Several interactive factors

Ebook "CtBP family proteins" are unique in several aspects. They were the first among proteins containing a metabolic enzyme fold to be implicated in transcriptional regulation. The vertebrate CtBPs exhibit distinct nuclear and cytosolic activities. The crystal struaures of CtBPl and molecular modeling studies have illuminated the molecular basis of its dual activity and the interaction with target peptides.

131p ladongphongthanh1008 22-04-2024 5 2   Download

Age and obesity are dominant risk factors for several common cardiometabolic disorders, and both are known to impair adipose tissue function. However, the underlying cellular and genetic factors linking aging and obesity on adipose tissue function have remained elusive.

24p vicwell 29-02-2024 4 2   Download

As the main isoforms of membranous glucose transporters (GLUT), GLUT1 involves tumorigenesis, metastasis and prognosis in a variety of cancers. However, its role in breast cancer metastasis remains to be elucidated. Here we examined its transcriptional and survival data in patients with breast cancer from several independent databases including the Oncomine, Gene Expression Profling Interactive Analysis, Gene Expression across Normal and Tumor tissue, UALCAN, cBioPortal, Kaplan-Meier Plotter and PROGgeneV2.

15p vileonardodavinci 23-12-2023 4 2   Download

Cancer is a major public health problem with pharmacotherapy being the cornerstone of its management. Cancer patients receive multiple drugs concurrently risking Drug-Drug Interactions (DDIs).

11p vileonardodavinci 23-12-2023 2 2   Download

The malignant behaviors of lung cancers are affected by not only cancer cells but also many kinds of stromal cells in tumor microenvironment (TME), including macrophages. Macrophages have been proven to extensively influence tumor progression through several mechanisms, among which switching of macrophages from proinflammatory phenotypes (M1-like) to anti-inflammatory phenotypes (M2-like) mediated by transcription factors such as nuclear factor κB (NF-κB) is the most crucial event. The regulation of NF-κB has been well studied, however some details remain fuzzy.

18p vileonardodavinci 23-12-2023 3 2   Download

Truck crashes related to brake failure have been an increasing issue for traffic safety in Vietnam recently. Although previous studies have pointed out several variables directly related to this type of crash, there has been no research to further examine influencing factors resulting from other actors representing inside a road transport system and the interactions among them.

14p viberkshire 09-08-2023 5 3   Download

Low vitamin D status has been shown to be a risk factor for several metabolic traits such as obesity, diabetes and cardiovascular disease. The biological actions of 1, 25-dihydroxyvitamin D, are mediated through the vitamin D receptor (VDR), which heterodimerizes with retinoid X receptor, gamma (RXRG).

8p vinarcissa 21-03-2023 6 1   Download

The study examines how Small-Medium-sized Enterprises (SMEs) demonstrate a range of innovation capabilities when they collaborate with a regional university research centre. This collaboration is shown to be important to create and exchange new knowledge to advance the firms innovation performance. The study demonstrates the ability of firms to acquire and exploit this knowledge, which is a business competency described as absorptive capacity (AC). AC relies on several antecedents or factors to engage with a collective learning process.

243p runthenight04 02-02-2023 7 3   Download

Citrus production is declining worldwide due to several biotic and abiotic factors. The diseases caused by Phytophthora spp. present major economic risks since they are soil-borne and spread quickly if environmental conditions are favorable, or irrigation is poorly managed. Phytophthora species are present in all citrus-producing areas around the world causing significant losses in crop yield and affecting tree health.

13p lyhuyenthu 31-01-2023 7 2   Download

Executive function (EF) is vital to human beings. It has been linked to many genes and family environmental factors in separate studies, but few studies have examined the potential interactions between gene(s) and environmental factor(s).

11p vihagrid 30-01-2023 4 3   Download

Ultraviolet (UV) crosslinking and immunoprecipitation (CLIP) identifies the sites on RNAs that are in direct contact with RNA-binding proteins (RBPs). Several variants of CLIP exist, which require different computational approaches for analysis.

21p vialfrednobel 29-01-2022 13 0   Download

Xylella fastidiosa (Xf) is a gram negative bacterium inhabiting the plant vascular system. In most species this bacterium lives as a benign symbiote, but in several agriculturally important plants (e.g. coffee, citrus, grapevine) Xf is pathogenic. Xf has four loci encoding homologues to hemolysin RTX proteins, virulence factors involved in a wide range of plant pathogen interactions.

11p vibeauty 23-10-2021 6 1   Download

Phytophthora infestans is a plant pathogen that causes an important plant disease known as late blight in potato plants (Solanum tuberosum) and several other solanaceous hosts. This disease is the main factor affecting potato crop production worldwide. In spite of the importance of the disease, the molecular mechanisms underlying the compatibility between the pathogen and its hosts are still unknown.

14p viseulgi2711 31-08-2021 23 1   Download

Parts of Europe and the United States have witnessed dramatic losses in commercially managed honey bees over the past decade to what is considered an unsustainable extent. The large-scale loss of bees has considerable implications for the agricultural economy because bees are one of the leading pollinators of numerous crops. Bee declines have been associated with several interactive factors.

20p visilicon2711 20-08-2021 7 1   Download

Transcription factors (TFs) are essential regulators of growth and development in eukaryotes. Basichelix-loop-helix (bHLHs) is one of the most significant TFs families involved in several critical regulatory functions.

13p vijeeni2711 30-06-2021 13 1   Download

Drought stress can severely affect plant growth and crop yield. The cloning and identification of drought-inducible promoters would be of value for genetically-based strategies to improve resistance of crops to drought.

14p vijichea2711 28-05-2021 7 1   Download

Osteoarthritis (OA) of the knee is a common and disabling condition. We wanted to investigate the modifiable risk factors Body Mass Index (BMI) and physical activity, using knee replacement (KR) as a marker for severely symptomatic disease, focusing on the interaction between these risk factors.

11p viannito2711 20-04-2021 8 1   Download

The incidence of knee osteoarthritis (OA) is rising. While several risk factors have been associated with the development of knee OA, this information is not readily accessible to those at risk for osteoarthritis.

12p vioregon2711 22-02-2021 4 2   Download

A standard multi-factor analysis of variance showed the main effect due to years, locations and first order interactions (year x location) were highly significant. The main effect for genotype, first order interaction (varieties x locations), (variety x year) and second order interaction (varieties x locations x year) were highly significant. The highly significant interactions indicate that varieties need to be tested in severe years and locations in order to select stable variety.

11p chauchaungayxua8 03-10-2020 13 2   Download

53BP1 binds to the tumor suppressor p53 and has a key role in DNA damage response and repair. Low 53BP1 expression has been associated with decreased survival in breast cancer and has been shown to interact with several prognostic factors in non-small cell lung cancer.

8p vijisoo2711 29-09-2020 7 1   Download