Specific toxicities

Ebook "Water treatment technologies for the removal of high-toxicity pollutants" process requires interdisciplinary approach; it is critically important to stimulate interactions between medical doctors, chemists, physicist, materials scientists, engineers and policy makers, which are already experienced in their specific areas. It is also our ethical obligation to preserve existing water resources and existing eco systems enhancing their biodiversity.

338p giangdongdinh 28-05-2024 1 1   Download

This study aimed to assess the acute and subchronic toxicity of Pyridostigmine bromide 90 mg extended-release tablets in experimental animals. Subjects and methods: Pyridostigmine bromide 90 mg extended-release tablets were prepared complying in-house specifications. Acute oral toxicity (LD50) was determined in white mice using the Litchfield-Wilcoxon method. Subchronic toxicity was assessed in rabbits following OECD guidelines.

5p viohoyo 02-04-2024 5 2   Download

Ebook "Protein modelling" detailed description of cutting-edge computational methods applied to protein modeling as well as specific applications are presented. Chapters include: the application of Car-Parrinello techniques to enzyme mechanisms, the outline and application of QM/MM methods, polarizable force fields, recent methods of ligand docking, molecular dynamics related to NMR spectroscopy, computer optimization of absorption, distribution, metabolism and excretion extended by toxicity for drugs, enzyme design and bioinformatics applied to protein structure prediction.

332p tudohanhtau1006 29-03-2024 2 1   Download

Part 2 book "Nutraceuticals in veterinary medicine" includes content: Nutraceuticals in organ and system disorders; nutraceuticals in specific animal species; safety and toxicity evaluation of nutraceuticals and functional foods; newer trends in nutraceutical research and product development; regulatory aspects and country specific requirements for nutraceuticals.

380p muasambanhan06 03-02-2024 14 1   Download

Part 2 book "Rebhun’s diseases of dairy cattle" includes content: Diseases of the teats and udder; reproductive diseases; diseases specific to or common in dairy bulls; urinary tract diseases; musculoskeletal disorders; neurologic diseases; ocular diseases; metabolic diseases; miscellaneous infectious diseases; toxicities, poisonings, and deficiencies; diagnostic laboratory sample submission.

452p muasambanhan04 07-01-2024 8 1   Download

Toxic phthalates that can be released from food packaging into food are currently a matter of concern, affecting consumers’ health. However, in Vietnam, no studies have been published on this group of substances in food packaging and films.

10p viwhitewolf 11-07-2023 5 4   Download

Muscarinic agonists are indicated for the treatment of many conditions including ileus, urinary retention, glaucoma, and Sjögren’s syndrome. Due to their lack of tissue specificity, these drugs can lead to undesirable side effects at of-target sites and may be potentiated by supplements that impact the half-life of these drugs.

4p vigamora 23-05-2023 3 2   Download

Acid soil is a serious limitation to crop production all over the world. Toxic aluminium (Al) cations in acid soil inhibit root growth and reduce yield. Although a gene tolerant to acid soil has been identified, it has not been used in malting barley breeding, which is partly due to the acid soil tolerance gene being linked to unfavorable malting quality traits.

11p vinarcissa 21-03-2023 4 1   Download

In the current study, the effect of USP7 on pluripotency maintenance of mouse ESCs (mESCs) has been investigated with the help of cell viability assay, morphological analysis, alkaline phosphatase (ALP) staining, qPCR analysis, and Western Blotting. 600 nM P5091 application, which showed no significant toxicity in mESCs, increased the total ubiquitinated protein amount as a proof of the accomplishment of proper USP7 inhibition.

14p lyhuyenthu 31-01-2023 8 3   Download

Though it is toxic to humans, dichlorvos is a widely used chemical pesticide and plays an important role in the control of plant pests. The application of a combination of the biocontrol agent Trichoderma with dichlorvos may reduce the need for chemical pesticides. Therefore, revealing the specific molecular mechanism of Trichoderma tolerance to dichlorvos has become particularly important.

12p vitzuyu2711 29-09-2021 8 1   Download

Zebrafish is a popular animal model used for high-throughput screening of chemical hazards, however, investigations of transcriptomic mechanisms of toxicity are still needed. Here, our goal was to identify genes and biological pathways that Aryl Hydrocarbon Receptor 2 (AHR2) Activators and flame retardant chemicals (FRCs) alter in developing zebrafish.

20p vitzuyu2711 29-09-2021 4 1   Download

Cytochrome P450-dependent monooxygenases (P450s), constituting one of the largest and oldest gene superfamilies found in many organisms from bacteria to humans, play a vital role in the detoxification and inactivation of endogenous toxic compounds.

23p visilicon2711 20-08-2021 9 1   Download

A significant mechanism of salt-tolerance in rice is the ability to remove Na+ and Cl− in the leaf sheath, which limits the entry of these toxic ions into the leaf blade. The leaf sheath removes Na+ mainly in the basal parts, and Cl− mainly in the apical parts.

13p vijichea2711 28-05-2021 7 1   Download

Lead (Pb) is a harmful pollutant that disrupts normal functions from the cell to organ levels. Salix babylonica is characterized by high biomass productivity, high transpiration rates, and species specific Pb. Better understanding the accumulating and transporting Pb capability in shoots and roots of S. babylonica, the toxic effects of Pb and the subcellular distribution of Pb is very important.

15p vijichea2711 28-05-2021 5 1   Download

NipahVirus (NiV) is a zoonotic Virus which infects several animals and humans worldwide. Currently, there is no specific drug or vaccine to treat or control NiV infections. The present study is aimed to identify novel inhibitors of NiV from Indian medicinal plants. Glycoprotein was taken as target protein. Around 600 phytocompounds were taken from 10 Indian medicinal plants and subjected to Virtual Screening by using Libdock module from Discovery Studio 4.0. From these, the best 20 compounds were screened and evaluated for their Pharmacokinetic properties by using ADMETSAR and pKCSM tools.

14p trinhthamhodang9 16-12-2020 9 2   Download

Aberrantly activated Notch signaling has been found in more than 50% of patients with T-cell acute lymphoblastic leukemia (T-ALL). Current strategies that employ γ-secretase inhibitors (GSIs) to target Notch activation have not been successful. Many limitations, such as non-Notch specificity, dose-limiting gastrointestinal toxicity and GSI resistance, have prompted an urgent need for more effective Notch signaling inhibitors for T-ALL treatment.

13p virose2711 22-09-2020 17 2   Download

Multiple myeloma is an incurable cancer with a rising incidence globally. Less toxic treatments are increasingly available, so patients are living longer and treatment decisions are increasingly guided by QOL concerns. There is no QOL assessment tool designed specifically for use in the clinical care of people with myeloma.

12p vialabama2711 21-09-2020 13 0   Download

Dietary selenium supplementation in the poultry has been regularly practiced using the inorganic and organic forms to enhance the growth and antioxidant defence system. These forms have the limitations of having narrow margin of safety and non specific binding to tissue proteins, hence an alternate form of selenium i.e. nano selenium having greater potential as poultry and livestock feed supplement with higher bioavailability, higher margin of safety and seven fold lower acute toxicity was prepared using starch, ascorbic acid and bovine serum albumin.

8p trinhthamhodang7 31-08-2020 11 1   Download

Comorbidity increases overall mortality in patients diagnosed with hematological malignancies. The impact of comorbidity on cancer-specific mortality, taking competing risks into account, has not been evaluated.

12p vimoscow2711 29-08-2020 10 0   Download

The anti-tumour activity of cisplatin is thought to be a result of its capacity to form DNA adducts which prevent cellular processes such as DNA replication and transcription. These DNA adducts can effectively induce cancer cell death, however, there are a range of clinical side effects and drug resistance issues associated with its use.

17p vinaypyidaw2711 26-08-2020 16 1   Download