoxifen varies between individuals and 40% of patients will have a recurrence despite adjuvant tamoxifen treatment. Factors that predict tamoxifen efficacy would be helpful for optimizing treatment.
10p
vijennie2711
25-09-2020
13
1
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Tamoxifen, the most frequently used drug for treating estrogen receptor-positive breast cancer, must be converted into active metabolites to exert its therapeutic efficacy, mainly through CYP2D6 enzymes.
12p
viamsterdam
18-09-2020
12
1
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In the current study, we investigated, the possible relationship between vitamin E, selenium, high energy diet supplementation and its effects on serum metabolites. The present study was conducted on a total of 30 animals, 15 were in each group (Control and Treatment).
6p
nguaconbaynhay7
15-08-2020
7
1
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Measuring concentrations of metabolites of estradiol and progesterone in urine, instead of measuring serum concentrations, is common in research and also is used in patient care. The primary aim of this study was to demonstrate that analysis of urine samples dried on filter paper by gas chromatography with tandem mass spectrometry (GC–MS/MS) provides results similar to serum analyzed by radioimmunoassay (RIA).
12p
vijiraiya2711
27-05-2020
11
0
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The experiment was conducted to investigate the effect of antioxidant [vitamin E (vit E)] and trace minerals [selenium (Se), copper (Cu), zinc (Zn)], high energy diet supplementation and its effect on allometric and physio-biochemical parameters in crossbred cows during transition period. For this, advanced pregnant crossbred cows (n = 20) of 2nd to 4th parity and lactation potential of >10 L/day at 28 days prepartum were divided into two groups viz. control (CON) and treatment (TRT) consisting of 10 animals each.
9p
nguaconbaynhay5
16-05-2020
11
1
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This study was conducted to evaluate the impact of age (from birth to three months) on serum metabolites and minerals in crossbred calves. The research was carried out on six apparently healthy crossbred calves (aged 0-3 months) of similar physiological status. Blood samples were collected from the experimental animals on 0, 3, 7, 10, 15, 30, 45, 60, 75 and up to 90 days age of calves.
6p
nguathienthan4
21-04-2020
8
1
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The present study was carried out in the thoroughbred stall housed horses maintained at College of Veterinary Science and Animal Husbandry, Bhubaneswar under hot and humid climatic conditions of Odisha with an objective to determine the effect of exercise on hematological and serum biochemical indices. Blood samples were drawn from jugular veins of the animals in the morning and 30, 240 and 480 minutes after exercise and subsequently assessed for haematological and serum biochemical parameters.
10p
quenchua4
06-04-2020
9
0
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Taxus (yew) is one of the most frequently reported plants causing potentially fatal outcome when taken incidentally or for suicidal reasons. A fast and reliable method of detection of poisonous compounds or their metabolites is critical in life-saving procedures in cases of yew ingestion.
8p
vienzym2711
30-03-2020
17
2
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