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Severe thrombocytopenia
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Aplastic anemia is an intractable disease characterized by pancytopenia, susceptibility to infection, and difficulty in achieving hemostasis. In patients with severe periodontal disease and aplastic anemia, spontaneous bleeding from the gingival tissue due to thrombocytopenia and during brushing is common, which may further exacerbate dental issues.
8p
vilazada
31-01-2024
5
2
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Tirofiban is a nonpeptide glycoprotein IIb/IIIa receptor antagonist used widely in patients subjected to percutaneous coronary intervention. While the usage of tirofiban sets an important clinical benefit, severe thrombocytopenia can occur with use of this agent.
5p
vitiki
30-01-2024
2
2
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In this report, we describe a very challenging case of a patient with secondary Evans syndrome caused by severe coronavirus disease 2019 infection in a pregnant full-term woman. A 29-year-old full-term pregnant Indonesian woman presented with gross hematuria, dry cough, fever, dyspnea, nausea, anosmia, and fatigue 5 days after confirmation of coronavirus disease 2019 infection.
6p
vilazada
31-01-2024
2
2
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Thrombocytopenia is often considered a risk factor for bleeding, but conversely may be associated with an increased thrombotic risk in several clinical situations. Here we present a patient with arterial thrombosis and chronic disseminated intravascular coagulation caused by metastatic urothelial carcinoma.
5p
vitiki
30-01-2024
3
2
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Spontaneous spinal cord hemorrhage is extremely rare in dengue fever. We report a case of spontaneous spinal intradural hemorrhage in dengue fever associated with severe thrombocytopenia.
4p
vigamora
23-05-2023
4
3
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Hereditary folate malabsorption—a rare disorder caused by impairment of the folate transporter—can develop into severe folate deficiency manifesting as megaloblastic anemia and occasionally thrombocytopenia. Reportedly, megaloblastic anemia can manifest with hemorrhagic episodes, possibly due to ineffective platelet production and platelet dysfunction.
6p
vigamora
23-05-2023
5
2
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Thrombocytopenia is a condition that causes a low amount of blood platelets. Platelets are blood cells that play an essential role in blood coagulation. Therefore, thrombocytopenia can put the patient at risk for mild to severe bleeding.
3p
vinarcissa
21-03-2023
4
1
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Immune thrombocytopenia (ITP) is the most common of the hemorrhagic diseases caused by thrombocytopenia in children. It usually occurs between the ages of 5 and 7 years old and at both sexes. It is difficult to predict ITP basing on bleeding because some severe thrombocytopenia cases have slight purpura or ecchymoses. This study aims to describe the clinical and hematological features of childhood immune thrombocytopenia.
7p
inception36
30-11-2021
8
1
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There is limited real-world safety information on palbociclib for treatment of advanced stage HR+/ HER2- breast cancer. This real-world study found increased risks of several adverse events identified in clinical trials, including neutropenia, leukopenia, and thrombocytopenia, but no increased risk of serious infections or pulmonary embolism when comparing new users of palbociclib-fulvestrant to fulvestrant monotherapy.
13p
vianrose2711
27-04-2021
15
1
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Hip fractures have become a severe public health problem, especially in very elderly patients. Most of them are treated with low molecular weight heparin as prophylaxis or treatment of venous thromboembolism.
4p
vipalau2711
30-12-2020
8
1
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A one year old female Labrador dog was presented to University Veterinary Hospital Kokkalai, with a history of anorexia, weakness, blood in urine and faeces. On physical examination mucous membranes were pale icteric, fever (105.30 F), tachypnoea was noticed. Abdominal palpation revealed splenomegaly which was confirmed by ultrasonography. Haemotological examination revealed leucocytosis, severe macrocytic hypochromic anaemia (VPRC-9.4%) and thrombocytopenia.
5p
trinhthamhodang7
31-08-2020
9
2
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A two and a half year old male Labrador dog was brought with history of in appetence, pyrexia, weakness, vomiting, blood in urine and lateral recumbencysince a week. Clinical examination revealed icteric visible mucousmembrane, dehydration, high fever (105 o F), increased respiratory rate and enlarged superficial lymph nodes with presence of ticks on body surface. Urinalysis revealed haemoglobinuria. Haematological findings revealed severe anemia (Hb- 2.2 g/dl) and thrombocytopenia (88 ×105 /µl). Serum biochemistry showed elevated BUN (102 mg/dl), creatinine (3.
5p
caygaocaolon6
30-07-2020
13
1
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The overall prevalence of thrombocytopenia in neonates admitted to neonatal intensive care units ranges from 22 to 35%. There are only a few small studies that outline the relationship between the severity of thrombocytopenia and the risk of bleeding.
7p
virubber2711
21-03-2020
8
1
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Kasabach-Merritt syndrome (KMS) is characterized by giant hemangiomas and severe thrombocytopenia, which may result in life-threatening multi-organ hemorrhage. This study evaluated the clinical characteristics, treatments, and outcomes in neonates with KMS, in order to find out the optimal therapy.
7p
vichengshin2711
29-02-2020
14
0
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Dengue infections are currently one of the most rapidly emerging arboviral infections in the world. There is high mortality associated with severe dengue infection so we conducted study to predict various factors indicating severity of dengue infection. This cross- sectional study conducted in tertiary care hospital of central India. Data associated with various clinical features of dengue infection collected in predesigned questionnaire.
6p
chauchaungayxua3
07-02-2020
7
0
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Severe heparin-induced thrombocytopenia: when the obvious is not obvious, a case report...
5p
thulanh27
14-12-2011
38
2
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Severe isolated thrombocytopenia after clopidogrel and pentoxifylline therapy: a case report...
3p
thulanh25
07-12-2011
38
2
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Adverse Reactions Adverse drug reactions are frequently classified by mechanism as either dose-related ("toxic") or unpredictable. Unpredictable reactions are either idiosyncratic or allergic. Dose-related reactions include aminoglycoside-induced nephrotoxicity, linezolid-induced thrombocytopenia, penicillin-induced seizures, and vancomycin-induced anaphylactoid reactions. Many of these reactions can be avoided by reducing dosage in patients with impaired renal function, limiting the duration of therapy, or reducing the rate of administration.
9p
colgate_colgate
21-12-2010
61
3
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Differential Diagnosis The differential diagnosis between DIC and severe liver disease is challenging and requires serial measurements of the laboratory parameters of DIC. Patients with severe liver disease are at risk for bleeding and manifest laboratory features including thrombocytopenia (due to platelet sequestration, portal hypertension, or hypersplenism), decreased synthesis of coagulation factors and natural anticoagulants, and elevated levels of FDP due to reduced hepatic clearance. However, in contrast to DIC, these laboratory parameters in liver disease do not change rapidly.
5p
thanhongan
07-12-2010
130
2
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Coagulation Disorders Associated with Liver Failure The liver is central to hemostasis because it is the site of synthesis and clearance of most procoagulant and natural anticoagulant proteins and of essential components of the fibrinolytic system. Liver failure is associated with a high risk of bleeding due to deficient synthesis of procoagulant factors and enhanced fibrinolysis. Thrombocytopenia is common in patients with liver disease and may be due to congestive splenomegaly (hypersplenism), or immune-mediated shortened platelet life span (primary biliary cirrhosis).
5p
thanhongan
07-12-2010
68
2
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