Small lymphocytic lymphoma

High-dose methylprednisolone (HDMP) with or without anti-CD20 antibody treatment in the pre B-cell receptor inhibitor (BCRi) era was used as potential salvage therapy for relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (r/r CLL/SLL) patients bearing the 17p deletion.

7p lazzaro 30-12-2021 8 0   Download

Morphology of Lymphomas: Describe the histologic appearance of typical cases of follicular lymphoma, diffuse large B-cell lymphoma, small lymphocytic lymphoma/ chronic lymphocytic leukemia, and Hodgkin lymphoma.

7p caothientrangnguyen 10-05-2020 11 1   Download

Monoclonal antibody therapies include Herceptin (described left) and Rituxan (rituximab), which has had unparalleled success in treating lymphoma (cancer of the lymph nodes, part of the body’s immune system). Rituximab locks onto a protein called CD20, found on the surface of one of the main types of normal white blood cells (b lymphocytes) 21. CD20 is also present on the surface of most abnormal b lymphocytes associated with most types of non- Hodgkin’s lymphoma.

37p quaivatdo 14-11-2012 37 0   Download

B Cell Chronic Lymphoid Leukemia/Small Lymphocytic Lymphoma: Treatment Patients whose presentation is typical B cell CLL with no manifestations of the disease other than bone marrow involvement and lymphocytosis (i.e., Rai stage O and Binet stage A; Table 105-7) can be followed without specific therapy for their malignancy. These patients have a median survival 10 years, and some will never require therapy for this disorder.

5p thanhongan 07-12-2010 75 3   Download

Table 105-10 Clinical Characteristics of Patients with Common Types of Non-Hodgkin's Lymphomas (NHL) Dis ease edian Age, years M Fre quency in tage S B one B Gastro intestinal Survi Children Male I/II vs Sympt Marro Tract III/IV, oms, % % w Involvement, ving 5 years Involve % ment, % B 6 Rar 9 3 7 3 cell chronic lymphocyt ic leukemia/ small lymphocyt ic lymphoma 5 e 3 vs 91 3 2 1 Ma ntle cell 3 6 e Rar 4 2 0 vs 80 8 2 4 6 9 7 lymphoma Ext ranodal marginal zone cell lymphoma of MALT B 0 6 e Rar 8 6 7 vs 33 9 1 4 1 50 4 type Fol licular lymphoma 9 ...

5p thanhongan 07-12-2010 69 2   Download

Chronic lymphocytic leukemia. The peripheral white blood cell count is high due to increased numbers of small, well-differentiated, normal-appearing lymphocytes. The leukemia lymphocytes are fragile, and substantial numbers of broken, smudged cells are usually also present on the blood smear. If the primary presentation is lymphadenopathy and a lymph node biopsy is performed, pathologists usually have little difficulty in making the diagnosis of small lymphocytic lymphoma based on morphologic findings and immunophenotype.

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Table 79-3 Representative Oncogenes at Chromosomal Translocations Gene (Chromosome) Translocation Malignancy ABL BCR (22q11) (9q34.1)– (9;22)(q34;q11) Chronic myelogenous leukemia ATF1 EWS (22q12) (12q13)– (12;22)(q13;q12) Malignant melanoma of soft parts (MMSP) BCL1 IgH (14q32) (11q13.3)– (11;14)(q13;q32) Mantle lymphoma cell BCL2 IgH (14q32) (18q21.

5p konheokonmummim 03-12-2010 66 3   Download