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Social genomics
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Precision medicine (PM) can be defined as a predictive, preventive, personalized, and participatory healthcare service delivery model. Recent developments in molecular biology and information technology make PM a reality today through the use of massive amounts of genetic, ‘omics’, clinical, environmental, and lifestyle data.
12p
vioraclene
31-03-2024
3
2
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Clinical use of polygenic risk scores (PRS) will look very different to the more familiar monogenic testing. Here we argue that despite these differences, most of the ethical, legal, and social issues (ELSI) raised in the monogenic setting, such as the relevance of results to family members, the approach to secondary and incidental findings, and the role of expert mediators, continue to be relevant in the polygenic context, albeit in modified form.
10p
vibransone
28-03-2024
2
2
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Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by impaired social and communication skills, restricted interests, and repetitive behaviors. The prevalence of ASD among children in Qatar was recently estimated to be 1.1%, though the genetic architecture underlying ASD both in Qatar and the greater Middle East has been largely unexplored.
16p
vicwell
29-02-2024
4
2
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Part 1 book "Handbook of laboratory animal science (Vol 3)" includes content: Animal models of spinal cord injury; animal models for tropical parasitic diseases; animal models of cardiovascular disease; animal models of sudden infant death syndrome; animal models of developmental processes and developmental disorders for social genomics and beyond.
171p
oursky10
07-12-2023
5
3
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Part 2 book "Genetics in medicine" includes content: The molecular basis of genetic disease; the molecular, biochemical, and cellular basis of genetic disease; the treatment of genetic disease; developmental genetics and birth defects; cancer genetics and genomics; risk assessment and genetic counseling; prenatal diagnosis and screening; application of genomics to medicine and personalized health care; ethical and social issues in genetics and genomics.
315p
oursky09
08-11-2023
5
3
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Part 2 book "Shark research - Emerging technologies and applications for the field and laboratory" includes content: Near-Infrared spectroscopy for shark ageing and biology, photographic identifiation of sharks, genetics and genomics for fundamental and applied research on elasmobranchs, social science and its application to the studies of shark biology,... and other contents.
215p
oursky05
20-09-2023
2
2
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The significant social and economic loss as a result of bovine tuberculosis (bTB) presents a continuous challenge to cattle industries in the UK and worldwide. However, host genetic variation in cattle susceptibility to bTB provides an opportunity to select for resistant animals and further understand the genetic mechanisms underlying disease dynamics.
10p
vinarcissa
21-03-2023
3
1
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(BQ) Ebook Brain, behavior and epigenetics: Part 2 presents the following content: Chapter 8: The Strategies of the Genes: Genomic Conflicts, Attachment Theory, and Development of the Social Brain; Chapter 9: Genomic Imprinting Effects on Brain and Behavior: Future Directions; Chapter 10: Epigenetic Influence of the Social Environment; Chapter 11: Toward an Understanding of the Dynamic Interdependence of Genes and Environment in the Regulation of Phenotype; Chapter 12: Histone Deacetylase Inhibitors: A Novel Therapeutic Approach for Cognitive Disorders; Chapter 13: Epigenetic Mechanisms of ...
175p
runordie7
30-08-2022
7
2
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Chronic venous leg ulcers (CVLUs) are the most common type of lower extremity wound. Even when treated with evidenced-based care, 30–50% of CVLUs fail to heal. A specific gap exists about the association between psychosocial stressors, particularly loneliness, and biomarkers of inflammation and immunity.
11p
viisaacnewton
25-04-2022
18
4
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Reproductive division of labor in eusocial insects is a striking example of a shared genetic background giving rise to alternative phenotypes, namely queen and worker castes. Queen and worker phenotypes play major roles in the evolution of eusocial insects. Their behavior, morphology and physiology underpin many ecologically relevant colony-level traits, which evolved in parallel in multiple species.
19p
viaristotle
29-01-2022
19
0
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Network analysis is a powerful way of modeling chromatin interactions. Assortativity is a network property used in social sciences to identify factors affecting how people establish social ties. We propose a new approach, using chromatin assortativity, to integrate the epigenomic landscape of a specific cell type with its chromatin interaction network and thus investigate which proteins or chromatin marks mediate genomic contacts.
19p
viaristotle
29-01-2022
11
0
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The phenotype of an individual can be affected not only by the individual’s own genotypes, known as direct genetic effects (DGE), but also by genotypes of interacting partners, indirect genetic effects (IGE). IGE have been detected using polygenic models in multiple species, including laboratory mice and humans. However, the underlying mechanisms remain largely unknown.
21p
viarchimedes
26-01-2022
16
0
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The evolution of multicellularity is a critical event that remains incompletely understood. We use the social amoeba, Dictyostelium discoideum, one of the rare organisms that readily transits back and forth between both unicellular and multicellular stages, to examine the role of epigenetics in regulating multicellularity.
30p
viarchimedes
26-01-2022
12
0
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Japanese cedar (Cryptomeria japonica) is an important tree for Japanese forestry. Male-sterile marker development in Japanese cedar would facilitate selection of male-sterile plus trees, addressing the widespread social problem of pollinosis and facilitating the identification of heterozygotes, which are useful for breeding.
16p
vibeauty
23-10-2021
4
0
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Meiotic recombination is a fundamental genetic process that shuffles allele combinations and promotes accurate segregation of chromosomes. Analyses of the ubiquitous variation of recombination rates within and across species suggest that recombination is evolving adaptively. All studied insects with advanced eusociality have shown exceptionally high recombination rates, which may represent a prominent case of adaptive evolution of recombination.
12p
vitzuyu2711
29-09-2021
8
1
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Understanding the underlying genetic structure of human populations is of fundamental interest to both biological and social sciences. Advances in high-throughput genotyping technology have markedly improved our understanding of global patterns of human genetic variation. The most widely used methods for collecting variant information at the DNA-level include whole genome sequencing, which remains costly, and the more economical solution of array-based techniques, as these are capable of simultaneously genotyping a pre-selected set of variable DNA sites in the human genome.
13p
vitzuyu2711
29-09-2021
14
1
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Similar to other urban trees, holm oaks (Quercus ilex L.) provide a physiological, ecological and social service in the urban environment, since they remove atmospheric pollution. However, the urban environment has several abiotic factors that negatively influence plant life, which are further exacerbated due to climate change, especially in the Mediterranean area.
18p
vitzuyu2711
29-09-2021
7
1
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The honeybee (Apis mellifera) represents a model organism for social insects displaying behavioral plasticity. This is reflected by an age-dependent task allocation. The most protruding tasks are performed by young nurse bees and older forager bees that take care of the brood inside the hive and collect food from outside the hive, respectively.
15p
vigiselle2711
30-08-2021
5
1
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Successful social behavior requires real-time integration of information about the environment, internal physiology, and past experience. The molecular substrates of this integration are poorly understood, but likely modulate neural plasticity and gene regulation.
27p
visilicon2711
20-08-2021
10
1
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Foraging behavior in honey bees (Apis mellifera) is a complex phenotype that is regulated by physiological state and social signals. How these factors are integrated at the molecular level to modulate foraging behavior has not been well characterized.
15p
visilicon2711
20-08-2021
5
1
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