Severe hypercalcemia

To review the diagnosis and clinical course of a woman with severe, symptomatic hypercalcemia resulting from the use of calcium sulfate beads (CSBs) during orthopedic surgery for knee joint infection.

3p caothientrangnguyen 09-05-2020 17 1   Download

Etiology Humoral hypercalcemia of malignancy (HHM) occurs in up to 20% of patients with cancer. HHM is most common in cancers of the lung, head and neck, skin, esophagus, breast, genitourinary tract, and in multiple myeloma and lymphomas. Several distinct humoral causes of HHM occur, most commonly overproduction of PTHrP. In addition to acting as a circulating humoral factor, bone metastases (e.g., breast, multiple myeloma) may produce PTHrP, leading to local osteolysis and hypercalcemia.

5p thanhongan 07-12-2010 79 3   Download

Vitamin D deficiency, impaired 1,25(OH)2D production (primarily secondary to renal insufficiency), or, rarely, vitamin D resistance also cause hypocalcemia. However, the degree of hypocalcemia in these disorders is generally not as severe as that seen with hypoparathyroidism because the parathyroids are capable of mounting a compensatory increase in PTH secretion. Hypocalcemia may also occur in conditions associated with severe tissue injury such as burns, rhabdomyolysis, tumor lysis, or pancreatitis.

5p ongxaemnumber1 29-11-2010 70 3   Download