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Synthesis of compound
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Ten new chromone derivatives were synthesized from the original 2-4-6- trihydroxyacetophenone using microwave irradiation. The product's structures were confirmed by FT-IR, 1H-NMR, and 13C-NMR spectra data. The anti-microbial activities of the obtained compounds were tested by the disc diffusion method. The results showed that most chromones have significant biological activities against Candida albicans.
10p
viambani
18-06-2024
1
0
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In this paper, we present the synthesis of intermediate compounds 2 and 3, which are the key compounds for synthesizing the derivatives of schweinfurthin G using chiral ionic liquid. These compounds are the key blocks to further synthesize schweinfurthin G derivatives for biological activity tests.
8p
viamancio
04-06-2024
2
0
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This book focuses on different techniques of asymmetric synthesis of important compounds, such as drugs and natural products. It gives insightful information on recent asymmetric synthesis by Inorganic, Organic and Enzymatic combinations. It also emphasizes chiral compounds and design of new catalyst for synthesis of compounds.
509p
vimeyers
29-05-2024
5
2
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The wave function regards like localized orbital locator, electron localized function, average localized ionization energy and non-covalent interaction are also examined as a means of theoretical evidence of the titled compound. The NBO calculations probe the intermolecular and intramolecular movement of charges, and additionally the molecule's stability. The ADMET properties are also considered for the compound with the assistance of Swiss ADMET online tool.
17p
dianmotminh02
03-05-2024
1
1
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The efficient synthesis of 12-substituted-3,4,4a,5,12,12a-hexahydrobenzo[b]acridine-1,6,11(2H)-triones starting from 2-amino-1,4-naphthoquinone, 1,3-cyclohexanedione, and different (hetero)aromatic aldehydes was developed. These reactions were carried out in acetic acid under microwave irradiation in the presence of p-toluenesulfonic acid as catalyst. The structure of the newly synthesized compounds were confirmed employing spectroscopic data as well as elemental analysis. The plausible mechanism of these three-component domino reactions was also described.
7p
dianmotminh02
03-05-2024
4
1
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The outcomes are to be compared with typical drugs given that compounds are examined against gram-positive and gram-negative strains of bacteria and fungus. Against bacterial strains, products with nitro, methyl, and bromo substituents in the p-position of the benzene ring, as well as products with the nitro group at the m-position, showed very excellent activities against bacterial strains, while compounds with chloro substituent at p-position and m-position demonstrated good activity against the fungal strains Aspergillus niger and Fusarium javanicum.
8p
dianmotminh02
03-05-2024
2
1
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As a new work searching potential bioactive hybrid derivatives for drug design, where 3-aryl-2-mercaptoquinazolin-4(3H)-one scaffold is incorporated in specific coumarin moiety with or without bearing acetamide group, the synthesis and structure of new hybrid compounds were reported.
6p
dianmotminh02
03-05-2024
2
1
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Cancer is the most destructive and fatal disease, representing an urgent medical challenge to the world. The discovery of a new anticancer candidate may help reduce or eliminate this alarming disease to a greater extent. On similar lines, in silico research was carried out on novel naphthylidene isoxazolidinedione derivatives that were logically conceived, synthesized, purified, and structurally characterized. In vitro biological evaluation revealed the most active compound 4d with an inhibitory concentration of 42.87 μM against K562 and 47.42 μM on A549 cells.
10p
dianmotminh02
03-05-2024
4
1
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In recent times many research activities have been carried out to prove the metal ion detection ability of Schiff bases. [13,14] In the present study, a new Schiff base has been synthesized from 5-bromo-2- hydroxybenzaldehyde and naphthalene-1,8-diamine and it is complexated with Co(II), Ni(II), Cu(II) and Zn(II) ions. The biological application of all the compounds has been analyzed and metal ions recognition property of the Schiff base has also been studied.
16p
dianmotminh02
03-05-2024
5
1
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This compound converted to Mannich base which interne illustrated as tridentate ligand of NO2-type. Meanwhile, the organic synthesis of the compounds is not an easy task, especially lactonization; hint naphthafuran-2-one has never been prepared from amino nitrile previously. Selected metal ions of known anticancer activity interacted with the ligand to present novel complexes to figure out the cytotoxicity effect of both organic and inorganic parts against cancer cell line.
10p
dianmotminh02
03-05-2024
2
1
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. In vitro biological evaluation revealed the most active compound 4d with an inhibitory concentration of 42.87 μM against K562 and 47.42 μM on A549 cells. The anticancer activity of this naphthylidene isoxazolidinedione derivative was evident by cell cycle and apoptosis assays, which showed arrest of the G2/M phase (65.6%) of the K562 cells and induction of apoptosis with 21.47% apoptotic cells as compared to 0.2% of untreated cells, respectively.
10p
dianmotminh02
03-05-2024
2
2
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To prepare the efficiently flame retardants (FR) for the highly flammable polymers, the novel nitrogen-phosphorus based FRs (P-N FR) (PN-3, PN-4, PN-5, and PN-6) were prepared via phosphorus halides and amine derivatives with 40- 90 % in yields. The appearance of P-N FRs are lightly white solid. All P-N FRs are water-insoluble and show a melting point above 40oC. The success of the synthesis was confirmed by NMR analysis.
8p
dianmotminh02
03-05-2024
2
2
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Ebook "Flow chemistry for the synthesis of heterocycles" provides an overview of recent developments and scope in the use of flow chemistry in relevance to heterocyclic synthesis. The heterocyclic ring is the most prominent structural motif in the vast majority of natural products as well as pharmaceutical compounds since this facilitates tuneable interactions with the biological target besides conferring a degree of structural and metabolic stability.
400p
tracanhphuonghoa1007
22-04-2024
6
3
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In addition, this γ-lactam heterocyclic ring also exists in synthetic medicinal compounds. In this manuscript, multi-component reactions (MCRs) were applied to synthesize three 1,5- disubstituted-4-ethoxycarbonyl-3-hydroxy-3-pyrroline-2-ones containing nitro group from aromatic aldehydes, 4-nitroaniline and sodium diethyl oxalacetate in absolute ethanol.
6p
viohoyo
25-04-2024
9
2
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Ebook "Synthesis of heterocycles in contemporary medicinal chemistry" is special in several aspects. First, it was composed by industrial medicinal and process chemists with decades of industrial experience. Secondly, it is dedicated to the heterocyclic drug compounds that have particularly marked the area of medicinal chemistry over the last decade.
281p
tracanhphuonghoa1007
22-04-2024
7
3
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Ebook "An integrated approach for added-value products from lignocellulosic biorefineries: Vanillin, syringaldehyde, polyphenols and polyurethane" offers the state of the art on the progress and accomplishments of 25 years of research at the Associate Laboratory LSRE-LCM - Laboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials on lignin conversion to value-added products and their downstream separation.
173p
tracanhphuonghoa1007
22-04-2024
5
2
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Ebook "Chalcogenide materials for energy conversion: Pathways to oxygen and hydrogen reactions" addresses electrocatalysis based on chalcogenides, particularly in the nanoscale domain. Special attention is paid to the hydrogen evolution reaction (HER) and the oxygen reduction reaction (ORR). The book provides an introduction to materials synthesis; the basic principles of electrocatalysis; related precious metal versus non-precious metal catalytic center chalcogenides as well as supports; and the role of such supports in stabilizing the catalytic centers.
234p
tracanhphuonghoa1007
22-04-2024
7
3
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Ebook "Synthesis of saturated oxygenated heterocycles II: 7- to 16-membered rings" presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field.
168p
tracanhphuonghoa1007
22-04-2024
4
3
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Ebook "On-surface synthesis: Proceedings of the International Workshop On-surface synthesis, École des Houches, Les Houches 25–30 May 2014" is aimed at students and researchers interested in nanochemistry and molecular devices and it gives the reader a pedagogical up-to-date vision of the most recent developments. The editor ensures a multidisciplinary approach involving molecular chemistry, surface sciences, surface spectroscopies, theory, scanning tunneling and non-contact atomic force microscopies.
287p
tracanhphuonghoa1007
22-04-2024
4
4
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Ebook "Progress in enantioselective Cu(I)-catalyzed formation of stereogenic centers" is not intended to provide a comprehensive review of all copper-catalysed reactions, but focuses on the most recent scientific advances in copper(I)-catalysed asymmetric synthesis. For this purpose, I have selected seven topics, most of which cover research conducted during the period 2010–2015. Several chapters deal with copper(I)-catalysed addition of organometallics to allylic substrates, β,β-disubstituted Michael acceptors and carbonyl groups.
229p
tracanhphuonghoa1007
22-04-2024
4
3
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