Small molecules

Leptomeningeal metastasis (LM) of small cell lung cancer (SCLC) is a highly detrimental occurrence associated with severe neurological disorders, lacking effective treatment currently. Proteolysis-targeting chimeric molecules (PROTACs) may provide new therapeutic avenues for treatment of podophyllotoxin derivatives-resistant SCLC with LM, warranting further exploration.

12p vishanshan 27-06-2024 2 1   Download

Transforming growth factor-β (TGF-β) is a cytokine with multiple functions, including cell growth regulation, extracellular matrix production, angiogenesis homeostasis adjustment and et al. TGF-β pathway activation promotes tumor metastasis/progression and mediates epithelial-mesenchymal transmission suppressing immunosurveillance in advanced tumors.

13p vishanshan 27-06-2024 1 1   Download

Molecular targeted therapy using a drug that suppresses the growth and spread of cancer cells via inhibition of a spe‑ cifc protein is a foundation of precision medicine and treatment. High expression of the proto-oncogene Bcl-3 promotes the proliferation and metastasis of cancer cells originating from tissues such as the colon, prostate, breast, and skin.

12p vishanshan 27-06-2024 1 1   Download

This brief describes studies conducted by the authors on mid-size drugs utilizing peptides and peptidomimetics, and on the development of anti-HIV agents. Peptides are important biological molecules and have various physiological actions. Peptide-based drug discovery may help bring about the development of useful medicines that are highly safe and show potent pharmacological effects in small doses.

113p vimeyers 29-05-2024 3 2   Download

Ebook Interpretation of MS–MS mass spectra of drugs and pesticides includes the following main contents: Provides a general discussion on the fragmentation of even-electron ions (protonated and deprotonated molecules) in both positive-ion and negative-ion modes; This is the reference book for the interpretation of MS–MS mass spectra of small organic molecules; Covers related therapeutic classes of compounds such as drugs for cardiovascular diseases, psychotropic compounds, drugs of abuse and designer drugs, antimicrobials, among many others.

405p vimeyers 29-05-2024 4 2   Download

This study focuses on examining the effect of the π bridge on the properties of the molecule. The structural parameters of the molecular geometry were optimized, the HOMO and LUMO energies were calculated and analyzed in detail. In addition, the absorption wavelength, excitation energy, vibration intensity and electron transfer were calculated through the time-dependent density functional theory (TD-DFT) method.

6p dianmotminh02 03-05-2024 4 2   Download

Ebook "Stem cell therapy in lysosomal storage diseases" discusses the history, current practice and future perspectives of stem cells in inborn errors of metabolism (IEM) and provides an international perspective on progress, limitations, and future directions in the field. Beginning with an overview of these diseases, the book covers the breadth of this topic from treatment options, bone marrow transplantation, and alternative treatment options, through long-term outcomes and future perspectives.

178p ladongphongthanh1008 22-04-2024 5 2   Download

Ebook "Targeting protein-protein interactions by small molecules" comprehensively reviews the state-of-the-art strategies developed for protein-protein interaction (PPI) inhibitors, and highlights the success stories in new drug discovery and development. Consisting of two parts with twelve chapters, it demonstrates the design strategies and case studies of small molecule PPI inhibitors. The first part discusses various discovery strategies for small molecule PPI inhibitors, such as high throughput screening, hot spot-based design, computational approaches, and fragment-based design.

332p tracanhphuonghoa1007 22-04-2024 4 2   Download

Ebook "Advancing development of synthetic gene regulators: With the power of high-throughput sequencing in chemical biology" focuses on an “outside the box” notion by utilizing the powerful applications of next-generation sequencing (NGS) technologies in the interface of chemistry and biology. In personalized medicine, developing small molecules targeting a specific genomic sequence is an attractive goal. N-methylpyrrole (P)–N-methylimidazole (I) polyamides (PIPs) are a class of small molecule that can bind to the DNA minor groove.

123p tracanhphuonghoa1007 22-04-2024 4 2   Download

Ebook "Small molecule therapeutics for schizophrenia" covers all relevant aspects of drug research, e.g.

327p tracanhphuonghoa1007 22-04-2024 3 3   Download

Immune checkpoint blockade (ICB) therapy has demonstrated considerable clinical benefit in several malignancies, but has shown favorable response in only a small proportion of cancer patients. Recent studies have shown that matrix metalloproteinases (MMPs) are highly associated with the microenvironment of tumors and immune cells. However, it is unknown whether MMPs are involved in immunotherapy.

19p vibransone 28-03-2024 6 2   Download

Ebook "Modelling the dissociation dynamics and threshold photoelectron spectra of small halogenated molecules" outlines two related experimental techniques, threshold photoelectron spectroscopy and threshold photoelectron photoion coincidence techniques, which are utilised to investigate small halogenated molecules. All the experiments were conducted at the vacuum ultraviolet beamline of the Swiss Light Source, a synchrotron photon source, which has the advantage over popular laser photon-sources of extreme ease of tunability.

184p tudohanhtau1006 29-03-2024 2 1   Download

Ebook "Multiscale modelling of organic and hybrid photovoltaics" presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience.

407p tudohanhtau1006 29-03-2024 3 1   Download

Ebook "Progress in the chemistry of organic natural products (Volume 99)" contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in the field and provides a comprehensive and up-to-date review of the topic in question.

258p tudohanhtau1006 29-03-2024 6 1   Download

Ebook "Correlation force spectroscopy for single molecule measurements" addresses the development of a new force spectroscopy tool, correlation force spectroscopy (CFS) for the measurement of the properties of very small volumes of material (molecular to µm3) at kHz-MHz frequency range. CFS measures the simultaneous thermal fluctuations of two closely-spaced atomic force microscopy (AFM) cantilevers. CFS then calculates the cross-correlation in the thermal fluctuations that gives the mechanical properties of the matter that spans the gap of the two cantilevers.

135p tudohanhtau1006 29-03-2024 5 1   Download

Ebook "Carbon sequestration in agricultural soils: A multidisciplinary approach to innovative methods" reports findings of two methods for soil carbon sequestration related to their application in agricultural field trials. These methods are definitively based on the innovative understanding of soil organic matter chemistry as supramolecular association of small molecules the protection from mineralization of labile soil molecules by the hydrophobic domains present in humified mature compost amended to soils.

316p coduathanh1122 27-03-2024 5 1   Download

Ebook "The electron capture detector and the study of reactions with thermal electrons" describes the general theory and practice of using the Electron Capture Detector (ECD) to study reactions of thermal electrons with molecules. It reviews electron affinities and thermodynamic and kinetic parameters of atoms, small molecules, and large organic molecules obtained by using various methods.

412p coduathanh1122 27-03-2024 5 1   Download

Ebook "Therapy of viral infections (Topics in medicinal chemistry, Volume 15)" focuses on the one hand on recent developments of inhibitors against wellestablished drug targets and on the other hand new targets on either the virus or its host side are presented.

231p manmanthanhla0201 26-02-2024 1 1   Download

Ebook "Introduction to ion beam biotechnology" presents an comprehensive primer on radiation-induced mutations and implantation of charged particles altering biological development. As such, its one of the most intriguing and leading tools in bioengineering cells. IIBB cover the physics of ions particles, the biological effects of ion implantations in cells, and the subsequent use in bacteria, in viruses, and in plants.

303p manmanthanhla0201 27-02-2024 3 1   Download

Ebook "Fortschritte der chemie organischer naturstoffe: Progress in the chemistry of organic natural products" contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in the field and provides a comprehensive and up-to-date review of the topic in question.

169p manmanthanhla0201 27-02-2024 3 1   Download