Sexual dysfunction

Determine acute and subchronic toxicity of TD0014 in experimental animals; evaluate androgenic activity and effects on erectile function of TD0014 in experimental animals; evaluate the effects of TD0014 on sodium valproate-induced reproductive decline in male rats.

27p tamynhan0 15-06-2020 7 1   Download

Xìu Tại Thuốc Chuyện trục trặc sinh lý là một vấn đề làm rất nhiều ông lo nghĩ. Lực bất tùng tâm hoặc thằng nhỏ khó dạy là điều thường hay xảy ra nhất là vào lúc tuổi đời đang bước vào hoàng hôn. Thống kê Hoa kỳ cho biết 52% đàn ông trên 40 tuổi có vấn đề rối loạn sinh lý (sexual dysfunction) ở mức độ ít nhiều và khác nhau tùy theo mỗi người. Có vô số nguyên nhân dẫn đến chuyện chẳng đặng đừng nầy nhưng các nhà khoa học cho biết 25% là do...

7p sinhtodau111 25-04-2011 74 3   Download

The skin has many essential functions, including protection, thermoregulation, immune responsiveness, biochemical synthesis, sensory detection, and social and sexual communication. Therapy to correct dysfunction in any of these activities may be delivered topically, systemically, intralesionally, or through ultraviolet radiation.

32p vanass 01-04-2011 79 8   Download

The skin has many essential functions, including protection, thermoregulation, immune responsiveness, biochemical synthesis, sensory detection, and social and sexual communication. Therapy to correct dysfunction in any of these activities may be delivered topically, systemically, intralesionally, or through ultraviolet radiation.

30p vanass 01-04-2011 60 7   Download

Physiology of the Female Sexual Response The female sexual response requires the presence of estrogens. A role for androgens is also likely but less well-established. In the CNS, estrogens and androgens work synergistically to enhance sexual arousal and response. A number of studies report enhanced libido in women during preovulatory phases of the menstrual cycle, suggesting that hormones involved in the ovulatory surge (e.g., estrogens) increase desire. Sexual motivation is heavily influenced by context, including the environment and partner factors.

5p ongxaemnumber1 29-11-2010 98 6   Download

Intraurethral Alprostadil If a patient fails to respond to oral agents, a reasonable next choice is intraurethral or self-injection of vasoactive substances. Intraurethral prostaglandin E1 (alprostadil), in the form of a semisolid pellet (doses of 125–1000 µg), is delivered with an applicator. Approximately 65% of men receiving intraurethral alprostadil respond with an erection when tested in the office, but only 50% of those achieve successful coitus at home. Intraurethral insertion is associated with a markedly reduced incidence of priapism in comparison to intracavernosal injection.

5p ongxaemnumber1 29-11-2010 73 3   Download

Approach to the Patient: Erectile Dysfunction A good physician-patient relationship helps to unravel the possible causes of ED, many of which require discussion of personal and sometimes embarrassing topics. For this reason, a primary care provider is often ideally suited to initiate the evaluation. A complete medical and sexual history should be taken in an effort to assess whether the cause of ED is organic, psychogenic, or multifactorial (Fig. 492). Initial questions should focus on the onset of symptoms, the presence and duration of partial erections, and the progression of ED.

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Male Sexual Dysfunction: Treatment Patient Education Patient and partner education is essential in the treatment of ED. In goaldirected therapy, education facilitates understanding of the disease, results of the tests, and selection of treatment. Discussion of treatment options helps to clarify how treatment is best offered and stratify first- and second-line therapies. Patients with high-risk lifestyle issues, such as smoking, alcohol abuse, or recreational drug use, should be counseled on the role these factors play in the development of ED.

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Neurogenic Disorders that affect the sacral spinal cord or the autonomic fibers to the penis preclude nervous system relaxation of penile smooth muscle, thus leading to ED. In patients with spinal cord injury, the degree of ED depends on the completeness and level of the lesion. Patients with incomplete lesions or injuries to the upper part of the spinal cord are more likely to retain erectile capabilities than those with complete lesions or injuries to the lower part.

7p ongxaemnumber1 29-11-2010 65 6   Download

Pathways that control erection and detumescence. A. Erection is mediated by cholinergic parasympathetic pathways, and nonadrenergic, noncholinergic (NANC) pathways, which release nitric oxide (NO). Endothelial cells also release NO, which induces vascular smooth-muscle cell relaxation, allowing enhanced blood flow, and leading to erection. Detumescence is mediated by sympathetic pathways that release norepinephrine and stimulate α-adrenergic pathways, leading to contraction of vascular smooth-muscle cells. Endothelin, released from endothelial cells, also induces contraction.

5p ongxaemnumber1 29-11-2010 63 4   Download

Female Sexual Dysfunction: Treatment General An open discussion with the patient is important as couples may need to be educated about normal anatomy and physiologic responses, including role of orgasm in sexual encounters. Physiologic changes associated with aging and/or disease should be explained. Couples may need to be reminded that clitoral stimulation rather than coital intromission may be more beneficial. Behavioral modification and nonpharmacologic therapies should be a first step. Patient and partner counseling may improve communication and relationship strains.

5p ongxaemnumber1 29-11-2010 93 5   Download