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Substrate specificity
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This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and cellular transport processes of Clostridium botulinum neurotoxins, Clostridium botulinum C3 toxin, Clostridium difficile toxins, binary clostridial enterotoxins, anthrax toxins and diphtheria toxin.
261p
vimeyers
29-05-2024
5
1
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In this study, the TiO2 passive layer was formed on a pure titanium substrate by simple oxidation in an aqueous solution of H2O2 35 wt.%. In order to determine the appropriate time for the oxidation of the pure titanium substrate, the corrosion rate of the metal in the solution of H2O2 was investigated. The electrochemical behaviour of the TiO2 passive layer on the Ti substrate was investigated in Hank’s solution at 37.5°C.
8p
dianmotminh02
03-05-2024
3
1
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Ebook Using mass spectrometry for biochemical studies on enzymatic domains from polyketide synthases
Ebook "Using mass spectrometry for biochemical studies on enzymatic domains from polyketide synthases" reports studies on the substrate specificity of crucial KS domains from trans-AT PKSs. Using a combination of electrospray ionisation-mass spectrometry (ESI-MS) and simple N-acetyl cysteamine (SNAC) substrate mimics, the substrate specificity of a range of KS domains from the bacillaene (BaeJ and BaeL) and psymberin (PsyA and PsyD) PKSs,...
189p
tracanhphuonghoa1007
22-04-2024
6
3
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Ebook "Homogeneous gold catalysis (Topics in Current chemistry, Volume 357)" begins with a chapter by Malhotra, Hammond, and Xu, which highlights the interplay of ligand effects, substrate structure and mechanism in gold catalysis, using specific examples of ligand design and reactions mediated by gold–oxonium intermediates.
292p
tudohanhtau1006
29-03-2024
5
1
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X-ray photoelectron spectroscopy (XPS) is a well known tool in studying the physical and chemical properties of surface/interfaces which provides the element specific, non-destructive and quantitative information. In the present study, information about the surface chemical states of interfacial structure of CoFe thin films on n-Si substrates has been studied from XPS technique.
5p
viberbers
09-08-2023
5
3
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This work is dealing with the use of polystyrene (PS) nanoparticles as substrates for bioanalytical specific interactions. Different techniques were used for the accurate characterization of the PS nanoparticles of 100 nm and 196 nm before coating them with a layer of antibodies against immunoglobulins of type E (aIgE).
11p
viginny
23-12-2022
12
3
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Recently, several non-classical functions of histone modification regulators (HMRs), independent of their known histone modification substrates and products, have been reported to be essential for specific cellular processes. However, there is no framework designed for identifying such functions systematically.
16p
viarchimedes
26-01-2022
18
1
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In this study, the ethanol degradation ability of the catalyst, which was added with 0; 0.5; 1, and 1.5% liquid glass and calcined at 400 and 500 oC, was determined. TiO2 nanotubes after preparation have a uniform diameter from 10-12 nm and an average length of about 150nm, specific surface area increases markedly compared to commercial granules (nearly 15 times).
10p
meyerowitz
25-12-2021
9
0
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The purpose of this study was to determine the temperature and pH stability and lipase specific substrate from microbes that grow on coconut pulp media.
7p
chauchaungayxua12
29-07-2021
9
1
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The study aimed at the utilization of locally available feed resources for increasing growth performance and reducing enteric methane emissions from goats in Lao PDR.
34p
nguathienthan12
23-05-2021
26
2
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This study was aimed to customise enzymes specific for tapioca flour a common choice of the farmers here in Puducherry for the cereal source of the ruminant diet.
7p
caygaocaolon11
21-04-2021
6
1
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Mixed cultures of different microbial species are increasingly being used to carry out a specific biochemical function in lieu of engineering a single microbe to do the same task. However, knowing how different species’ metabolisms will integrate to reach a desired outcome is a difficult problem that has been studied in great detail using steady-state models.
12p
vioklahoma2711
19-11-2020
19
2
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Isotopic tracer analysis by mass spectrometry is a core technique for the study of metabolism. Isotopically labeled atoms from substrates, such as [13C]-labeled glucose, can be traced by their incorporation over time into specific metabolic products. Mass spectrometry is often used for the detection and differentiation of the isotopologues of each metabolite of interest.
8p
vioklahoma2711
19-11-2020
34
1
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The mechanism of action of proteases has been widely studied based on substrate specificity. Prior research has been focused on the amino acids at a single amino acid site, but rarely on combinations of amino acids around the cleavage bond.
9p
viflorida2711
30-10-2020
16
2
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Eqolisins are rare acid proteases found in archaea, bacteria and fungi. Certain fungi secrete acids as part of their lifestyle and interestingly these also have many eqolisin paralogs, up to nine paralogs have been recorded.
16p
viconnecticut2711
28-10-2020
11
1
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Membrane androgen receptors (mAR) are functionally expressed in a variety of tumor-cells including the breast tumor-cell line MCF-7. They are specifically activated by testosterone albumin conjugates (TAC). The mAR sensitive signaling includes activation of Ras-related C3 botulinum toxin substrate 1 (Rac1) and reorganization of the actin filament network.
10p
vimoscow2711
29-08-2020
14
1
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MEK1 (MAP2K1) and MEK2 (MAP2K2) are closely related dual-specificity protein kinases which function by phosphorylating both serine/threonine and tyrosine residues of their substrates ERK1 and ERK2, controlling fundamental cellular processes that include cell growth and proliferation.
8p
vimale2711
25-08-2020
15
2
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Cytomegalovirus infections are endemic worldwide. The most frequently used methods for detecting antibodies in developing world are the Enzyme Linked Immunosorbent Assay. The polymerase chain reaction is a molecular biology technique in which the production of large amounts of specific deoxyribonucleic acid fragments is induced from very low concentrations of complex substrates allowing the detection of very low amounts of viral particles.
6p
nguathienthan5
04-06-2020
8
1
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This paper reviews the existing literature on green roof benefits and performance and specifically focuses on their potential to address climate change issues.
16p
kelseynguyen
28-05-2020
10
1
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Plant ALDH10 enzymes are aminoaldehyde dehydrogenases (AMADHs) that oxidize different ω-amino or trimethylammonium aldehydes, but only some of them have betaine aldehyde dehydrogenase (BADH) activity and produce the osmoprotectant glycine betaine (GB).
16p
viminato2711
22-05-2020
9
0
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