Short reads
-
Investigation of effective approaches for supporting students’ linguistic and intercultural competence in the process of learning English as an international lingua franca has generally been an issue of great concern for teachers and researchers in language education. The paper finally puts forward the suggestion that short literary texts of cultures around the world might be considered as one of the meaningful inputs in B1 EFL classrooms.
10p vialicene 02-07-2024 1 0 Download
-
Studies have shown that complex structural variants (cxSVs) contribute to human genomic variation and can cause Mendelian disease. We aimed to identify cxSVs relevant to Mendelian disease using short-read whole-genome sequencing (WGS), resolve the precise variant configuration and investigate possible mechanisms of cxSV formation.
10p vibransone 28-03-2024 4 1 Download
-
Microsatellite expansion, such as trinucleotide repeat expansion (TRE), is known to cause a number of genetic diseases. Sanger sequencing and next-generation short-read sequencing are unable to interrogate TRE reliably. We developed a novel algorithm called RepeatHMM to estimate repeat counts from long-read sequencing data.
16p vioraclene 31-03-2024 9 2 Download
-
Expansions of short tandem repeats are the cause of many neurogenetic disorders including familial amyotrophic lateral sclerosis, Huntington disease, and many others. Multiple methods have been recently developed that can identify repeat expansions in whole genome or exome sequencing data.
10p viellison 28-03-2024 3 1 Download
-
Long-read sequencing (LRS) techniques have been very successful in identifying structural variants (SVs). However, the high error rate of LRS made the detection of small variants (substitutions and short indels
15p vicwell 29-02-2024 1 1 Download
-
Long-read whole genome sequencing (lrWGS) has the potential to address the technical limitations of exome sequencing in ways not possible by short-read WGS. However, its utility in autosomal recessive Mendelian diseases is largely unknown. Methods In a cohort of 34 families in which the suspected autosomal recessive diseases remained undiagnosed by exome sequencing, lrWGS was performed on the Pacifc Bioscience Sequel IIe platform.
16p vicwell 29-02-2024 2 2 Download
-
101 Conversations in Intermediate English prepares you to speak English in the real world. Unlike the contrived and unnatural dialogues in your textbook, the 101 authentic conversations in this book offer you simple but authentic spoken English that you can study away from the pressure of face-to-face conversation. The conversations in this book tell the story of a detective in London. You’ll experience the story by following the conversations the characters have with one another.
124p haojiubujain05 09-08-2023 11 8 Download
-
101 Conversations in Simple English prepares you to speak English in the real world. Unlike the contrived and unnatural dialogues in your textbook, the 101 authentic conversations in this book offer you simple but authentic spoken English that you can study away from the pressure of face-to-face conversation. The conversations in this book tell the story of six people in London. You’ll experience the story by following the conversations the characters have with one another.
127p haojiubujain05 09-08-2023 11 8 Download
-
Ebook 501 reading comprehension questions: Part 1 includes contents: Chapter 1 vocabulary; chapter 2 analogies; chapter 3 main ideas, themes; chapter 4 topic sentences; chapter 5 short passages. Please refer to the documentation for more details.
98p haojiubujain03 09-08-2023 6 4 Download
-
Ebook Phonics for dummies: Part 1 presents the following content: Chapter 1: pondering the power of phonics; chapter 2: setting up your teaching aids and techniques; chapter 3: starting with simple consonants and a vowel; chapter 4: finishing short vowels and seeing patterns; chapter 5: joining consonants together to make more sounds; chapter 6: pursuing plurals and compound words; chapter 7: making long vowels sounds; chapter 8: presenting diverse vowel sounds of a, o, and u; chapter 9: delving into diphthongs and shortcuts.
187p haojiubujain03 09-08-2023 14 4 Download
-
Lecture Business research methods (12/e) - Chapter 1: Research in business. After reading this chapter, you should understand: What business research is and how it differs from business decision support systems and business intelligence systems, trends affecting business research and the emerging hierarchy of business decision makers, the distinction between good business research and research that falls short of professional quality, the nature of the research process.
39p haojiubujain04 27-07-2023 11 7 Download
-
Consumers increasingly turn to the internet in search of health-related information; and they want their questions answered with short and precise passages, rather than needing to analyze lists of relevant documents returned by search engines and reading each document to find an answer. We aim to answer consumer health questions with information from reliable sources.
8p vighostrider 25-05-2023 6 2 Download
-
Chapter 23 - Relevant costing for managerial decisions. After you have read this chapter you should be able to: Describe the importance of relevant costs for short-term decisions, evaluate short-term managerial decisions using relevant costs, determine product selling price based on total costs, identify relevant costs and apply them to managerial decisions,...
18p runordie9 27-09-2022 10 2 Download
-
Short tandem repeat (STR) expansions have been identified as the causal DNA mutation in dozens of Mendelian diseases. Most existing tools for detecting STR variation with short reads do so within the read length and so are unable to detect the majority of pathogenic expansions.
13p vigalileogalilei 27-02-2022 16 1 Download
-
The human genome contains “dark” gene regions that cannot be adequately assembled or aligned using standard short-read sequencing technologies, preventing researchers from identifying mutations within these gene regions that may be relevant to human disease.
23p vigalileogalilei 27-02-2022 9 1 Download
-
Current genotyping approaches for single-nucleotide variations rely on short, accurate reads from second-generation sequencing devices. Presently, third-generation sequencing platforms are rapidly becoming more widespread, yet approaches for leveraging their long but error-prone reads for genotyping are lacking.
16p vigalileogalilei 27-02-2022 9 1 Download
-
The vast quantities of short-read sequencing data being generated are often exchanged and stored as aligned reads. However, aligned data becomes outdated as new reference genomes and alignment methods become available.
6p vigalileogalilei 27-02-2022 9 1 Download
-
We describe a method that adds long-read sequencing to a mix of technologies used to assemble a highly complex cattle rumen microbial community, and provide a comparison to short read-based methods. Long-read alignments and Hi-C linkage between contigs support the identification of 188 novel virus-host associations and the determination of phage life cycle states in the rumen microbial community.
18p vielonmusk 30-01-2022 15 0 Download
-
Recent research into structural variants (SVs) has established their importance to medicine and molecular biology, elucidating their role in various diseases, regulation of gene expression, ethnic diversity, and large-scale chromosome evolution—giving rise to the differences within populations and among species
14p vielonmusk 30-01-2022 9 0 Download
-
As metagenomic studies move to increasing numbers of samples, communities like the human gut may benefit more from the assembly of abundant microbes in many samples, rather than the exhaustive assembly of fewer samples. We term this approach leaderboard metagenome sequencing.
14p vielonmusk 30-01-2022 9 0 Download