Short tandem repeat
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Expansions of short tandem repeats are the cause of many neurogenetic disorders including familial amyotrophic lateral sclerosis, Huntington disease, and many others. Multiple methods have been recently developed that can identify repeat expansions in whole genome or exome sequencing data.
10p viellison 28-03-2024 1 1 Download
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Much of the data resolution of the haploid non-recombining Y chromosome (NRY) haplogroup O in East Asia are still rudimentary and could be an explanatory factor for current debates on the settlement history of Island Southeast Asia (ISEA). Here, 81 slowly evolving markers (mostly SNPs) and 17 Y-chromosomal short tandem repeats were used to achieve higher level molecular resolution.
23p vinarcissa 21-03-2023 6 1 Download
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An STR locus with tri-allelic pattern is occasionally observed in routine forensic casework. The extra copy of TPOX locus with tri-allelic pattern in populations has been assumed to be inserted into an X chromosome, which took place forth before the Bantu expansion in Africa.
9p vihagrid 30-01-2023 3 3 Download
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Microsatellite loci have been used extensively over the past two decades to study the genetic characteristics of non-model species. The ease of microsatellite development and ability to adapt markers from related species has led to the proliferation of available markers for many commonly studied species.
14p vihagrid 30-01-2023 9 3 Download
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The majority of the Kazakhs from South Kazakhstan belongs to the 12 clans of the Senior Zhuz. According to traditional genealogy, nine of these clans have a common ancestor and constitute the Uissun tribe.
8p vihagrid 30-01-2023 8 3 Download
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Short tandem repeats (STRs) play a crucial role in genetic diseases. However, classic disease models such as inbred mice lack such genome-wide data in public domain. The examination of STR alleles present in the protein coding regions (are known as protein tandem repeats or PTR) can provide additional functional layer of phenotype regulars.
6p vihagrid 30-01-2023 8 3 Download
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While of predominant abundance across vertebrate genomes and significant biological implications, the relevance of short tandem repeats (STRs) (also known as microsatellites) to speciation remains largely elusive and attributed to random coincidence for the most part.
11p vihagrid 30-01-2023 8 3 Download
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Short tandem repeat (STR) expansions have been identified as the causal DNA mutation in dozens of Mendelian diseases. Most existing tools for detecting STR variation with short reads do so within the read length and so are unable to detect the majority of pathogenic expansions.
13p vigalileogalilei 27-02-2022 16 1 Download
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Short tandem repeats (STRs) contribute significantly to de novo mutagenesis, driving phenotypic diversity and genetic disease. Although highly diverse, their repetitive sequences induce DNA polymerase slippage and stalling, leading to length and sequence variation.
26p viarchimedes 26-01-2022 3 0 Download
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Repeat expansions are responsible for over 40 monogenic disorders, and undoubtedly more pathogenic repeat expansions remain to be discovered. Existing methods for detecting repeat expansions in short-read sequencing data require predefined repeat catalogs. Recent discoveries emphasize the need for methods that do not require pre-specified candidate repeats.
14p viarchimedes 26-01-2022 8 0 Download
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: Increased availability of genome assemblies for non-model organisms has resulted in invaluable biological and genomic insight into numerous vertebrates, including teleosts. Sequencing of the Atlantic cod (Gadus morhua) genome and the genomes of many of its relatives (Gadiformes) demonstrated a shared loss of the major histocompatibility complex (MHC) II genes 100 million years ago. An improved version of the Atlantic cod genome assembly shows an extreme density of tandem repeats compared to other vertebrate genome assemblies.
17p vibeauty 23-10-2021 1 0 Download
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Microsatellites, or Simple Sequence Repeats (SSRs), are short tandem repeats of 1–6 nt motifs present in all genomes. Emerging evidence points to their role in cellular processes and gene regulation. Despite the huge resource of genomic information currently available, SSRs have been studied in a limited context and compared across relatively few species.
14p visilicon2711 20-08-2021 6 1 Download
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In the present study, we used long-PCR amplification coupled with Next-Generation Sequencing (NGS) to obtain complete mitochondrial (mt) genomes of individual ticks and unprecedently performed precise annotation of these mt genomes.
11p vijeeni2711 24-07-2021 13 0 Download
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The ubiquitous presence of short tandem repeats (STRs) in virtually all genomes implicates their functional relevance, while a widely-accepted definition of STR is yet to be established. Previous studies majorly focus on relatively longer STRs, while shorter repeats were generally excluded.
14p vijeeni2711 30-06-2021 9 1 Download
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Short tandem repeats (STRs) are found in many prokaryotic and eukaryotic genomes, and are commonly used as genetic markers, in particular for identity and parental testing in DNA forensics. The unstable expansion of some STRs was associated with various genetic disorders (e.g., the Huntington disease), and thus was used in genetic testing for screening individuals at high risk.
6p viflorida2711 30-10-2020 9 0 Download
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Evidence has accumulated which suggests that sex steroids influence colorectal cancer development and progression. We therefore assessed the association of repeat polymorphisms in the estrogen receptor β gene (ESR2) and the androgen receptor gene (AR) with colorectal cancer risk and prognosis.
9p vilisa271 22-09-2020 9 1 Download
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Microsatellites are short tandem nucleotide repeats usually 2-6 bp, highly polymorphic in nature, and are found scattered throughout the genome of eukaryotes. Microsatellites are also called short tandem repeats (STR) or simple sequence repeats (SSR), due to the nature of nucleotide repeats which can be mono, di, tri, penta and hexa. They are the most commonest markers used for genetic characterization in various farm animal, which is based on DNA sequence polymorphisms, which are identified by constructing PCR primers for the DNA flanking the microsatellite region.
13p trinhthamhodang4 22-03-2020 15 1 Download
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Bài viết xây dựng kỹ thuật microsatellite - DNA để xác định tình trạng mang gen bệnh của các thành viên nữ trong gia đình bệnh nhân HA dựa vào phân tích các vùng trình tự lặp lại (short tandem repeat - STR), so sánh với kết quả phát hiện đột biến trực tiếp bằng kỹ thuật giải trình tự gen.5 gia đình bệnh nhân HA bao gồm bệnh nhân và các thành viên nữ trong gia đình đã được lựa chọn vào nghiên cứu. Kết quả cho thấy, 6 thành viên nữ của 3 gia đình bệnh nhân HA (mẹ, bác họ, chị họ hoặc em gái) đã được phát hiện là người lành mang gen bệnh.
9p quenchua1 04-11-2019 40 0 Download
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Y-chromosome microsatellites or short tandem repeats (STRs) have been proved to be ideal markers to delineate the differences between individuals in human population. Nowadays, Y-STR testing using the PowerPlex® Y23 amplification kit is considered as an extremely sensitive analysis method and has the potential to be used to perform forensic caseworks, and to explore the complexity in population substructures.
7p viathena2711 08-10-2019 12 0 Download
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The genus Salvia L. contains about 1000 species, more than 40 of which are endemic to the Mediterranean region. Species boundaries and classifications of this genus have been mainly conducted based on morphological and anatomical characteristics.
9p vikimsa 22-02-2019 17 1 Download