Specific populations

Recent studies have demonstrated that accelerated enhanced recovery after colorectal surgery is feasible for specific patient populations. The accelerated enhanced recovery protocols (ERP) tend to vary, and the majority of studies included a small study population. This hampers defining the optimal protocol and establishing the potential benefits.

15p vishanshan 27-06-2024 2 1   Download

Taxanes appear to be safe following the first trimester of pregnancy, with obstetric and fetal outcomes being similar to those observed in the general obstetric population. Future studies should aim to determine the most effective taxane regimen and dosage for use during gestation, with a specific focus on treatment safety.

8p vishanshan 27-06-2024 1 1   Download

Adolescents and young adults (AYAs) with cancer, defined as individuals aged 15–39 years at initial cancer diagnosis, form a unique population; they face age-specific issues as they transition to adulthood. This paper presents the protocol for the development of a core outcome set (COS) for AYAs with cancer

12p vishanshan 27-06-2024 1 1   Download

Inflammation, malnutrition, and cancer are intricately interconnected. Despite this, only a few studies have delved into the relationship between inflammatory malnutrition and the risk of death among cancer survivors. This study aimed to specifically investigate the association between the categorically defined Naples prognostic score (NPS) and the prognosis of cancer survivors.

12p vikoch 27-06-2024 0 0   Download

In study "Impact of urbanization on seawater quality in Quang Ninh province" the authors use indicators to assess the level of water pollution, such as chemical and microbial pollution and measure the impact of urban factors, such as population growth, wastewater discharge and water consumption. In the survey results of seawater quality in two seasons, the rainy season and the dry season, there is a difference in some specific hydrological indicators, such as Coliform exceeding the allowable threshold in the dry season and iron and ammonium content tending to increase.

11p tukhauquantuong1011 22-04-2024 3 2   Download

Alzheimer’s disease (AD) is characterized by neuronal loss and astrocytosis in the cerebral cortex. However, the specific effects that pathological mutations and coding variants associated with AD have on the cellular composition of the brain are often ignored.

19p vibransone 28-03-2024 3 2   Download

Chlamydia trachomatis (Ct) is the most common infectious cause of blindness and bacterial sexually transmitted infection worldwide. Ct strain-specific differences in clinical trachoma suggest that genetic polymorphisms in Ct may contribute to the observed variability in severity of clinical disease.

19p vibransone 28-03-2024 3 2   Download

Distinct prevalence of inherited genetic predisposition may partially explain the difference of cancer risks across ancestries. Ancestry-specific analyses of germline genomes are required to inform cancer genetic risk and prognosis of diverse populations.

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Genome-wide association studies are useful for discovering genotype–phenotype associations but are limited because they require large cohorts to identify a signal, which can be population-specific. Mapping genetic variation to genes improves power and allows the effects of both protein-coding variation as well as variation in expression to be combined into “gene level” effects.

9p vioraclene 31-03-2024 3 2   Download

Limited treatment options are available for patients infected with multidrug (MDR)- or pan-drug (PDR)- resistant bacterial pathogens, resulting in infections that can persist for weeks or months. In order to better understand transmission and evolutionary dynamics of MDR Acinetobacter baumannii (Ab) during long-term infection, we analyzed genomes from a series of isolates from individual patients at isolate-specific, patient-specific, and population levels.

12p vioraclene 31-03-2024 3 2   Download

Preclinical studies require models that recapitulate the cellular diversity of human tumors and provide insight into the drug sensitivities of specific cellular populations. The ideal platform would enable rapid screening of cell type-specific drug sensitivities directly in patient tumor tissue and reveal strategies to overcome intratumoral heterogeneity.

15p vibransone 28-03-2024 3 2   Download

We present Beyondcell, a computational methodology for identifying tumour cell subpopulations with distinct drug responses in single-cell RNA-seq data and proposing cancer-specific treatments. Our method calculates an enrichment score in a collection of drug signatures, delineating therapeutic clusters (TCs) within cellular populations.

15p vibransone 28-03-2024 2 1   Download

Here, we report a lack of diversity in epigenome-wide association studies (EWAS) and DNA methylation (DNAm) data, discuss current challenges, and propose solutions for EWAS and DNAm research in diverse populations. The strategies we propose include fostering community involvement, new data generation, and cost-effective approaches such as locus-specific analysis and ancestry variable region analysis.

4p viellison 28-03-2024 5 2   Download

The goal of this study is to quantify the health-economic impacts of PM2.5 pollution for a specific province - Long An province in Vietnam using the EnHEBIS (Environment, Public Health, and Economic Benefit Management Support Integrated System) software package. The study outcomes showed that significant health and economic effects could occur in areas with high PM2.5 concentrations and dense population concentrations.

15p viellison 28-03-2024 2 1   Download

Asthma is the most common chronic disease in children, occurring at higher frequencies and with more severe disease in children with African ancestry. Previously unknown genetic variation at the 17q12-21 childhood-onset asthma locus contributes to asthma severity in individuals with African ancestries. We suggest that many other population-specific variants that have not been discovered in GWAS contribute to the genetic risk for asthma and other common diseases.

16p viellison 28-03-2024 2 2   Download

Born from multidisciplinary roots that include logistics, marketing, management, and sociology, SCM has developed into a distinct field of study over the past fifty years. SCM theory has only recently reached a state of maturation where it produces operationalisable concepts and tools, but progress is being made in advancing both the overarching field of SCM and the specific issues that fall under the SCM umbrella. The authors investigated supply chain strategy as an active longevity’s policy and quality of life of elderly population in the Russian Federation.

8p longtimenosee04 06-03-2024 2 0   Download

In ebook "Conceptual ecology and invasion biology: Reciprocal approaches to nature" global experts in ecology and evolutionary biology explore how theories in ecology elucidate the invasion processes while also examining how specific invasions informs ecological theory. This reciprocal benefit is highlighted in a number of scales of organization: population, community and biogeographic, while employing example invaders in all major groups of organisms and from a number of regions around the globe.

506p tachieuhoa 28-01-2024 4 2   Download

Part 2 book "Veterinary immunology" includes content: Immunity to bacteria and fungi, immunity to viruses, immunity to parasites, type I hypersensitivity, red cell antigens and type ii hypersensitivity, immune complexes and type III, hypersensitivity, type IV hypersensitivity; organ graft rejection; resistance to tumors; autoimmunity; organ specific autoimmune diseases; systemic immunological diseases; primary immunodeficiencies; secondary immunological defects; drugs and other agents that affect the immune system,...and other contents.

291p muasambanhan03 02-01-2024 5 2   Download

Dealing with uncertainty is one of the critical topics in health technology assessment. The greater decision uncertainty in appraisals, the less clear the clinical- and cost-effectiveness of the health technology. Although the development of targeted cancer therapies (TCTs) has improved patient health care, additional complexity has been introduced in drug appraisals due to targeting more specific populations.

15p vileonardodavinci 23-12-2023 3 2   Download

A national colorectal cancer (CRC) screening programme was launched in 2002 in Germany. A comprehensive evaluation of the programme effectiveness using real-world data is still lacking. In addition, there are regional reports on increasing colorectal cancer incidence in younger populations.

15p vileonardodavinci 23-12-2023 3 2   Download