Specialized medicine

The core list presents a list of minimum medicine needs for a basic health‐care system, listing the most efficacious, safe and cost‐effective medicines for priority conditions. Priority conditions are selected on the basis of current and estimated future public health relevance, and potential for safe and cost‐effective treatment. The complementary list presents essential medicines for priority diseases, for which specialized diagnostic or monitoring facilities, and/or specialist medical care, and/or specialist training are needed.

45p kikyou751998 23-05-2012 444 38   Download

Intracranial infection (abscess) - usually staphylococci or streptococci. Cranial surgery performed to open and drain abscess. Epilepsy - Cranial surgery to remove the epileptic focus for patients whose epilepsy cannot be controlled by drug therapy. Skull fractures - for depressed fracture or fracture with loose fragments. Cranial surgery necessary to elevate depressed bone and/or remove fragments.

38p littledragon89 10-08-2011 95 23   Download

Lectures Musculoskeletal Care for the General Doctor: Shoulder and Knee Pain presented the history, causes of discrimination by age, location of pain and the other history factors, the legal test visit clinical examination, initial treatment, ... This is a useful reference for readers and researchers studying their specialized medicine.

59p tuoihaimuoi32 17-06-2014 63 4   Download

Practical questions put forward by clinicians in the past have been researched and settled in the thesis. The AD diagnosis is completely based on clinics and the implementation of clinical tests for the diagnosis work depends on assessors’ subjectivity. Therefore, the development of MRI techniques shall help clinicians make diagnosis more quickly and objectively.

27p closefriend09 16-11-2021 31 4   Download

Study the clinical characteristics, endoscopy, histopathology, expression of proteins p53, Ki67, Her- 2/neu in colorectal cancer and colorectal polyps greater than or equal to 10 mm; study the relationship between the expression of proteins p53, Ki67 and Her- 2/neu with histopathological characteristics, lymph node metastasis in colorectal cancer and colorectal polyps greater than or equal to 10 mm.

27p change04 08-06-2016 52 4   Download

Department of Medical Biochemistry and Biology, University of Bari, Italy; 2Department of Zoology, Laboratory of Histology and Comparative Anatomy, University of Bari, Italy; 3Center for the Study of Mitochondria and Energy Metabolism (CNR) Bari, Italy Mitochondrial bioenergetic impairment has been found in the organelles isolated from rat liver during the prereplicative phase of liver regeneration.

9p system191 01-06-2013 35 4   Download

Telomerase is a specialized reverse transcriptase responsible for synthesizing telomeric DNA at the ends of chromosomes. Six subunits composing the telomerase complex have been cloned: hTR (human telomerase RNA), TEP1 (telomerase-associated protein 1), hTERT (human telomerase reverse transcriptase), hsp90 (heat shock protein 90), p23, and dyskerin. In this study, we investigated the role of each the telomerase subunit on the activity of telomerase.

9p research12 01-06-2013 28 3   Download

The organization of DNA within eukaryotic cell nuclei poses special problems and opportunities for the cell. For example, assembly of DNA into chromatin is thought to be a principle mechanism by which adventitious general transcription is repressed. However, access to genomic DNA for events such as DNA repair must be facilitated by energy-intensive processes that either directly alter chromatin structure or impart post-translational modifications, leading to increased DNA accessibility.

6p research12 01-06-2013 36 4   Download

The centromere–kinetochore complex is a highly specialized chromatin domain that both mediates and monitors chromosome–spindle interactions responsible for accurate partitioning of sister chromatids to daughter cells. Centromeres are distinguished from adjacent chromatin by specific patterns of histone modification and the presence of a centromere-specific histone H3 variant (e.g. CENP-A). Centromere-proximal regions usually correspond to sites of avid and persistent sister chromatid cohesion mediated by the conserved cohesin complex.

15p research12 01-06-2013 49 4   Download

Special oligonucleotides for targeted gene correction have attracted increasing attention recently, one of which is the chimericRNAÆDNAoligonucleotide (RDO) system. RDOs for targeted gene correction were first designed in 1996, and are typically 68 nucleotides in length including continuous RNA andDNA sequences (RNA is 2¢-O-methyl-modified).

6p tumor12 22-04-2013 34 2   Download

Tip growth is a specialized type of polar growth where new cell wall is deposited in a localized region of the cell, the growing tip. These cells show a characteristic zonation, with a high accumulationof secretory vesicles containing cell wall components at the tip, followed by an organelle-enriched zone.MsPG3is a Medicago sativapolygalacturonase gene isolated in our laboratory, specifically expressed during the interaction of this plant with its symbiotic partner Sinorhiz-obium melilotiand which might participate in tip growth processes during symbiosis....

9p tumor12 20-04-2013 41 3   Download

The peptide hormone endothelin transmits various signals throughGprotein-coupled receptors, the endothelin type A (ETAR) and B (ETBR) receptors. Caveolae are specialized lipid rafts containing polymerized caveolins. We examined the interaction of ETBR with caveolin-1, expressed in Sf9, COS-1, and HEK293 cells, and its effects on the subcellular distribution and the signal transduction of ETBR.

12p fptmusic 16-04-2013 27 2   Download

One of the hallmarks of cAMP is its ability to inhibit proliferation in many cell types, but stimulate proliferation in others. Clearly cAMP has cell type specific effects and the outcome on proliferation is largely attributed to crosstalk from cAMP to the RAS⁄RAF⁄mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) kinase (MEK)/ ERK pathway. We review the crosstalk between these two ancient and con-served pathways, describing the molecular mechanisms underlying the interactions between these pathways and discussing their possible biological importance....

14p fptmusic 11-04-2013 41 3   Download

Nociceptors are specialized nerve fibers that transmit noxious pain stimuli to the dorsal horn of the spinal cord. A subset of nociceptors, the nonpepti-dergic C-fibers, is characterized by its reactivity for the plant isolectin B4 (IB4) from Griffonia simplicifolia. The molecular nature of the IB4-reactive glycoconjugate, although used as a neuroanatomical marker for more than a decade, has remained unknown.

13p awards 05-04-2013 35 4   Download

It is now generally accepted that factor XII (FXII) binds to cellular surfaces in the vascular system. One of the suggested receptors of this binding is the glycosylphosphatidylinositol-anchored urokinase-like plasminogen activator (u-PAR) harbored in caveolae/lipid rafts. However, binding of FXII to human umbilical vein endothelial cells (HUVEC) has never been shown to be localized to these specialized mem-brane structures. Using microscopical techniques, we here report that FXII binds to specific patches of the HUVEC plasma membrane with a high density of caveolae....

8p awards 05-04-2013 44 6   Download

We have used the circular dichroismand infrared spectra of a specially designed 50 protein database [Oberg, K.A., Ruysschaert, J.M. & Goormaghtigh, E. (2003)Protein Sci. 12, 2015–2031] in order to optimize the accuracy of spectroscopic protein secondary structure determination using multivariate statisticalanalysis methods. The results demonstrate that when the proteins are carefully selected for the diversity in their structure, no smaller subset of the database contains the necessary information to describe the entire set....

12p awards 05-04-2013 39 4   Download

The nematocyst capsules of the cnidarians are specialized explosive organelles that withstand high osmotic pressures of
15 MPa (150 bar). A tight disulfide network involving cysteine-rich capsule wall proteins, like minicollagens and nematocyst outer wall antigen, characterizes their molecular composition.

8p inspiron33 25-03-2013 43 3   Download

We have investigated the direct effect of arachidonic acid on cholesterol transport in intact cells or isolated mitochondria from steroidogenic cells and the effect of cyclic-AMP on the specific release of this fatty acid inside the mitochondria. We show for the first time that cyclic-AMP can regulate the release of arachidonic acid in a specialized compartment of MA-10 Leydig cells, e.g.

11p inspiron33 23-03-2013 35 5   Download

Cell survival depends not only on the ability to repair damaged DNA but also on the capability to perform DNA replication on unrepaired or imperfect templates. Crucial to this process are specialized DNA polym-erases belonging to the Y family. These enzymes share a similar catalytic fold in their N-terminal region, and most of them have a less-well-con-served C-terminus which is not required for catalytic activity.

11p galaxyss3 19-03-2013 36 3   Download

Vitamin B6 is one of the most important compounds in living organisms, and its biosynthesis has only recently been understood. Because it is required for more than 100 biochemical reactions, lack of the vitamin is fatal. This is of special importance to mammals and humans, which cannot biosynthesize the vitamin and thus depend on its external uptake. Here we describe the cloning of a vitamin B6 biosynthetic gene GbPDX1from Ginkgo biloba.

10p media19 06-03-2013 34 1   Download