Synthetic antibacterials

Ebook "Antibacterials (Volume I)" covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level,...

203p tracanhphuonghoa1007 22-04-2024 3 2   Download

Amongst soft chemical synthetic routes, the ionothermal synthesis method (using an ionic liquid) has attracted research tremendously due to their remarkable features especially in the case of TiO2 nanoparticles synthesis.

7p viberbers 09-08-2023 4 3   Download

The Maillard reaction products (MRPs) were synthesized during the gamma irradiation of mixtures of chitosan (CT) and/or oligochitosan (OC) with glucosamine (GA) at the dose of 25 kGy and investigated their some characteristics. The formations of MRPs were determined by UV-vis spectromectric analyses at the wavelength of 284 nm and 420 nm.

8p vicedric 08-02-2023 6 4   Download

Lactoferricin (Lfcin) is an antimicrobial activity center of lactoferrin, produced by hydrolysis from the N-terminal of lactoferrin. It was hypothesized that the intramolecular disulfide bond in Lfcin could affect its antibacterial function through influencing its molecular structure.

10p vigandhi 23-02-2022 10 1   Download

Isatin, 1H -indoline-2,3-dione, an endogenous compound, is also a synthetically versatile molecule that possesses a diversity of biological activities including anticonvulsant, antibacterial, antifungal, antiviral, anticancer, and cytotoxic properties. Based on the promising cytotoxic activity studies on N -substituted isatin derivatives, a series of 18 derivatives of 2-(2,3-dioxo-2,3-dihydro-1H -indol-1-yl)-N -phenylacetamide were designed, synthesized, and characterized according to their analytical and spectral data.

9p langthannam 29-12-2021 12 1   Download

Moxifloxacin (MOX) is a fourth-generation synthetic fluoroquinolone antibacterial agent with many important therapeutic properties. Fluorescence quenching was used to study the interaction of MOX with calf thymus DNA (ctDNA) in aqueous solution. As the most common genetic material of various biosomes in nature, deoxyribonucleic acid (DNA) plays a key role in different kinds of vital processes including gene expression, mutagenesis, cell death, etc.

8p langthannam 29-12-2021 8 0   Download

The present study aimed to explore the antibacterial activity of some seaweed extracts against urinary tract (UTI) infectious bacteria. To compare the activity of these extracts as natural drug sources with the standard synthetic antibiotics against multidrug resistant (MDR) isolates. Finally, to compare the virulence gene profiles of the UTI isolates and detect the effect of seaweeds treatment on their virulence activities.

18p nguaconbaynhay10 22-01-2021 10 2   Download

Nanotechnology has recently emerged as an elementary discipline of science that explores the interaction of synthetic and biological materials. Nanotechnology is currently employed as a tool to exploit the darkest avenues of medical sciences to combat dreadful diseases caused by drug resistant microbes. Silver nanoparticles (Ag NPs) have been well known for its inhibitory and bactericidal effects. Silver Nanoparticles was synthesized by ecofriendly biogenic approach mediated by using the culture supernatant of Bacillus sp. DRI-6.

8p kethamoi6 29-06-2020 13 1   Download

Many plants in Africa are medicinal. The use of medicinal natural plants predates the establishment of antibiotics and other modern drugs into the African continent. The antibacterial activity of Gongronema latifolium and a synthetic antibiotic (Rocephin) on a clinical isolate of Staphylococcus aureus was evaluated in vivo using albino Wister rats. Five (5) adult female rats with weight ranging from 120 – 180 kg were purchased, housed, fed and nurtured for five days. Four (4) of the rats were inoculated with 0.1 ml 4hour growing broth culture of Staphylococcus aureus.

8p nguaconbaynhay6 23-06-2020 8 1   Download

Synthetic antioxidants and antimicrobials are losing ground to their natural counterparts and therefore, the food industry has motivated to seek other natural alternatives. Apple pomace, a by-product in the processing of apples, is rich in polyphenols, and plant polyphenols have been used as food additives owing to their strong antioxidant and antimicrobial properties.

9p vijiraiya2711 27-05-2020 12 1   Download

Milk protein fibre is made out of skimmed milk. Main components of this fibre are casein proteins, drawn from the cow’s milk. It is responsible for the white, opaque appearance of milk in which it is combined with calcium and phosphorus as clusters of casein molecules, called micelles. This fiber contains eighteen types of amino-acids extracts that helps in the nourishments of the skin and makes it healthier. Milk protein fibre is a blend of nature, science and technology that has benefits of natural as well as synthetic fibre.

8p nguathienthan4 18-04-2020 22 1   Download

Bacterial multidrug resistance (MDR) constitutes a major hurdle in the treatment of infectious diseases worldwide. The present study was designed to evaluate the antibacterial activities of synthetic p-toluenesulfonyl-hydrazinothiazoles against multidrug resistant Gram-negative bacteria.

7p vienzym2711 30-03-2020 8 2   Download

In this study, silver nanoparticles (AgNPs) using leaf extracts of Azadirachta indica were synthesized and its antibacterial activity was investigated. The synthesis of AgNPs was done by using the green synthetic method and analyzed by UV-Visible spectroscopy, Fourier transform infrared spectroscopy and transmission electron microscopy. The antibacterial activity of AI AgNPs was studied by agar well diffusion method.

7p cothumenhmong4 23-03-2020 13 1   Download

Screening of antimicrobial compound from waste and low cost plant material would be better alternative material for synthetic food preservatives. Hence, in the present study, beetroot peel and whole radish was chosen. Beet root peel extract (BPE) and Whole radish extract (WRE) was prepared using water and screened for the antibacterial compound against various food borne pathogen using modified well diffusion assay. Then the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) level was identified for the various food pathogens.

10p nguaconbaynhay3 07-02-2020 30 0   Download

Plant extracts continues the numerous searches for more effective drugs of plant origin which are less toxic and available for low socio-economic population in the treatment of diseases caused by pathogenic bacteria. The potential for developing antibacterial from higher plants appears rewarding as it will result to the development of a phytomedicine to act against microbes. Plant based antibacterials have enormous therapeutic potentials as they can serve the purpose with lesser side effects that are often associated with synthetic antibacterials.

5p kethamoi2 15-12-2019 22 1   Download

Schiff bases are aldehyde- or ketone-like compounds in which the carbonyl group is replaced by an imine or azomethine group. They are widely used for industrial purposes and also exhibit a broad range of biological activities. This short review compiles examples of the most promising antimalarial, antibacterial, antifungal, and antiviral Schiff bases. An overview of synthetic methodologies used for the preparation of Schiff bases is also described.

8p kethamoi1 20-11-2019 10 0   Download

This study describes the antibacterial activity of ginger (G), mangoginger (M) and turmeric (T) and mixtures thereof i.e. ginger and mangoginger (GM), ginger and turmeric (GT), turmeric and mangoginger (TM), and a mixture of peels (P) and 4 synthetic compounds (HC-1, HC-2, HC-3 and HC-4).

15p vitamix 15-02-2019 27 1   Download

(bq) part 2 book “kucers’ the use of antibiotics” has contents: antifolate agents and other synthetic antibacterials, quinolones and fluoroquinolones, nitroimidazoles, anti-tuberculous drugs, polyenes, echinocandins, allylamines and benzylamine derivatives,… and other contents.

2979p tieu_vu15 07-09-2018 24 1   Download

Whereas significant knowledge is accumulating on the antibacterial and antifungal properties of host defense peptides (HDPs) and their synthetic mimics, much less is known of their activities against parasites. A variety ofin vitro andin vivo antiparasitic assays suggest that these notorious anti-microbial compounds could represent a powerful tool for the development of novel drugs to fight parasites in the vertebrate host or to complement current therapeutic strategies

9p viettel02 20-02-2013 38 2   Download

For the last 60 or so years the chemotherapy of bacterial infections has been dominated by natural products and their semi-synthetic variants. Although the term antibiotic was initially used exclusively to describe those anti-bacterials of natural or semi-synthetic origin, it has become broadened in common usage to include antibacterial agents of purely synthetic origin as well. The emphasis of this chapter will be on the discovery of novel prototype structures that represent the different classes of antibiotic e.g.

0p thienbinh1311 13-12-2012 46 6   Download