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Single Base Substitutions
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Base substitution catalogues represent historical records of mutational processes that have been active in a cell. Such processes can be distinguished by various characteristics, like mutation type, sequence context, transcriptional and replicative strand bias, genomic distribution and association with (epi)-genomic features.
11p
vibransone
28-03-2024
6
2
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Knowing the activity of the mutational processes shaping a cancer genome may provide insight into tumorigenesis and personalized therapy. It is thus important to characterize the signatures of active mutational processes in patients from their patterns of single base substitutions.
12p
vibransone
28-03-2024
9
2
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The mutational profile of cancer reflects the activity of the mutagenic processes which have been operative throughout the lineage of the cancer cell. These processes leave characteristic profiles of somatic mutations called mutational signatures. Mutational signatures, including single-base substitution (SBS) signatures, may reflect the effects of exogenous or endogenous exposures.
16p
viellison
28-03-2024
8
2
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New ligand based on p-tertbutyltetrathiacalix[4]arene blocked in 1,3-alternate conformation, was achieved via a multistep synthesis with the introduction of thiomethylpropoxy groups on the lower rim which leads to a neutral tecton. The combination of this p-tertbutyltetrathiacalix[4]arene (p-TCA-2), in 1, 3-alternate imposed conformation, with tetrahedral Ag(I)SbF6 salt, leads to the formation of neutral, new 2-D coordination network, which was structurally investigated in the solid state by X-ray diffraction methods on a single crystal.
9p
lyhuyenthu
31-01-2023
5
1
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Pest eradication using the Sterile Insect Technique (SIT) involves high-density releases of sterilized males that mate with wild females and ultimately suppress the population. Sterilized females are not required for SIT and their removal or separation from males prior to release remains challenging.
10p
vihagrid
30-01-2023
9
3
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It is nowadays clear that single base substitutions that occur in the human genome, of which some lead to pathogenic conditions, are non-random and influenced by their flanking nucleobase sequences. However, despite recent progress, the understanding of these "non-local" effects is still far from being achieved.
11p
visilicon2711
20-08-2021
17
1
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Calvin cycle plays a crucial role in carbon fixation which provides the precursors of organic macromolecules for plant growth and development. Currently, no gene involved in Calvin cycle has been identified in monocotyledonous plants through mutant or/and map-based cloning approach.
14p
vijichea2711
28-05-2021
7
1
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Human leukocyte antigen (HLA) genes are critical genes involved in important biomedical aspects, including organ transplantation, autoimmune diseases and infectious diseases. The gene family contains the most polymorphic genes in humans and the difference between two alleles is only a single base pair substitution in many cases.
10p
vikentucky2711
26-11-2020
12
1
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The nature of somatic mutations observed in human tumors at single gene or genome-wide levels can reveal information on past carcinogenic exposures and mutational processes contributing to tumor development.
10p
vioklahoma2711
19-11-2020
9
2
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RNA editing is a co-transcriptional modification that increases the molecular diversity, alters secondary structure and protein coding sequences by changing the sequence of transcripts. The most common RNA editing modification is the single base substitution (A → I) that is catalyzed by the members of the Adenosine deaminases that act on RNA (ADAR) family.
15p
vioklahoma2711
19-11-2020
6
2
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Single Base Substitutions (SBS) that alter transcripts expressed in cancer originate from somatic mutations. However, recent studies report SBS in transcripts that are not supported by the genomic DNA of tumor cells.
13p
vijisoo2711
30-09-2020
7
1
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The development of public-key cryptography is the greatest and perhaps the only true revolution in the entire history of cryptography. From its earliest beginnings to modern times, virtually all cryptographic systems have been based on the elementary tools of substitution and permutation, and can be classed as private/secret/single key (symmetric) systems. All classical, and modern block and stream ciphers are of this form.
66p
koxih_kothogmih3
24-08-2020
30
3
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Present study was conducted with the objectives to identify single nucleotide polymorphism in sperm associated antigen 11 B(SPAG11B) gene and to analyze association between identified polymorphism with conception rate in Murrah bulls in ICAR-National Dairy Research Institute (NDRI) herd, Karnal. A 373 base pair region covering partial intron 2, exon 3 and partial intron3 of bovine SPAG11 gene was amplified using genomic DNA extracted from eighty six Murrah bulls and genotyped using sequencing and polymerase chain reaction- restriction fragment length polymorphisms (PCR-RFLP) methods.
7p
cothumenhmong3
22-02-2020
19
0
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Magnetorheological (MR) brakes, owing to their quick response, are being investigated as a possible candidate for substitution for the conventional hydraulic brakes of road vehicles. The MR brake system for a two-wheeler application was envisaged in this article. Based on analytical equations, the system was modelled in the MATLAB Simulink environment. The braking performance of the system in terms of the stopping distance was estimated with the help of the model. The output from the model was compared with the Indian Standard (IS) automotive brake standard requirement for two-wheelers.
9p
trinhthamhodang1
14-11-2019
17
1
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The present study was carried out with the objective of developing new parental lines of hybrid rice based on chromosome single-segment substitution lines (SSSLs), on which the restorer and maintainer genes Rf3 (rf3) and Rf4 (rf4) were harbored in rice.
6p
vimb123
11-01-2019
15
1
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Current complex-feature based grammars use a single procedure--unification--for a multitude of purposes, among them, enforcing formal agreement between purely syntactic features. This paper presents evidence from several natural languages that unification--variable-matching combined with variable substitution--is the wrong mechanism for effecting agreement. The view of grammar developed here is one in which unification is used for semantic interpretation, while purely formal agreement involves only a check for non-distinctness---i.e, variable-matching without variable substitution. ...
11p
bungio_1
03-05-2013
55
2
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Having thus introduced the papers collectively, let me also say something about them individually, thereby giving some sense for which kinds of economists might find which papers especially interesting. Akerlof and Kranton’s paper has clear links to both labor economics and organizational economics, and also more broadly to behavioral economics.
19p
hoangphiyeah1tv
18-04-2013
55
3
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In this paper a method to incorporate linguistic information regarding single-word and compound verbs is proposed, as a first step towards an SMT model based on linguistically-classified phrases. By substituting these verb structures by the base form of the head verb, we achieve a better statistical word alignment performance, and are able to better estimate the translation model and generalize to unseen verb forms during translation. Preliminary experiments for the English - Spanish language pair are performed, and future research lines are detailed. ...
6p
bunbo_1
17-04-2013
36
1
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Staphylococcalnuclease is a single domain protein with 149 amino acids. It has no disulfide bonds, which makes it a simple model for the study of pro-tein folding. In this study, 20 mutants of this protein were generated each with a single base substitution of glycine for negatively charged glutamic acid or aspartic acid. Using differential scanning microcalorimetry in ther-mal denaturation experiments, we identified two mutants, E75G and E129G, having approximately 43% and 44%, respectively, lowerDHcal values than the wild-type protein....
8p
fptmusic
11-04-2013
38
1
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Staphylococcal nuclease (SNase) is a model protein that contains one domain and no disulfide bonds. Its stability in the native state may be maintained mainly by key amino acids. In this study, two point-mutated proteins each with a single base substitution [alanine for tryptophan (W140A) and alanine for lysine (K133A)] and two truncated fragment proteins {positions 1–139 [SNase(1–139) or W140O] and positions 1–141 [SNase(1–141) or E142O]} were generated.
7p
fptmusic
11-04-2013
37
1
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