Survival regression models
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This study sought to investigate the prognostic value of basement membrane (BM)-associated gene expressions in oral cancer. Methods We harvested and integrated data on BM-associated genes (BMGs), the oral cancer transcriptome, and clinical information from public repositories. After identifying differentially expressed BMGs, we used Cox and Lasso regression analyses to create a BMG-based risk score for overall survival at various intervals.
15p vikoch 27-06-2024 3 1 Download
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Part 2 book "Biostatistics - A methodology for the health sciences" includes content: Association and prediction - multiple regression analysis and linear models with multiple predictor variables; multiple comparisons; discrimination and classification; principal component analysis and factor analysis; rates and proportions; analysis of the time to an event - survival analysis; sample sizes for observational studies; longitudinal data analysis; randomized clinical trials; personal postscript.
453p muasambanhan06 03-02-2024 6 1 Download
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Hepatocellular carcinoma (HCC) is a major health concern, necessitating a deeper understanding of its prognosis and underlying mechanisms. This study aimed to investigate the mechanism and prognostic value of CD8+T Cell exhaustion (CD8+TEX)-related genes in HCC and construct a survival prognosis prediction model for patients with HCC.
15p vileonardodavinci 23-12-2023 3 3 Download
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Prediction of patient survival from tumor molecular ‘-omics’ data is a key step toward personalized medicine. Cox models performed on RNA profiling datasets are popular for clinical outcome predictions. But these models are applied in the context of “high dimension”, as the number p of covariates (gene expressions) greatly exceeds the number n of patients and e of events.
16p vialfrednobel 23-12-2023 3 3 Download
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Recent studies have shown that deficient mismatch repair (dMMR) rectal cancer may be related to treatment resistance, resulting in a worse prognosis than proficient MMR (pMMR) rectal cancer. The purpose of this study was to explore whether surgery plus other treatments (radiotherapy and chemotherapy) can bring more benefits to these patients than surgery alone.
11p vialfrednobel 23-12-2023 5 3 Download
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Diagnosis and treatment of diffuse malignant peritoneal mesothelioma (DMPM) are still challenging. The aim of the present study was to explore the correlation between CD74, CD10, Ki-67 and clinicopathological parameters, and identify independent prognostic factors of DMPM.
13p visharma 20-10-2023 3 2 Download
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Early initiation of breastfeeding is one of the most simple and essential intervention for child development and survival in the world. World Health Organization recommended to begin breast milk with one hour after delivery. The objective of this study was to determine the magnitude of early initiation of breastfeeding in Sub-Saharan Africa using DHS data set.
10p viferrari 28-11-2022 7 2 Download
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Several studies have identified factors influencing infant mortality, but, to the best of knowledge, no studies assessed the factors considering unequal effects on different survival times of infant mortality in Bangladesh. In this study, it was examined how a set of covariate behaves on different quantile survival times related with the infant mortality.
9p viferrari 29-10-2022 2 2 Download
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Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in North America. Previous studies have shown improved progression free survival (PFS) and response rates in unfit patients treated with obinutuzumab compared to other regimens.
11p vikolindagrabar 27-07-2022 3 1 Download
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We collected information on patients with rectal adenocarcinoma in the United States from the Surveillance, Epidemiology, and EndResults (SEER) database. We used this information to establish a model that combined deep learning with a multilayer neural network (the DeepSurv model) for predicting the survival rate of patients with rectal adenocarcinoma.
14p vipriyankagandhi 27-07-2022 5 2 Download
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Despite the tremendous therapeutic advances that have stemmed from somatic oncogenetics, survival of some cancers has not improved in 50 years. Osteosarcoma still has a 5-year survival rate of 66%. We propose the natural canine osteosarcoma model can change that: it is extremely similar to the human condition, except for being highly heritable and having a dramatically higher incidence.
14p visilicon2711 20-08-2021 8 1 Download
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The role of surgery for the primary tumor in breast cancer patients with bone metastases (BM) remains unclear. The purpose of this study was to determine the impact of surgery for the primary tumor in breast cancer patients with BM and to develop prognostic nomograms to predict the overall survival (OS) of breast cancer patients with BM.
18p vianrose2711 27-04-2021 9 2 Download
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The approach to palliative treatment of malignant pleural effusion (MPE) should be individualized because these patients generally have poor survival. Our study aimed to develop a model to identify prognostic factors or survival time in patients diagnosed with MPE.
7p vimontana2711 05-04-2021 14 1 Download
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This study is conducted to answer the question of whether the presence of FDI enterprises affects the survival of domestic firms or not. The authors apply the logistic regression model to analyze this crowding out effect, using the case of the textile and garment processing industry, which has a key role in Vietnamese manufacturing, industry and which also has attracted a large amount of FDI in recent years.
10p larachdumlanat129 14-01-2021 26 1 Download
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Microarray technology can acquire information about thousands of genes simultaneously. We analyzed published breast cancer microarray databases to predict five-year recurrence and compared the performance of three data mining algorithms of artificial neural networks (ANN), decision trees (DT) and logistic regression (LR) and two composite models of DT-ANN and DT-LR.
11p viwyoming2711 16-12-2020 20 1 Download
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The role of pERK, pAKT and p53 as biomarkers in patients with advanced pancreatic cancer has not yet been defined. Methods: Within the phase III study AIO-PK0104 281 patients with advanced pancreatic cancer received an erlotinib-based 1st-line regimen. Archival tissue from 153 patients was available for central immunohistochemistry staining for pERK, pAKT and p53.
10p vilisa271 22-09-2020 8 1 Download
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Preclinical evidence suggests that aspirin may inhibit lung cancer progression. In a large cohort of lung cancer patients, we investigated whether low-dose aspirin use was associated with a reduction in the risk of lung cancer-specific mortality.
10p vimoscow2711 29-08-2020 6 0 Download
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Disparities in cancer survival by socioeconomic status have been reported previously in Australia. We investigated whether those disparities have changed over time. While recent health and social policies in NSW have accompanied an increase in cancer survival overall, they have not been associated with a reduction in socioeconomic inequalities.
9p vinaypyidaw2711 26-08-2020 9 2 Download
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Prognosis is poor for patients with malignant progression such as distant metastasis of oral squamous cell carcinoma (OSCC). Evidence indicates that miR-448 promotes the proliferation and inhibits apoptosis of OSCC cells. Therefore, we aimed to investigate the function of miR-448 to predict tumor progression and prognosis of OSCC.
6p vimale2711 21-08-2020 11 2 Download
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There is already evidence that the faecal immunochemical test (FIT) is a useful tool for the diagnosis of colorectal cancer (CRC) that helps to identify symptomatic patients requiring early colonoscopy.
11p vidhaka2711 31-07-2020 9 1 Download