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Signaling cascades

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  • Volume 3 of the book series Biomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems aims at presenting major sets of signaling receptors mainly located at the plasma membrane, 1 in a modeling framework rather than biological perspective. Collecting signaling effectors, their main interactions, and major properties are the first tasks required for any modeling of cell signaling processes. The major objective is to comprehend the complexity of natural phenomena to model these events. In other words, to yield the maximal amount of known information (i.e.

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  • MicroRNAs (miRNAs) regulate gene expression post-transcriptionally by binding to target mRNAs in a sequence-specific manner. A large number of genes appear to be the target of miRNAs, and an essential role for miRNAs in the regulation of various conserved cell signaling cascades, such as mitogen-activated protein kinase, Notch and Hedgehog

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:The p38 mitogen-activated protein kinase signaling cascade in CD4 T cells...

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Higher polymerase activity of a human influenza virus enhances activation of the hemagglutinin-induced Raf/MEK/ERK signal cascade

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  • (BQ) Part 1 of the document Systems biology and control theory has contents: A primer on control engineering, modeling and analysis of stochastic biochemical networks, spatial modeling, quantifying properties of cell signaling cascades, graph s and the dynamics of biochemical networks,... and other contents. Invite you to consult the details.

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  • Accumulating evidence indicates that G protein signaling plays an active role in the regulation of cell survival. Our previous study demonstrated the regulatory effects of Gi⁄ o proteins in nerve growth factor-induced activa-tion of pro-survival Akt kinase. In the present study we explored the role of various members of the Gs,Gq⁄ 11 and G12⁄ 13 subfamilies in the regula-tion of Akt in cultured mammalian cells.

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  • Interleukin (IL)-6-type cytokines exert their effects through activation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling cascade. The JAK/STAT pathways play an important role in rheumatoid arthritis, since JAK inhibitors have exhibited dramatic effects on rheumatoid arthritis (RA) in clinical trials. In this study, we investigated the molecular effects of a small molecule JAK inhibitor, CP690,550 on the JAK/STAT signaling pathways and examined the role of JAK kinases in rheumatoid synovitis....

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  • Death-associated protein kinase (DAPK) regulates many distinct signalling events, including apoptosis, autophagy and membrane blebbing. The role of DAPK in the blebbing process is only beginning to be understood and, in this review, we will first summarize what is known about the cytoskeletal proteins and signalling cascades that participate in bleb growth and retrac-tion and then highlight how DAPK integrates with these processes.

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  • The mechanism by which the CXC chemokine platelet fac-tor 4 (PF-4) inhibits endothelial cell proliferation is unclear. The heparin-binding domains of PF-4 have been reported to prevent vascular endothelial growth factor 165 (VEGF165 ) andfibroblast growth factor 2 (FGF2) frominteractingwith their receptors. However, other studies have suggested that PF-4 acts via heparin-binding independent interactions. Here, we compared the effects of PF-4 on the signalling events involved in the proliferation induced by VEGF165 , which binds heparin, and by VEGF121 , which does not....

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  • There is extensive evidence that FcR c-chain couples to the collagen receptor glycoprotein VI (GPVI) and becomes phosphorylated on tyrosines upon receptor cross-linking. However, it is not established whether this receptor complex is sufficient to initiate the signalling cascade. We transfected GPVI and the FcR c-chain into the human erythroleukaemia cell line K562, which lacks detectable expression of GPVI and the FcR c-chain. The results show that GPVI is unable to signal when expressed alone, despite its surface expression, upon stimulation with the snake C-type lectin, convulxin....

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  • Lecture Digital signal processing - Chapter 6 introduce transfer function and digital filter realization. In this chapter, you will learn to: Transfer functions (Impulse response, difference equation, impulse response,...), digital filter realization (Direct form, canonical form, cascade form).

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  • Signaling cascades, in addition to proteins with obvious signaling-relevant activities (e.g. protein kinases or receptors), also employ dedicated ‘inactive’ proteins whose functions appear to be the organization of the former com-ponents into higher order complexes through protein–protein interactions. The core function of signaling adaptors, anchors and scaffolds is the recruitment of proteins into one macromolecular complex.

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  • Protein kinases drive the cellular signal transduction networks that underlie the regulation of growth, survival and differentiation. To repair the deregu-lations of signaling cascades that are associated with numerous disease states, therapeutic strategies, based on controlling aberrant protein kinase activity, are emerging.

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  • Erythropoietin (Epo) is a hematopoietic cytokine that is crucial for the differentiation and proliferation of erythroid progenitor cells. Epo acts on its target cells by inducing homodimerization of the erythropoietin receptor (EpoR), thereby triggering intracellular signaling cascades. The EpoR encompasses eight tyrosine motifs on its cytoplasmic tail that have been shown to recruit a number of regulatory proteins.

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  • Motivation and Example Adaptive Filter Structure Performance and Robustness Issues Error and Energy Measures Robust Adaptive Filtering Energy Bounds and Passivity Relations Min-Max Optimality of Adaptive Gradient Algorithms Comparison of LMS and RLS Algorithms Time-Domain Feedback Analysis Ali H. Sayed University of California, Los Angeles Markus Rupp Bell Laboratories Lucent Technologies Time-Domain Analysis • l2 −Stability and the Small Gain Condition • Energy Propagation in the Feedback Cascade • A Deterministic Convergence Analysis 20.10Filtered-Error Gradient Algorithms 20.

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  • This book addresses different aspects of the research field and a wide range of topics in speech signal processing, speech recognition and language processing. The chapters are divided in three different sections: Speech Signal Modeling, Speech Recognition and Applications. The chapters in the first section cover some essential topics in speech signal processing used for building speech recognition as well as for speech synthesis systems: speech feature enhancement, speech feature vector dimensionality reduction, segmentation of speech frames into phonetic segments. ...

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  • EURASIP Journal on Applied Signal Processing 2003:12, 1257–1264 c 2003 Hindawi Publishing Corporation The Fractional Fourier Transform and Its Application to Energy Localization Problems Patrick J. Oonincx Department of Nautical Sciences, Royal Netherlands Naval College (KIM), P.O. Box 10000, 1780 CA Den Helder, The Netherlands Email: p.j.oonincx@kim.nl Hennie G. ter Morsche Department of Mathematics and Computer Science, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands Email: morscheh@win.tue.

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  • The building blocks of most signal transduction pathways are pairs of enzymes, such as kinases and phosphatases, that control the activity of pro-tein targets by covalent modification. It has previously been shown [Gold-beter A & Koshland DE (1981)Proc Natl Acad Sci USA78, 6840–6844] that these systems can be highly sensitive to changes in stimuli if their cata-lysing enzymes are saturated with their target protein substrates.

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  • Flow of genetic information. Multiple extracellular signals activate intracellular signal cascades that result in altered regulation of gene expression through the interaction of transcription factors with regulatory regions of genes. RNA polymerase transcribes DNA into RNA that is processed to mRNA by excision of intronic sequences. The mRNA is translated into a polypeptide chain to form the mature protein after undergoing posttranslational processing.

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  • Mitogen-activated protein kinase (MAPK) cascades play important roles in mediating pathogen responses and reactive oxygen species signaling. In plants, MAPKs are classified into four major groups (A–D). Previous stud-ies have mainly focused on groups A and B, but little is known about group C.

    pdf12p cosis54 05-01-2013 36 2   Download

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