Small G protein
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Ebook "Ras superfamily small G proteins: Biology and mechanisms 2 (Transport)" discusses subfamily proteins which function in molecular and vesicular transport mechanisms inside the cell. In this volume the focus lies on the Rab, Ran and Arf subfamily members. As in Volume 1, the book is written by international renowned scientists in the field of small G-proteins. In elaborate reviews, biochemistry, structure, function and G-protein - effector interactions are described. Together with Volume 1 this book provides an comprehensive state-of-the-art work on small G-proteins (GTPases).
299p tracanhphuonghoa1007 22-04-2024 2 2 Download
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Sequencing-based large screening of RNA-protein and RNA-RNA interactions has enabled the mechanistic study of post-transcriptional RNA processing and sorting, including exosome-mediated RNA secretion. The downstream analysis of RNA binding sites has encouraged the investigation of novel sequence motifs, which resulted in exceptional new challenges for identifying motifs from very short sequences (e.g., small non-coding RNAs or truncated messenger RNAs), where conventional methods tend to be ineffective.
17p vibeauty 23-10-2021 10 0 Download
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Transportation of pigment precursors or related metabolites from cytoplasm to subcellular pigment granules is one of the key steps in insect pigmentation and usually executed via such transporter proteins as the ATP-binding cassette (ABC) transmembrane transporters and small G-proteins (e.g. Rab protein).
18p vilichoo2711 23-06-2021 17 1 Download
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Rad is the prototypic member of a subfamily of Ras-related small G-proteins and is highly expressed in the skeletal muscle of patients with type II diabetes. Our previous microarray analysis suggested that Rad may mediate fracture nonunion development.
9p vivermont2711 28-01-2021 7 1 Download
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Proteins often contain regions that are compositionally biased (CB), i.e., they are made from a small subset of amino-acid residue types. These CB regions can be functionally important, e.g., the prion-forming and prion-like regions that are rich in asparagine and glutamine residues.
9p viconnecticut2711 29-10-2020 9 1 Download
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Primary small cell carcinoma of the esophagus (SCCE) is a highly aggressive disease characterized by early dissemination and poor prognosis. Because of the rarity of this disease, few previous studies have investigated the biomarkers associated with its prognosis. Leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) is a stem cell marker and a member of the canonical Wnt-signaling cascade. However, the clinical role of Lgr5 in SCCE remains unknown.
7p virose2711 25-09-2020 15 1 Download
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RhoC is a small G protein/GTPase and involved in tumor mobility, invasion and metastasis. Previously, up-regulated RhoC expression is found to play an important role in ovarian carcinogenesis and subsequent progression by modulating proliferation, apoptosis, migration and invasion.
12p virose2711 22-09-2020 16 2 Download
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The ability to site-specifically conjugate a protein to a payload of interest (e.g., a fluorophore, small molecule pharmacophore, oligonucleotide, or other protein) has found widespread application in basic research and drug development.
11p viuchiha2711 21-04-2020 10 1 Download
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Nitrogen in manure occurs mainly in organic forms (e.g., proteins) and as ammonium (NH4+). Some composted manures contain small amounts of nitrate. Ammonium and nitrate are plant-available forms of N, while organic N is not immediately plant-available. Before organic N can be taken up, however, it must first be converted to inorganic forms. This process, which is completed by soil microbes as a by-product of organic matter decomposition, is called mineralization. The mineralization rate is therefore the rate at which organic N is made plant available.
7p nguaconbaynhay3 07-02-2020 22 0 Download
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The formation of G-quadruplex plays a key role in many biological processes. Therefore, visualization of G-quadruplex is highly essential for design of G-quadruplex-targeted small molecules (drugs). Herein, we report on an engineered fluorescent protein probe which was able to distinguish G-quadruplex topologies.
6p vitheseus2711 29-10-2019 15 0 Download
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Reconstitution of membrane proteins allows their study in a membrane environment that can be manipulated at will. Because membrane proteins have diverse biophysical pro-perties, reconstitution methods have so far been developed for individual proteins on an ad hoc basis. We developed a postinsertion reconstitution method for CCR5, a G protein coupled receptor, with seven transmembraneahelices and small ecto- and endodomains.
12p tumor12 22-04-2013 36 1 Download
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The interaction of heat shock protein with molecular mass 25 kDa (HSP25) and its point mutants S77D + S81D (2D mutant) and S15D + S77D + S81D (3D mutant) with intact and thermally denatured actinwas analyzedbymeans of fluorescence spectroscopy and ultracentrifugation. Wild typeHSP25 did not affect the polymerization of intact actin. The HSP25 3D mutant decreased the initial rate without affecting the maximal extent of intact actin polymerization. G-actin heated at 40–45C was partially denatured, but retained its ability to polymerize....
10p tumor12 20-04-2013 22 2 Download
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The small heat shock proteins function as molecular chaperones, an activ-ity often requiring reversible oligomerization and which protects against irreversible protein denaturation. An abundantly produced small heat shock protein termed p26 is thought to contribute to the remarkable stress resistance exhibited by encysted embryos of the crustacean,Artemia francis-cana. Three novel sequence motifs termed G, R and TS were individually deleted from p26 by site-directed mutagenesis.
14p fptmusic 12-04-2013 43 3 Download
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Recent approaches to text classication have used two dierent rst-order probabilistic models for classication, both of which make the naive Bayes assumption. Some use a multi-variate Bernoulli model, that is, a Bayesian Network with no dependencies between words and binary word features (e.g. Larkey and Croft 1996; Koller and Sahami 1997). Others use a multinomial model, that is, a uni-gram language model with integer word counts (e.g. Lewis and Gale 1994; Mitchell 1997).
8p giamdocamnhac 06-04-2013 50 5 Download
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A small anaerobically induced tomato transcription factor was isolated from a subtractive library. This factor, desig-nated ABZ1 (anaerobic basic leucine zipper), is anaerobi-cally induced in fruits, leaves and roots and encodes a nuclear localized protein. ABZ1 shares close structural and sequence homology with the S-family of small basic leucine zipper (bZIP) transcription factors that are implicated in stress response.Nuclear localizationofABZ1 ismediatedby the basic region and occurs under normoxic conditions. ABZ1 binds to G-box-like target sites as a dimer. ...
11p awards 05-04-2013 37 1 Download
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K-Ras is a small G-protein, localized mainly at the inner leaflet of the plasma membrane. The membrane targeting signal of this protein consists of a polybasic C-terminal sequence of six contiguous lysines and a farnesyl-ated cysteine. Results from biophysical studies in model systems suggest that hydrophobic and electrostatic interactions are responsible for the membrane binding properties of K-Ras.
19p galaxyss3 19-03-2013 42 3 Download
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Prokineticins are a novel family of secreted peptides with diverse regulatory roles, one of which is their capacity to modulate immunity in humans and in other species. Prokineticins are small peptides of 8 kDa that mediate their biological activities by signaling through two homologous G-protein-coupled receptors (prokineticin receptor 1 and prokineticin receptor 2).
8p galaxyss3 07-03-2013 38 2 Download
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The small G protein Rap1 regulates diverse cellular processes such as inte-grin activation, cell adhesion, cell–cell junction formation and cell polarity. It is crucial to identify Rap1 effectors to better understand the signalling pathways controlling these processes.
15p media19 04-03-2013 32 1 Download
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The voltage-gated potassium channel Kv4.3 was coexpressed with itsb-sub-unit Kv channel-interacting protein 2 and the angiotensin type 1 receptor in HEK-293 cells. Proteomic analysis of proteins coimmunoprecipitated with Kv4.3 revealed that Kv4.3 is associated with Rap guanine nucleotide exchange factors MR-GEF and EPAC-1.
10p media19 04-03-2013 34 1 Download
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A food may test positive for glucose but not have enough glucose to taste sweet, or the sweet flavor may be masked, e.g. by a sour flavor. Sweet foods may have little glucose, but significant amounts of other sugars (or artificial sweeteners that bind to taste receptors for sugars). When there is a small amount of a type of molecule (e.g. fat in pretzels) the tests used in this activity may not be sensitive enough to read positive. The results of the protein test for pretzels may be somewhat ambiguous, but if a little bit of pretzel is crushed...
14p cao_can 02-01-2013 40 2 Download