Systemic therapies

Part 1 book "Neural stem cells and cellular therapy" includes content: Introduction adult neural stem cells - the promise of the future, neurogenesis in the adult central nervous system, BrdU immunohistochemistry for studying adult neurogenesis - paradigms, pitfalls, limitations and validation; adult neural stem cells, neurogenic niches and cellular therapy;... and other contents.

124p dianmotminh04 12-07-2024 0 0   Download

Prostate cancer is dependent on androgen receptor (AR) signaling, and androgen deprivation therapy (ADT) has proven effective in targeting prostate cancer. However, castration-resistant prostate cancer (CRPC) eventually emerges. AR signaling inhibitors (ARSI) have been also used, but resistance to these agents develops due to genetic AR alterations and epigenetic dysregulation.

12p vishanshan 27-06-2024 1 1   Download

For patients with locally advanced rectal cancer (LARC), total neoadjuvant therapy (TNT), namely, intensifying preoperative treatment through the integration of radiotherapy and systemic chemotherapy before surgery, was commonly recommended as the standard treatment.

10p vishanshan 27-06-2024 1 1   Download

Panel gene sequencing is an established diagnostic tool for precision oncology of solid tumors, but its utility for the treatment of cancers of the digestive system in clinical routine is less well documented.

10p vishanshan 27-06-2024 1 1   Download

Macroscopic vascular invasion (MVI) significantly impacts survival in patients with hepatocellular carcinoma (HCC), warranting systemic therapy over locoregional therapy. Despite novel approaches, HCC with MVI has a poor prognosis compared to early-to intermediate-stage HCC. This study aimed to evaluate the safety and efficacy of carbon-ion radiotherapy (C-ion RT) for HCC characterized by MVI.

9p vishanshan 27-06-2024 2 1   Download

Nervous system toxicity (NST) is one of the most frequent and dangerous side effects of chimeric antigen receptor T-cell (CAR-T) therapy, which is an effective treatment for related tumors in most relapsed/refractory (r/r) hematologic malignancies. Current clinical trial data do not fully reflect the real-world situation. Therefore, this study evaluated the NST of CAR-T therapy using the FDA Adverse Event Reporting System (FAERS).

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The present research was designated to investigate the potential of ZnONP nanocomposites as a cancer chemotherapeutic-based drug delivery system and to assess the anti-tumor and anti-inflammatory effectiveness of ZnONP nanocomposites combination with systemic chemotherapeutic drugs doxorubicin (DOX) and folic acid (FA) in Ehrlich ascites carcinoma (EAC) tumor cell line both in vitro and in vivo.

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A new class of antibody-based drug therapy with the potential for disease modification is now available for Alzheimer’s disease (AD). However, the complexity of drug eligibility, administration, cost, and safety of such disease modifying therapies (DMTs) necessitates adopting new treatment and care pathways.

12p vishanshan 27-06-2024 2 1   Download

Diffuse midline glioma (DMG), H3 K27M-mutant is a type of diffuse high-grade glioma that occurs in the brain midline carrying an extremely poor prognosis under the best efforts of surgery, radiation, and other therapies. For better therapy, we explored the efficacy and toxicity of a novel therapy that combines apatinib and temozolomide in DMG.

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The prognosis of patients with Relapsed/Refractory Osteosarcoma (R/R OS) remains dismal without an agreement on systemic therapy. The use of High-Dose Ifosfamide (14 g/sqm) with an external pump in outpatient setting (14-IFO) in R/R OS patients is limited. This study represents the first retrospective cohort analysis focused on evaluating the activity and toxicity of 14-IFO in this setting.

12p vikoch 27-06-2024 1 1   Download

Invasive breast cancer (IBC) is a leading cause of cancer-related death among women in Israel, regardless of ethnicity. This study compared IBC epidemiological, clinical, and pathological characteristics in Bedouin and Jewish patients in southern Israel.

8p vikoch 27-06-2024 1 1   Download

Primary tumor removal by cytoreductive nephrectomy in synchronous metastatic renal cell carcinoma patients has been investigated in the context of various treatment regimens. Two randomized controlled trials investigated the role and timing of cytoreductive nephrectomy in the era of targeted therapy and demonstrated that upfront nephrectomy should no longer be performed when patients require systemic therapy.

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The current standard of care in the neoadjuvant setting for high-risk HER2-positive (HER2+) breast cancer is to combine systemic chemotherapy with dual HER2 blockade, trastuzumab and pertuzumab. Targeted therapies have significantly improved outcomes for patients with HER2-positive breast cancer.

8p vikoch 27-06-2024 1 1   Download

Part 2 book "Small animal cardiovascular medicine" includes content: Feline unclassified and restrictive cardiomyopathy; heartworm infection and disease (dirofilariasis); infective endocarditis (and annuloaortic ectasia); pericardial disease and cardiac neoplasia; pulmonary arterial and systemic arterial hypertension; diagnosis and treatment of arrhythmias (dysrhythmias); syncope; drugs used in treatment of cardiac arrhythmias; interventional antiarrhythmic therapy; thromboembolic disease; the effects of systemic disease on the cardiovascular system.

604p dianmotminh03 17-06-2024 0 0   Download

This compassionate guide explains how hepatitis C affects the liver and the body and provides solid advice on today's treatment options-from drugs (and their side effects) to transplants and alternative therapies-as well as tips on dealing with the emotional and financial burdens the disease brings with it. Nina L Paul, PhD (New York, NY) earned her doctorate in infectious disease epidemiology and immunology from Yale University. She has researched viruses (human immunodeficiency virus and others) and the immune system.

314p zizaybay1104 29-05-2024 2 2   Download

Part 2 book "Horse Owner's veterinary handbook" includes contents: The nervous system, the digestive system, nutrition and feeding, sex and reproduction, pregnancy and foaling, pediatrics, geriatrics, drugs and medications, alternative therapies.

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Part 2 book "Essentials of nuclear medicine and molecular imaging" includes contents: Skeletal system, genitourinary system and adrenal glands, Non-PET neoplasm imaging and radionuclide therapy, hybrid PET/CT neoplasm imaging, inflammation and infection imaging, authorized user and radioisotope safety issues.

301p dianmotminh01 14-05-2024 4 0   Download

Part 1 book "Feline emergency and critical care medicine" includes contents: Approach to the critically ill cat, cardiopulmonary resuscitation (cpr), shock, trauma, anesthesia for critically ill feline patient, anesthetic protocols for systemically healthy cats, analgesia in the critically ill cat, fluid therapy, nutritional support for the critically ill feline patient, respiratory emergencies and pleural space disease, upper airway disease, lower airway disease,... and other contents.

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Ebook "The proteasome in neurodegeneration" will be of relevance for many years to come, and are intended to generate interest in the nuances of the UPS system, and highlight new avenues for the understanding of the UPS and the generation of UPS-based therapies for the treatment of neurodegenerative diseases.

314p ladongphongthanh1008 22-04-2024 5 2   Download

Ebook "Regenerative medicine and cell therapy" discusses cutting-edge science in the field of regenerative biomedicine and its therapeutic applications to various medical disorders. The chapters are written by renowned scientists in the specific fields. This will be a useful book for basic and clinical scientists, especially young investigators and stem cell biology students who are newly entering the world of stem cells research.

322p ladongphongthanh1008 22-04-2024 4 1   Download