Significant risk factors
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This study aimed to assess lower limb strength and some related factors among older people with dementia examined and treated at the National Geriatric Hospital. Three-quarters of older dementia patients have impaired lower limb strength. Our results highlighted that diabetes, and geriatric syndromes such as malnutrition, high fall risk, dependence, and partial dependence were significantly associated with lower limb strength in older patients with dementia.
9p vikoch 27-06-2024 2 1 Download
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Chronic obstructive pulmonary disease (COPD) is a significant global health issue, suspected to elevate the risk for various cancers. This study sought to discern whether COPD serves as a risk marker or a causative factor for prevalent cancers.
12p vishanshan 27-06-2024 1 1 Download
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Hypertension is one of the leading risk factors for death, one of the main risks of cardiovascular disease. Clinical characteristics of hypertension are diverse, the early detection of symptoms of hypertension contributes significantly to early diagnosis and treatment. Describe the clinical and subclinical characteristics of hypertensive children being treated at the Cardiology Department, Can Tho Children’s Hospital.
6p vikoch 27-06-2024 2 1 Download
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Pancreatic cancer, a highly fatal malignancy, has shown a global rise in the incidence and mortality rates. However, these rates vary significantly across diferent regions worldwide. This study aims to assess the incidence and mortality of pancreatic cancer in Saudi Arabia.
10p vikoch 27-06-2024 3 1 Download
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Breast cancer is a common cause for central nervous system (CNS) metastasis, resulting in a significant reduction in overall survival. Germline pathogenic variants (PVs) in BRCA1/2 are the most common genetic risk factor for breast cancer, associated with poor prognostic factors. This study sought to explore the patterns and outcome of CNS metastases in breast cancer patients with germline PVs in BRCA1/2 genes.
12p vikoch 27-06-2024 1 1 Download
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Most patients with intrahepatic cholangiocarcinoma (ICC) have developed distant metastasis at the time of diagnosis, while there is rear related nomogram to predict the prognosis. The nomogram has good accuracy in predicting prognosis of DM-ICC patients, which would be of good significance to improve the prognosis of these patients.
11p vikoch 27-06-2024 2 1 Download
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Genome-wide association studies of Alzheimer’s disease (AD) have identified a number of significant risk loci, the majority of which lie in non-coding regions of the genome. The lack of causal alleles and considerable polygenicity remains a significant barrier to translation into mechanistic understanding.
10p vibransone 28-03-2024 1 1 Download
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Age-related macular degeneration (AMD) is a common condition of vision loss with disease development strongly influenced by environmental and genetic factors. Recently, 34 loci were associated with AMD at genome-wide significance. So far, little is known about a genetic overlap between AMD and other complex diseases or disease-relevant traits.
13p vioraclene 31-03-2024 7 2 Download
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Basal cell carcinoma (BCC) of the skin is the most common form of human cancer, with more than 90% of tumours presenting with clear genetic activation of the Hedgehog pathway. However, polygenic risk factors affecting mechanisms such as DNA repair and cell cycle checkpoints or which modulate the tumour microenvironment or host immune system play significant roles in determining whether genetic mutations culminate in BCC development.
12p vibransone 28-03-2024 3 2 Download
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Air pollution is one of the leading risk factors for death but also a significant contributor to the global disease burden, affecting quality of life. According to a World Health Organisation (WHO) report, seven million people die from air pollution every year, and 9 out of 10 people worldwide breathe polluted air. Any person can be affected by exposure to polluted air, especially the elderly, children, pregnant women, and people with comorbidities.
9p viellison 28-03-2024 2 1 Download
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African ancestry is a significant risk factor for advanced prostate cancer (PCa). Mortality rates in subSaharan Africa are 2.5-fold greater than global averages. However, the region has largely been excluded from the benefits of whole genome interrogation studies. Additionally, while structural variation (SV) is highly prevalent, PCa genomic studies are still biased towards small variant interrogation
14p viellison 28-03-2024 7 2 Download
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Heart failure continues to be a leading cause of hospitalization worldwide, and acute heart failure (AHF) poses a significant risk of morbidity and mortality in the short term. Acute heart failure (AHF) is a clinical syndrome with different triggering factors and manifests either as new onset or as an acute decompensation of chronic HF.
11p vicwell 06-03-2024 7 2 Download
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Dilated cardiomyopathy (DCM) is a life-threatening heart disease and a common cause of heart failure due to systolic dysfunction and subsequent left or biventricular dilatation. A significant number of cases have a genetic etiology; however, as a complex disease, the exact genetic risk factors are largely unknown, and many patients remain without a molecular diagnosis.
21p vicwell 29-02-2024 5 2 Download
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Ebook "Effective risk communication: A message-centered approach" coordination of risk assessments and risk communication strategies requires information sharing and establishing networks of working relationships between groups and agencies. Establishing these relationships necessitates overcoming - situational, cultural, and political boundaries. Significant barriers exist between regulatory agencies and industry groups.
185p manmanthanhla0201 27-02-2024 3 1 Download
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SERPINC1 is a glycoprotein that regulates blood coagulation. SERPINC1 congenital or acquired deficiencies represent a significant risk factor for thromboembolic disease. SERPINC1 acquired defects are observed in very few cases and can occur in many clinical conditions such as treatment with l-asparaginase or oral contraceptive (particularly estrogen derivatives), but these conditions are not routinely investigated.
3p vitiki 30-01-2024 3 2 Download
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Cancer is a major public health problem with pharmacotherapy being the cornerstone of its management. Cancer patients receive multiple drugs concurrently risking Drug-Drug Interactions (DDIs).
11p vileonardodavinci 23-12-2023 2 2 Download
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Pancreatic adenocarcinoma (PAAD) is a leading cause of cancer-related mortality in adults. Syndecan-4 (SDC4) is involved in cancer pathogenesis. Therefore, this study aimed to explore the expression and clinical significance of SDC4 in PAAD.
10p vialfrednobel 23-12-2023 3 3 Download
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Breast Cancer (BC) is a formidable global health challenge, and Iran is no exception, with BC accounting for a significant proportion of women’s malignancies. To gain deeper insights into the epidemiological characteristics of BC in Iran, this study employs advanced geospatial techniques and feature selection methods to identify significant risk factors and spatial patterns associated with BC incidence.
22p vialfrednobel 23-12-2023 7 3 Download
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There are significant differences in the incidence and risk factors of tumor patients, and there is no relevant statistical data. Therefore, this study aims to clarify the incidence and risk factors of acute kidney injury (AKI) in malignant tumor patients and compare critically ill patients with non-critically ill patients.
14p vialfrednobel 23-12-2023 5 3 Download
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Severe lymphedema presents a challenge in terms of treatment due to the significant formation of scar tissue that accompanies it. The aim of this study was to identify intraoperative and preoperative risk factors of severe lymphedema and to develop a nomogram for estimating the risk of severe lymphedema within 3 years of surgery.
8p vischultz 20-10-2023 4 1 Download