Specific antiviral therapy

Part 1 book "Nelson’s pediatric antimicrobial therapy" includes content: Antimicrobial therapy according to clinical syndromes; antimicrobial therapy for neonates; preferred therapy for specific bacterial and mycobacterial pathogens; preferred therapy for specific viral pathogens, choosing among antiviral agents... and other contents.

204p oursky03 28-08-2023 3 1   Download

Dengue is still a recurrent challenge to the global population, without specific antiviral therapy. Clinical management strategies are aimed to mitigate the deaths. The use of blood products in dengue is recommended mainly in cases of bleeding.

10p videadpool 05-05-2023 4 2   Download

Etravirine (ETV) was approved as the second generation drug for use in individuals infected with HIV-1 in 2008 by the U.S. FDA with its unique antiviral activity, high specificity, and low toxicity. However, there are some shortcomings of the existing synthetic routes, such as the long reaction time and poor yield.

6p vijiraiya2711 27-05-2020 8 1   Download

Chronic hepatitis C virus (HCV) infection is a main health problem in Egypt causing high rates of mortalities. Egypt has the highest HCV prevalence in the world, with specific HCV subtypes epidemic and circulating extensively in the country. Different antiviral therapy protocols have been implemented for treating Egyptian HCV patients. Due to the limited data about HCV in Egypt, this study aimed to genotype HCV strains circulating in the Nile Delta Damietta governorate and to investigate the variation in the nonstructural 5B (NS5B) region targeted by the newly approved antiviral drugs.

9p trinhthamhodang1 14-11-2019 12 0   Download

Most chronic hepatitis B (CHB) patients in China are primitively treated with a combination of lamivudine (LAM) and adefovir dipivoxil (ADV). Although antiviral resistance can be avoided with this combination therapy, using it can have harmful side effects related to ADV, specifically kidney and bone injury.

6p vinasaki2711 12-11-2019 8 0   Download

However, a recent study of Moriwaki and al [1] found ultrasound was 85% sensitive and 100% specific for detection of free air in a prospective study of 484 patients. Some small studies have also investigated the utility of ultrasound contrast agents to detect active bleeding [2]. Ultrasound is relatively sensitive for free abdominal fluid. In a study, continuous scanning of Morison’s pouch during infusion of DPL fluid revealed a mean detection limit of 619 mL.

298p kmkmkmkmkm 10-09-2012 59 3   Download

The field of antiviral therapy—both the number of antiviral drugs and our understanding of their optimal use—continues to lag behind the field of antibacterial drug treatment, in which 70 years of experience have now been accumulated, but significant progress has been made in recent years on new drugs for several viral infections. The development of antiviral drugs poses several challenges. Viruses replicate intracellularly and often employ host cell enzymes, macromolecules, and organelles for synthesis of viral particles.

34p crazy_sms 09-05-2012 49 2   Download

THERAPY AND PROPHYLAXIS A few antiviral drugs are available for clinical use in special therapeutic and prophylactic situations. Immunoglobulins and vaccines have been prepared for prophylaxis against a considerable number of virus infections. LABORATORY DIAGNOSIS Virus, viral antigen or viral genome may be detected in the early phase of acute disease by electron microscopy, immunological or molecular biological methods or virus isolation. Serologically the diagnosis can be made by demonstration of seroconversion, antibody titre rise or specific IgM....

281p ozon_ozon 04-05-2012 62 13   Download