Synthesis and anticancer

Aim of the thesis: Synthesis of several derivatives and tubulysin analogues with the replacement of the amino acid methylpipecolic (Mep) at the N-terminal, replacing N,O-acetyl group by methyl group, and researching the role of tubuphenylalanine (Tup) group at the C-terminal.

26p extraenglish 24-05-2021 18 4   Download

Objective: Study on synthesis of nano dendrimer PAMAM with anticancer drugs carboplatin (CAR) and oxaliplatin (OXA) to reduce the toxicity of the drug to normal cells and improve the effectiveness on cancer cell destruction by increasing solubility, increasing drug storage capacity, targeting drugs passively.

27p extraenglish 24-05-2021 19 4   Download

Synthesis of several derivatives and tubulysin analogues with the replacement of the amino acid methylpipecolic (Mep) at the N-terminal, replacing N,O-acetyl group by methyl group, and researching the role of tubuphenylalanine (Tup) group at the C-terminal .

26p capheviahe27 23-02-2021 19 5   Download

Obtained by the interaction of 2-amino-3,3-dichloroacrylonitrile and chlorosulphonyl isocyanate (Z)-(5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfamoyl chloride reacts easily with excess of the aliphatic amine to form new (Z)-N-(5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)-N'-substituted sulfonamides.

12p tocectocec 25-05-2020 10 1   Download