Steroid hormone receptors
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Part 1 book "Regulation of implantation and establishment of pregnancy in mammals" includes content: Introduction, history of maternal recognition of pregnancy, the role of steroid hormone receptors in the establishment of pregnancy in rodents, transmembrane mucin expression and function in embryo implantation and placentation, reflections on rodent implantation, the role of progesterone in maternal recognition of pregnancy in domestic ruminants, implantation and establishment of pregnancy in ruminants.
140p muasambanhan01 11-12-2023 7 2 Download
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Various studies have shown that the insulin-like peptides present in insects and investigation of their possible effects on insect physiology have significance for clarifying the evolutionary developmental period of insulin. The insect fat body is an organ analog to vertebrate adipose tissue and liver. In insects which do not have feeding activity during pupal and adult stages such as Bombyx mori, substances and energy required for continuation of life and development of tissues and organs are provided by the fat body via the autophagy process.
10p dolomite36 30-12-2021 17 0 Download
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There is partially conflicting evidence on the influence of the steroid hormones estrogen (E) and progesterone (P) on the development of ovarian cancer (OC). The aim of this study was to assess the expression of the receptor isoforms ER-α/-β and PR-A/-B in OC tissue and to analyze its impact on clinical and pathological features and patient outcome.
9p vijisoo2711 30-09-2020 13 0 Download
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After the failure of a non-steroidal aromatase inhibitor (nsAI) for postmenopausal patients with metastatic breast cancer (mBC), it is unclear which of various kinds of endocrine therapy is the most appropriate. A randomized controlled trial was performed to compare the efficacy and safety of daily toremifene 120 mg (TOR120), a selective estrogen receptor modulator, and exemestane 25 mg (EXE), a steroidal aromatase inhibitor.
9p vijennie2711 29-09-2020 10 1 Download
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Alternate transcripts from a single gene locus greatly enhance the combinatorial flexibility of the human transcriptome. Different patterns of exon usage have been observed when comparing normal tissue to cancers, suggesting that variant transcripts may play a role in the tumor phenotype.
13p viamsterdam 18-09-2020 10 1 Download
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The development of androgen resistance is a major limitation to androgen deprivation treatment in prostate cancer. We have developed an in vitro model of androgen-resistance to characterise molecular changes occurring as androgen resistance evolves over time.
14p vimoscow2711 29-08-2020 9 0 Download
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The relationship between non-steroidal anti-inflammatory drug (NSAID) consumption and breast cancer has been repeatedly studied, although the results remain controversial. Most case-control studies reported that NSAID consumption protected against breast cancer, while most cohort studies did not find this effect.
11p vimale2711 25-08-2020 10 1 Download
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Indole-3-carbinol, derived from Cruciferous vegetables is an estrogen receptor antagonist considered a preventive agent that is naturally present in diet. There are no previous studies on its effects in human inflammatory breast cancer or canine inflammatory mammary cancer that is the most aggressive type of breast cancer.
9p vibaku2711 22-07-2020 14 2 Download
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Combining cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors with endocrine therapy is an effective strategy to improve progression-free survival in hormone receptor-positive (HR+), human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer.
7p vimanila2711 25-06-2020 15 0 Download
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Male breast cancer (MBC) is rare, accounting for only around 1% of all breast cancers. Most MBCs are hormone-driven. Not only the estrogen receptor (ER), but also other steroid hormone receptors, including the androgen receptor (AR) and progesterone receptor (PgR) are expressed in MBC.
6p viputrajaya2711 22-06-2020 12 0 Download
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Ecdysteroids are hormones with an important role in the molting, reproduction and immunological defense of arthropods. Ecdysone Receptor (EcR) is a protein that belongs to the superfamily of nuclear receptors, widely studied for pesticide discovery. Currently, several non-steroidal molecules, belonging to the chemical group of diacilhydrazines (DAH), are commercially available for pest control. Such molecules are specific for lepidopteran or coleopteran pests. Hemipterans are important pests in most crops and many cases of pesticide resistance are reported.
10p chauchaungayxua1 04-12-2019 14 1 Download
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Gprotein-coupled receptor 30 (GPR30) has previously been described tobe important in steroid-mediatedgrowthand to inhibit cell proliferation. Here we investigated whether the effect of GPR30 on cell growth is dependent on steroid hormone receptors. We stably introduced GPR30 in immortalizednormalmammaryepithelial (HME) cellsusing retroviruses for gene delivery. GPR30 inhibited the growth and proliferation of the cells. They expressed glucocorticoid receptor, but not estrogen or progesterone receptor....
10p awards 05-04-2013 43 4 Download
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Nongenomic action of an insect steroid hormone, 20-hy-droxyecdysone (20E), has been implicated in several 20E-dependent events including the programmed cell death of Bombyxanterior silk glands (ASGs), but no information is available for themodeof theaction.Weprovide evidence for a putative membrane receptor located in the plasma mem-brane of the ASGs. Membrane fractions prepared from the ASGs exhibit high binding activity to [ 3 H]ponasterone A (PonA).
9p awards 05-04-2013 39 3 Download
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The steroid hormone 20-hydroxyecdysone (20E) initiates insect molting and metamorphosis through binding with a heterodimer of two nuclear recep-tors, the ecdysone receptor (EcR) and ultraspiracle (USP). Expression of the specific isoforms EcR-A and EcR-B1 governs steroid-induced responses in the developing cells of the silkworm Bombyx mori.
8p inspiron33 25-03-2013 44 3 Download
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CYP7B1, a cytochrome P450 enzyme, metabolizes several steroids involved in hormonal signaling including 5a-androstane-3b,17b-diol (3b-Adiol), an estrogen receptor agonist, and dehydroepiandrosterone, a precursor for sex hormones. Previous studies have suggested that CYP7B1-dependent metab-olism involving dehydroepiandrosterone or 3b-Adiol may play an impor-tant role for estrogen receptor b-mediated signaling.
12p media19 06-03-2013 40 1 Download
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Nur77 is one member of the nuclear receptor superfamily. As a transcrip-tion factor, Nur77 participates in a variety of biological processes, includ-ing T cell development, inflammatory responses, steroid hormone synthesis, and hepatic glucose metabolism. It typically acts via binding to the Nur77 responsive element (NBRE) in the promoter regions of its target genes.
14p media19 06-03-2013 46 2 Download
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101. Cấu trúc của hormone là những: A. Protein B. Dẫn xuất của acid amine C. Steroid D. A,B,C đều đúng E. A,B,C đều sai. 102. Hormone chỉ có tác dụng khi được gắn với: A. AMP vòng B. Receptor C. ADN D. Adenyl cyclase E. Proteinkinase 103.Adrenalin sau khi gắn vào receptor có tác dụng hoạt hoá trực tiếp: A. ATP B. Adenyl cyclase C. Proteinkinase D. Phosphorylase E. Glycogen synthetase
10p m310dy1ndark 05-03-2013 112 15 Download
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17b-Hydroxysteroid dehydrogenase type 11 (17b-HSD11) is a member of the short-chain dehydrogenase⁄reductase family involved in the activation and inactivation of sex steroid hormones. We recently identified 17b-HSD11 as a gene that is efficiently regulated by peroxisome prolifera-tor-activated receptor-aPPARain the intestine and the liver [Motojima K (2004) Eur J Biochem271, 4141–4146].
11p media19 04-03-2013 14 1 Download
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The molting process in arthropods is regulated by steroid hormones acting via nuclear receptor proteins. The most common molting hormone is the ecdysteroid, 20-hydroxyecdysone. The receptors of 20-hydroxyecdysone have also been identified in many arthropod species, and the amino acid sequences determined.
30p viettel02 20-02-2013 34 3 Download
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Steroid hormone receptors are important drug targets and have been the focus of basic and applied research for decades. Steroid hormone receptors act as ligand-dependent transcription factors. Upon ligand binding, the receptors bind to hormone responsive cis-acting DNA elements (HREs) in the nucleus and regulate the expression of target genes by recruiting chromatin-modifying activities that either promote or deny access to the basal transcription machinery.
211p hyperion75 18-01-2013 47 4 Download