Signals of danger

Hepatocellular carcinoma (HCC) is considered one of the most common cancers, characterized by low early detection and high mortality rates, and is a global health challenge. Immunogenic cell death (ICD) is defined as a specific type of regulated cell death (RCD) capable of reshaping the tumor immune microenvironment by releasing danger signals that trigger immune responses, which would contribute to immunotherapy.

21p visharma 20-10-2023 3 2   Download

protect endangered tissueBenzoxazoles are DNA base bioisosteres and studies suggest that their derivatives have antiproliferative activities. Based on their antiproliferative activities they have been mostly studied as new generation anticancer drugs. In our study we exploited their antiproliferative effect, aiming to delineate bisbenzoxazole derivatives’ (RHE 231 and RHE 238) potential antiinflammatory effect on mouse macrophages that are activated in vitro through danger signal LPS stimulation. RAW 267.

15p tudichquannguyet 29-11-2021 10 1   Download

Inflammasomes are supramolecular protein complexes implicated in the detection of pathogens or danger-associated molecules and are responsible for mounting the first line of innate immune response to counteract these signals and restore tissue homeostasis. Among different inflammasomes identified so far, NLRP3 is of main interest since mutations in Nlrp3 gene are associated with autoinflammatory diseases such as Muckle–Wells syndrome, neonatal onset multisystem inflammatory disease, and familial cold urticaria/autoinflammatory syndrome.

11p thiencuuchu 27-11-2021 9 1   Download

Forager bees communicate their floral findings in order to recruit other worker bees of the hive to forage in the same area. The factors that determine recruiting success are including evaluations of the quality of nectar and/or pollen brought in. The waggle dance and odor plume are the two hypotheses for explaining “foragers recruit other workers bees in hive”. The dance theory is far more widely accepted, and has far more empirical support than the odor theory.

15p kethamoi5 03-06-2020 9 0   Download

It is well-documented that the intensity of a self-generated somatosensory stimulus is perceived to be attenuated in respect to an identical stimulus generated by others. At present, it is not clear whether such a phenomenon, known as somatosensory attenuation, is based not only on feedforward motor signals but also on re-afferences towards the body.

5p trinhthamhodang1 14-11-2019 8 0   Download

Reflects the Regulations, which implement a European Council Directive on minimum requirements for provision of workplace safety signs. The Directive standardised use throughout EU member states to ensure particular signs provide the same message wherever witnessed. This guidance contains full colour sign reproduction throughout and is separated into three parts covering regulatory requirements, safety sign usage and a specific study of fire safety signs. With full text of the Regulations, which apply to all workplaces or activities where people are employed....

46p holigon10 04-09-2013 88 12   Download

Antimicrobial peptides participate in innate host defense by directly elimi-nating pathogens as a result of their ability to damage the microbial mem-brane and by providing danger signals that will recruit innate immune cells to the site of infection. Dermaseptin DA4 (DRS-DA4), a new antimicrobial peptide of the dermaseptin superfamily, was identified based on its chemo-tactic properties, contrasting with the currently used microbicidal proper-ties assessment.

14p viettel02 20-02-2013 34 2   Download

Pain is an unpleasant but very important biological signal for danger. Nociception is necessary for survival and maintaining the integrity of the organism in a potentially hostile environment. Pain is both a sensory experience and a perceptual metaphor for damage and it is activated by noxious stimuli that act on a complex pain sensory apparatus. However, chronic pain having no more a protective role can become a ruining disease itself, termed "neuropathic pain".

126p mientrung102 30-01-2013 44 4   Download