Sphingomyelin

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Báo cáo khoa học: Effects of sphingomyelin, cholesterol and zinc ions on the binding, insertion and aggregation of the amyloid Ab1)40 peptide in solid-supported lipid bilayers

We utilized plasmon-waveguide resonance (PWR) spectroscopy to follow the effects of sphingomyelin, cholesterol and zinc ions on the binding and aggregation of the amyloidbpeptide1)40 in lipid bilayers. With a dioleoyl-phosphatidylcholine (DOPC) bilayer, peptide binding was observed, but no aggregation occurred over a period of 15 h.

14p inspiron33 26-03-2013 45 5 Download

Báo cáo khoa học: The equinatoxin N-terminus is transferred across planar lipid membranes and helps to stabilize the transmembrane pore

Equinatoxin II is a cytolytic protein isolated from the sea anemoneActi-nia equina. It is a member of the actinoporins, a family of eukaryotic pore-forming toxins with a unique mechanism of pore formation. Equinatoxin II is a 20 kDa cysteineless protein, with sphingomyelin-dependent activity. Recent studies showed that the N-terminal region of the molecule requires conformational flexibility during pore formation.

12p inspiron33 23-03-2013 43 5 Download

Báo cáo khoa học: An X-ray diffraction study of model membrane raft structures

$Báo cáo khoa học: An X-ray diffraction study of model membrane raft structures$

Protein sorting and assembly in membrane biogenesis and function involves the creation of ordered domains of lipids known as membrane rafts. The rafts are comprised of all the major classes of lipids, including glycero-phospholipids, sphingolipids and sterol. Cholesterol is known to interact with sphingomyelin to form a liquid-ordered bilayer phase.

14p viettel02 19-02-2013 40 2 Download
Báo cáo khoa hoc : Membrane interaction of Pasteurella multocida toxin involves sphingomyelin

Pasteurella multocidatoxin (PMT) is an AB toxin that causes pleiotropic effects in targeted host cells. The N-terminus of PMT (PMT-N) is consid-ered to harbor the membrane receptor binding and translocation domains responsible for mediating cellular entry and delivery of the C-terminal catalytic domain into the host cytosol.

16p cosis54 09-12-2012 38 5 Download
Choline

Choline Choline là một dưỡng chất thiết yếu trong sinh tổng hợp acetylcholine – một chất dẫn truyền thần kinh quan trọng, và là thành phần chính yếu trong màng tế bào của chúng ta, ví dụ như phosphatidylcholine (lecithin) và sphingomyelin. Choline rất cần thiết cho chuyển hóa mỡ. Không có choline, mỡ bị bắt giữ và tích tụ nhiều ở gan. Mặc dù choline có thể được tổng hợp trong cơ thể từ amino acid methionine hay serine nhưng việc cung cấp qua chế phẩm dinh dưỡng là hết sức cần thiết.[1,2] Choline có nhiều trong lúa gạo, các loại...

5p doremonmap 09-08-2010 166 25 Download