Severe inflammation
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This plant contains natural compounds such as iridoids, naphthalene glycosides, and especially anthraquinones and anthraquinone glycosides. [9,10] Several compositions of M. longissima stems and roots have been reported to inhibit the in vitro replication of the hepatitis B virus. [11,12] Thus, the search for TNF-α inhibitors from the M. longissima plant and their natural constituents, especially anthraquinone compounds, by molecular docking approaches is necessary for the discovery of potential drug candidates for inflammation-mediated diseases.
7p dianmotminh02 03-05-2024 5 1 Download
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Interactions between the gut microbiota, diet, and host metabolism contribute to the development of cardiovascular disease, but a firm link between disease-specific gut microbiota alterations and circulating metabolites is lacking.
12p vicwell 29-02-2024 9 1 Download
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HERPUD1 is an important early marker of endoplasmic reticulum stress (ERS) and is involved in the ubiquitination and degradation of several unfolded proteins. However, its role in tumorigenesis is seldom studied, and its role in ovarian cancer is unclear.
20p vileonardodavinci 23-12-2023 5 2 Download
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Granulocyte colony-stimulating factor (G-CSF)-producing lung cancer induces severe inflammation and a high white blood cell (WBC) count and is associated with poor prognosis. A recent case of G-CSF-producing lung adenocarcinoma showed high expression of programmed cell death ligand 1 (PD-L1) and was treated with pembrolizumab as first-line therapy, which was extremely effective. We hypothesized that G-CSF-producing lung cancers are associated with high PD-L1 expression.
6p vialfrednobel 23-12-2023 6 3 Download
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Systemic lupus erythematosus (SLE) is a chronic disease that causes systemic inflammation which affects multiple organs. There is no cure for SLE. Conventional treatment options include antimalarial drugs, corticosteroids, and immune suppressants, but a number of patients are resistant to treatment or suffer from severe side effects.
6p visoros 01-11-2023 3 1 Download
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Given the role of systematic inflammation in cancer progression, lymphocyte-monocyte ratio (LMR) from peripheral blood has been suggested as a biomarker to assess the extent of inflammation in several solid malignancies. However, the role of LMR as a prognostic factor in head and neck cancer was unclear in several meta-analyses, and there is a paucity of literature including patients in North America.
10p visharma 20-10-2023 5 2 Download
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Aprepitant inhibits the development and metastasis of gallbladder cancer via ROS and MAPK activation
Aprepitant, as a neurokinin-1 receptor (NK-1R) antagonist, originally applied for curing chemotherapyinduced nausea and vomiting, has been reported to have significant antitumor effect on several malignant tumors.
14p visharma 20-10-2023 8 2 Download
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Leukocyte adhesion deficiency type 1 (LAD1) is a rare congenital immunodeficiency disease. The cause of disease is determined to be the mutations in the ITGB2 gene that codes for CD18, the beta chain of beta-2 integrins, leads to decreased expression or functioning of CD18. This deficiency leads to severe impairment of leukocyte adhesion to the vascular wall and leukocyte migration to sites of infection and inflammation.
7p vimulcahy 18-09-2023 5 3 Download
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Patchouli (Pogostemon cablin (Blanco) Benth.) is a plant producing an important essential oil plant for the perfume industry. Moreover, it also has a high medicinal value. This study aims to investigate the effects of several factors, including cutting types, cultivating seasons, and commercial rooting stimulants, on the rooting process of patchouli cuttings.
7p viberkshire 09-08-2023 5 2 Download
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Granulomatosis with polyangiitis, formerly known as Wegener granulomatosis, is a necrotizing vasculitis with granulomatous inflammation that belongs to the class of antineutrophil cytoplasmic antibodies-positive diseases.
11p vigamora 23-05-2023 4 2 Download
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MicroRNA-146a rs2910164 is associated with severe preeclampsia in Black South African women on HAART
South African (SA) Black women have a high prevalence of preeclampsia and HIV, both conditions associated with increased inflammation. miR-146a is an inflammatory-associated miR and a common single nucleotide polymorphism (rs2910164) has been associated with several disease conditions.
9p vinarcissa 21-03-2023 3 1 Download
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Acute lung injury (ALI) and its severe form acute respiratory distress syndrome (ARDS) are respiratory failures caused by excessive alveolar inflammation with high mortality. In this study, we investigated the effects of bone marrow mesenchymal stem cells (BMSCs) on lung injury of lipopolysaccharide (LPS)-induced ALI and explored the associated mechanisms. BMSCs were isolated, cultured, identified by staining with CD34 and CD44 surface markers.
13p lyhuyenthu 31-01-2023 3 2 Download
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Several studies investigated the utility of inflammation and nutritional markers in predicting the prognosis in patients with gastric cancer; however, the markers with the best predictive ability remain unclear.
10p vikolindagrabar 27-07-2022 7 1 Download
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To examine whether acute lung injury from direct and indirect origins differ in susceptibility to ventilator-induced lung injury (VILI) and resultant systemic inflammatory responses. During MV more severe lung injury develops after acid instillation as compared to sepsis. HVt causes VILI after acid instillation, but not during sepsis. However, this differential effect was not observed in the systemic release of mediators.
10p viisaacnewton 26-04-2022 10 1 Download
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Inflammation and oxidative stress can contribute to the development and progression of heart failure. This study aimed to investigate the association between inflammatory and oxidative stress markers in dogs with congestive heart failure (CHF). Associations between the disease severity marker N-terminal pro-B-type natriuretic peptide (NT-proBNP) and markers of inflammation and oxidative stress were also determined.
10p vidarwin 23-02-2022 13 1 Download
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The adult worms of Angiostrongylus vasorum reside in the pulmonary artery of dogs and can lead to cardiac, respiratory, and central neurologic signs. Due to luminal obstruction and perivascular inflammation of the pulmonary artery branches, pulmonary hypertension can arise.
6p vigandhi 23-02-2022 11 1 Download
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Postpartum dysgalactia syndrome (PDS) is associated with a significantly higher activation of the inflammatory and stress response at parturition than in the healthy sow. Therefore, reliable and possibly non-invasive biomarkers for substantial increases of inflammation are searched to support the PDS diagnosis.
8p vidarwin 22-02-2022 10 1 Download
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Grisel’s syndrome is a non-traumatic atlantoaxial subluxation associated with inflammatory conditions of the head and neck, which occurs primarily in children. Increased flexibility of the ligaments during inflammation is implicated in the pathogenesis of the subluxation between the axis and atlas. The potential sequelae may be severe, and early diagnosis and treatment of Grisel’s syndrome can prevent tragic outcomes.
4p vizhangzhidong 29-12-2021 14 0 Download
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Previous studies suggest that transient receptor potential (TRP) channels and neurogenic inflammation may be involved in idiopathic pulmonary fbrosis (IPF)-related high cough sensitivity, although the details of mechanism are largely unknown.
14p vimackenziebezos 29-11-2021 7 0 Download
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The neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation that informs clinical decisions regarding recurrence and overall survival in most epithelial cancers. Radiotherapy for head and neck cancer leads to mucositis in almost all patients and severe radiation-mucositis affects their quality of life (QOL).
7p vimahuateng 26-11-2021 9 1 Download