Specific treatment indication
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Monitoring treatment and early detection of fatal breast cancer (BC) remains a major unmet need. Aberrant circulating DNA methylation (DNAme) patterns are likely to provide a highly specific cancer signal. We hypothesized that cell-free DNAme markers could indicate disseminated breast cancer, even in the presence of substantial quantities of background DNA.
11p vioraclene 31-03-2024 5 2 Download
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Despite a myriad of attempts in the last three decades to diagnose ovarian cancer (OC) earlier, this clinical aim still remains a significant challenge. Aberrant methylation patterns of linked CpGs analyzed in DNA fragments shed by cancers into the bloodstream (i.e. cell-free DNA) can provide highly specific signals indicating cancer presence.
14p vioraclene 31-03-2024 3 1 Download
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This specification covers hot-finished and cold-finished martensitic chromium steel bars for high-temperature service. The mechanical properties are developed by suitable heat treatment, as indicated for each alloy.
4p hth_hn_vn 10-12-2023 5 3 Download
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Precision oncology, defined as treatment of patients with targeted therapies matched to specific molecular alterations, has entered routine clinical practice. Particularly in patients with advanced cancer or hemato‑ logic malignancies, for whom no further standard therapies are available, this approach is increasingly applied as last resort option outside of the approved indication.
7p visharma 20-10-2023 4 2 Download
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Muscarinic agonists are indicated for the treatment of many conditions including ileus, urinary retention, glaucoma, and Sjögren’s syndrome. Due to their lack of tissue specificity, these drugs can lead to undesirable side effects at of-target sites and may be potentiated by supplements that impact the half-life of these drugs.
4p vigamora 23-05-2023 3 2 Download
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Prognostic indicators, treatments, and survival estimates vary by cancer type. Therefore, disease-specific models are needed to estimate patient survival. Our primary aim was to develop models to estimate survival duration after treatment for skeletal-related events (SREs) (symptomatic bone metastasis, including impending or actual pathologic fractures) in men with metastatic bone disease due to prostate cancer.
11p vikolindagrabar 27-07-2022 3 1 Download
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It is unknown whether and to what degree trials submitted to the US FDA to support drug approval adhere to NCCN guideline-recommended care in their baseline and surveillance CNS imaging protocols. Objective: We sought to characterize the frequency with which the trials cited in US FDA drug approvals for first line advanced NSCLC between 2015 and 2020 deviated from NCCN guideline-recommended care for baseline and surveillance CNS imaging.
8p vielonmusk 21-01-2022 11 0 Download
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Pathogenesis-related proteins (PR-proteins) are induced in response to environmental stresses such as osmotic and drought stress, wounding, microbial infections and treatment with specific plant hormones and elicitors. These proteins are classified into several groups (PR-1 through PR-17) based on their amino acid sequence and biochemical functions. The present study focuses on prediction, isolation, over-expression and analysis of the antifungal activities of the thaumatin-like proteins (i.e. PR-5) in the model legume M. truncatula var. truncatula. Analysis of M.
12p thiencuuchu 27-11-2021 7 1 Download
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The treatments comprised of pre harvest spraying of various nutrients and bagging with different colours of polythene to study various physico quality of rainy season guava.
11p caygaocaolon8 07-11-2020 5 1 Download
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Over the last decades numerous initiatives have been set up that aim at translating the best available medical knowledge and treatment into clinical practice. The inherent complexity of the programs and discrepancies in the terminology used make it difficult to appreciate each of them distinctly and compare their specific strengths and weaknesses.
9p vimanama2711 30-07-2020 10 2 Download
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The screening of thirty-two tomato genotypes for drought stress tolerance was done under pot culture conditions in polyhouse where drought stress was imposed at 15 days after transplanting based on two treatments viz., 100 per cent field capacity and 50 per cent field capacity by adopting factorial completely randomized block design with three replications.
11p angicungduoc6 20-07-2020 12 2 Download
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The catalyst 7.5% NiO/TiO2 and seven samples of NiO/γ-Al2O3 with NiO content from 7.5% to 60% have been obtained and studied. Physico-chemical characteristics of the catalysts were determined by methods of Adsorption (BET), X-ray Diffraction (XRD), TemperatureProgrammed Reduction (TPR) and Hydrogen Pulse Titration. The catalytic properties of the obtained samples were investigated in the reaction of CO methanation at temperatures 180 – 220◦C and mole ratios hydrogen/carbon monoxide 25-100.
16p 12120609 01-06-2020 5 0 Download
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Ombitasvir/paritaprevir/ritonavir/dasabuvir (Viekira Pak®) are the newest medicines approved for use in the treatment of hepatitis C virus (HCV) and are available in tablet form as an oral combination. Specifically, these agents are indicated in the treatment of HCV in patients with genotype 1 infection.
8p vijiraiya2711 27-05-2020 12 0 Download
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The experiment was taken up at Horticultural Research station, Orissa University of Agriculture and Technology, Bhubaneswar, Orissa during Rabi season for the year 2013 & 2014. 500 seeds of variety Utkal Kumari (BT-10) were taken and subjected to single and combined mutagenic treatment as per the specification. Seedlings of the fifteen treatments were transplanted following Randomised Block Design (RBD) with three replications. Leaf area (dm2 /plant), Total Dry matter and chlorophyll content were measured 30, 60 and 75 days of transplanting.
6p nguathienthan4 18-04-2020 7 0 Download
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Eight native strains of Pseudomonas spp. were isolated from rhizosphere of various sugarcane clones on Pseudomonas agar using standard protocols. These strains were characterized for antagonistic traits on red rot pathogen in vitro and Plant growthpromoting (PGP) activities in greenhouse up to 30 days from single node setts in portrays as sett treatment (@109 CFU ml-1 ). The promising isolate was characterized up to species level by PCR amplification of 16S rDNA region using Pseudomonas specific primers. Elite strain was identified as P. putida strain AKP-1.
9p kethamoi4 16-04-2020 8 1 Download
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Neonatal sepsis is a clinical syndrome of bacteremia characterized by systemic signs and symptoms of infection in the first month of life. It has been a challenge with its high incidence and grave prognosis, despite adequate treatment with modern antibiotics. The signs and symptoms are protean with a high mortality and thus there is urgent need to know whether the baby has sepsis. Confirmation of the diagnosis by definitive culture is not rapidly possible.
10p trinhthamhodang4 22-03-2020 33 0 Download
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The experiment was conducted in Post Graduate Laboratory, Department of Genetics and Plant Breeding, Sam Higg in bottom University of Agriculture, Technology and Sciences, Pryagraj (U.P.) during kharif season 2018, in order to standardize the best method of priming specific to Maize (var. HQPM-5). Four methods of priming viz., hydropriming, magnetopriming, halopriming, and organic priming with control (Unprimed) were evaluated by screening different duration (30, 60, 90, 120 minutes and 12 hours) and different concentrations (50 mt, 100 mt, 2% and 5%) viz.
9p cothumenhmong3 22-02-2020 13 1 Download
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The use of Plant Growth Regulators (PGRs) has opened up fresh opportunities for enhanced seed production in pulses in particular which are often face limitations due to intrinsic and external factors. Therefore, an experiment was carried out inside the net house in cement moulded pots to determine the effect of crop growth regulators viz. Maleic Hydrazide, Gibberellin, Triacontanol, 2,3,5- triiodobenzoic acid and Cycocel, as foliar spray. The result indicated significant variations in foliage, canopy structure, floral initiation, pod setting, seeds per plants etc.
6p trinhthamhodang3 12-02-2020 14 0 Download
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An experiment was conducted at Horticulture Garden, Department of Horticulture, Chandra Shekhar Azad University of Agriculture & Technology, Kanpur during the Kharif season of 2016-2017. The experiment was laid out in Randomized Block Design with ten treatments in three replication consist of three levels of each growth regulator i.e. GA3 at 10, 20, 30 ppm, NAA at 20, 30, 40 ppm and 2,4-D at 2.5, 5.0, 7.5 ppm. Maximum plant height (96.18 cm), maximum number of primary and secondary branches, and maximum fruit per plant (46.06), fruit yield per plant (1320.
7p nguaconbaynhay1 04-12-2019 21 1 Download
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Field data verified by green house experiment were used to evaluate the response of Anastatica hierochuntica L. to the amount of rainfall. Field study of the populations was carried out in the runnel and depression microhabitats of gravel and sand sites. Four water treatments, equivalent to 100, 200, 500 and 1000 mm rainfall, were used to simulate different levels of water availability. Under 500 and 1000 mm rainfall, the size-class structure of A.
10p kethamoi1 20-11-2019 13 0 Download