Short linear motifs
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Animal genomes contain thousands of long noncoding RNA (lncRNA) genes, a growing subset of which are thought to be functionally important. This functionality is often mediated by short sequence elements scattered throughout the RNA sequence that correspond to binding sites for small RNAs and RNA binding proteins.
31p viarchimedes 26-01-2022 21 0 Download
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Short linear protein motifs are attracting increasing attention as functionally independent sites, typically 3–10 amino acids in length that are enriched in disordered regions of proteins. Multiple methods have recently been proposed to discover over-represented motifs within a set of proteins based on simple regular expressions.
9p viwyoming2711 16-12-2020 9 0 Download
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Analyzing the amino acid sequence of an intrinsically disordered protein (IDP) in an evolutionary context can yield novel insights on the functional role of disordered regions and sequence element(s).
9p vikentucky2711 24-11-2020 9 1 Download
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Short linear motifs in host organisms proteins can be mimicked by viruses to create protein-protein interactions that disable or control metabolic pathways. Given that viral linear motif instances of host motif regular expressions can be found by chance, it is necessary to develop filtering methods of functional linear motifs.
11p vioklahoma2711 19-11-2020 10 1 Download
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Molecular recognition features (MoRFs) are one important type of disordered segments that can promote specific protein-protein interactions. They are located within longer intrinsically disordered regions (IDRs), and undergo disorder-to-order transitions upon binding to their interaction partners.
11p vicolorado2711 23-10-2020 22 2 Download
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Countering this, a second group points to the high and possibly still rising unemployment in the U.S. and Europe, coupled with excess capacity, as an effective barrier to any near-term outbreak of inflation in 2009—or even 2010. In the aggregate, they see potential supply still looking much higher than demand. This group worries that any withdrawal of stimulus now would be premature—much as in the Great Depression, when U.S. fiscal and monetary retrenchment in 1937 cut short a nascent economic recovery after 1933.
18p taisaocothedung 09-01-2013 50 4 Download