Stress enhancement

Photoelasticity images of pulsed laser ablation in water and in air were simulated by Finite Element Method. In the paper "Compare transient stress induced in in-air and in-water laser ablation using simulation method", the Von Mises stress distribution in the target is deduced from the simulated images and is compared between the two-ablation regimes. The result confirms that pulse laser ablation in the water can induced a stress about 100 times higher than that induced in ablation in the air.

4p xuanphongdacy09 29-09-2024 5 1   Download

The fatigue failure around rail-end-bolt holes is particularly dangerous since it leads to derailment of trains and consequently to inevitable accidents. It is well-known that the fatigue life of structural holed components, subjected to cyclic load, can be increased by generating compressive hoop stresses around the holes.

18p tohitohi 19-05-2020 17 1   Download

Hsp105aisoneof themajormammalianheat shockproteins that belongs to the HSP105/110 family, and is expressed at especially high levels in the brain as compared with other tissues in mammals. Previously, we showed that Hsp105a prevents stress-induced apoptosis in neuronal PC12 cells, and is a novel anti-apoptotic neuroprotective factor in the mammalian brain.

9p research12 23-04-2013 47 1   Download

Exposure of mammalian cells to oxidant stress causes early (iron catalysed) lysosomal rupture followed by apoptosis or necrosis. Enhanced intracellular production of reactive oxygen species (ROS), presumably of mitochondrial origin, is also observed when cells are exposed to nonoxidant pro-apoptotic agonists of cell death. We hypothesized that ROS generation in this latter case might promote the apoptotic cascade and could arise from effects of released lysosomal materials on mitochondria.

9p tumor12 20-04-2013 34 1   Download

Induction of CYP3A genes by the ligand-activated preg-nane-X-receptor (PXR)involves the interaction of other as yet unidentified liver transcription factors. Here we show that the CYP3A1promoter contains two active sites con-trolled by the CCAAT/enhancer-binding protein a (C/ EBPa), previously shown to regulate a number of liver stress response genes. We have identified two functional C/EBP binding sites at theCYP3A1promoter that confer luciferase activity to C/EBPacotransfected CHO cells.

9p tumor12 20-04-2013 46 4   Download

Oxidative stress and imbalance between free radical generation and detoxi-fication may play a pivotal role in the pathogenesis of Leber’s hereditary optic neuropathy (LHON). Mitochondria, carrying the homoplasmic 11778⁄ND4, 3460⁄ND1 and 14484⁄ND6 mtDNA point mutations associ-ated with LHON, were used to generate osteosarcoma-derived cybrids. Enhanced mitochondrial production of reactive oxygen species has recently been demonstrated in these cybrids [Beretta S, Mattavelli L, Sala G, Trem-olizzo L, Schapira AHV, Martinuzzi A, Carelli V & Ferrarese C (2004) Brain127, 2183–2192]. ...

0p awards 05-04-2013 46 4   Download

Plasma concentrations of free fatty acids are increased in metabolic syn-drome, and the increased fatty acids may cause cellular damage via the induction of oxidative stress. The present study was designed to determine whether the increase in fatty acids can modify the free sulfhydryl group in position 34 of albumin (Cys34) and enhance the redox-cycling activity of the copper–albumin complex in high-fat diet-induced obese mice.

9p galaxyss3 21-03-2013 41 3   Download

The mechanisms underlying increased cardioprotection in younger female mice are unclear. We hypothesized that serine-threonine protein kinase (protein kinase B; Akt) triggers a metabolic gene switch (decreased fatty acids, increased glucose) in female hearts to enhance mitochondrial bio-energetic capacity, conferring protection against oxidative stress.

7p media19 04-03-2013 22 3   Download

We reported earlier that ectopic expression of CAP2, a single AP2 domain containing transcription activator from chickpea (Cicer arietinum)in tobacco improves growth and development, and tolerance to dehydration and salt stress, of the transgenic plants.

11p vinaphone15 25-02-2013 39 2   Download

Phagocytosis represents a mechanism used by macrophages to remove pathogens and cellular debris. Recent evidence suggests that phagocytosis is stimulated under specific conditions of stress, such as extracellular pres-sure and hypoxia.

14p viettel02 22-02-2013 19 3   Download

Bacterial RNases are promising tools for the development of anticancer drugs. Neoplastic transformation leads to enhanced accumulation of rRNA and tRNA, and altered expression of regulatory noncoding RNAs. Cleav-age of RNA in cancer cells is the main reason for the cytotoxic effects of exogenic RNases.

12p mobifone23 18-01-2013 59 6   Download

TheOryza sativalectin, abbreviated Orysata, is a mannose-specific, jacalin-related lectin expressed in rice plants after exposure to certain stress condi-tions. Expression of a fusion construct containing the rice lectin sequence linked to enhanced green fluorescent protein in Bright Yellow 2 tobacco cells revealed that Orysata is located in the nucleus and the cytoplasm of the plant cell, indicating that it belongs to the class of nucleocytoplasmic jacalin-related lectins.

16p cosis54 05-01-2013 55 6   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Hyperosmotic stress enhances cytokine production and decreases phagocytosis in vitro...

8p coxanh_3 27-10-2011 41 3   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Enhancing versus Suppressive Effects of Stress on Immune Function: Implications for Immunoprotection versus Immunopathology...

10p thulanh10 09-10-2011 56 5   Download