Subcellular location
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Apoptosis is associated with some human diseases, including cancer, autoimmune disease, neurodegenerative disease and ischemic damage, etc. Apoptosis proteins subcellular localization information is very important for understanding the mechanism of programmed cell death and the development of drugs. Therefore, the prediction of subcellular localization of apoptosis protein is still a challenging task.
17p vibeauty 23-10-2021 16 1 Download
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In plants, Calcium (Ca2+) acts as a universal messenger in various signal transduction pathways, including responses to biotic and abiotic stresses and regulation of cellular and developmental processes. The Ca2+/ cation antiporter (CaCA) superfamily proteins play vital roles in the transport of Ca2+ and/or other cations.
19p vijeeni2711 24-07-2021 4 0 Download
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Biological functions of biomolecules rely on the cellular compartments where they are located in cells. Importantly, RNAs are assigned in specific locations of a cell, enabling the cell to implement diverse biochemical processes in the way of concurrency.
14p vilichoo2711 25-06-2021 11 1 Download
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Proteins perform their functions in associated cellular locations. Therefore, the study of protein function can be facilitated by predictions of protein location. Protein location can be predicted either from the sequence of a protein alone by identification of targeting peptide sequences and motifs, or by homology to proteins of known location.
13p viwyoming2711 16-12-2020 9 1 Download
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Predicting protein subcellular localization is indispensable for inferring protein functions. Recent studies have been focusing on predicting not only single-location proteins, but also multi-location proteins. Almost all of the high performing predictors proposed recently use gene ontology (GO) terms to construct feature vectors for classification.
17p vioklahoma2711 19-11-2020 6 1 Download
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New bioimaging techniques capable of visualising the co-location of numerous proteins within individual cells have been proposed to study tumour heterogeneity of neighbouring cells within the same tissue specimen. These techniques have highlighted the need to better understand the interplay between proteins in terms of their colocalisation.
24p vioklahoma2711 19-11-2020 9 1 Download
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The subcellular localization of a protein is an important aspect of its function. However, the experimental annotation of locations is not even complete for well-studied model organisms. Text mining might aid database curators to add experimental annotations from the scientific literature.
11p viconnecticut2711 28-10-2020 10 1 Download
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Clustering molecular network is a typical method in system biology, which is effective in predicting protein complexes or functional modules. However, few studies have realized that biological molecules are spatial-temporally regulated to form a dynamic cellular network and only a subset of interactions take place at the same location in cells.
9p vicoachella2711 27-10-2020 13 0 Download
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: Protein biomarkers play important roles in cancer diagnosis. Many efforts have been made on measuring abnormal expression intensity in biological samples to identity cancer types and stages. However, the change of subcellular location of proteins, which is also critical for understanding and detecting diseases, has been rarely studied.
15p vicolorado2711 22-10-2020 11 1 Download
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Apoptosis, also called programmed cell death, refers to the spontaneous and orderly death of cells controlled by genes in order to maintain a stable internal environment. Identifying the subcellular location of apoptosis proteins is very helpful in understanding the mechanism of apoptosis and designing drugs.
19p vicolorado2711 22-10-2020 26 0 Download
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TIPE3 (TNFAIP8L3), a transfer protein for lipid second messengers, is upregulated in human lung cancer tissues. The most popular lung cancer is non-small cell lung cancer (NSCLC) with high incidences and low survival rates, while the roles of TIPE3 in NSCLC remain largely unknown.
10p vibaku2711 22-07-2020 8 1 Download
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Plant ALDH10 enzymes are aminoaldehyde dehydrogenases (AMADHs) that oxidize different ω-amino or trimethylammonium aldehydes, but only some of them have betaine aldehyde dehydrogenase (BADH) activity and produce the osmoprotectant glycine betaine (GB).
16p viminato2711 22-05-2020 9 0 Download
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Long non-coding (lnc) RNAs are a class of functional RNA molecules greater than 200 nucleotides in length, and lncRNAs play important roles in various biological regulatory processes and response to the biotic and abiotic stresses.
16p viharuno2711 21-04-2020 14 1 Download
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ING1 has regulatory roles in the expression of genes associated with proliferation, apoptosis, and senescence. p33(ING1b) is the most widely expressed isoform of the gene.
8p nutifooddau 27-01-2019 36 1 Download
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The eukaryotic glyoxylate cycle has been previously hypothesized to occur in the peroxisomal compartment, which in the yeast Saccharomyces cerevisiae additionally represents the sole site for fatty acid b-oxidation. The subcellular location of the key glyoxylate-cycle enzyme malate synthase 1 (Mls1p), an SKL-terminated protein, was examined in yeast cells grown on dierent carbon sources.
8p research12 01-06-2013 38 3 Download
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Glycosphingolipids are located in cell membranes and the brain is especi-ally enriched. We speculated that the subcellular location of glycosphingo-lipids depends on their fatty acid chain length because their sugar residues are constant, whereas fatty acid chain length can vary within the same molecule.
9p inspiron33 26-03-2013 41 4 Download
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Covalent modifications of proteins often modulate their biological func-tions or change their subcellular location. Among the many known protein modifications, three are exceptional in that they only occur on single pro-teins: ethanolamine phosphoglycerol, diphthamide and hypusine.
12p cosis54 04-01-2013 26 3 Download